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      "canonicalId": "NCT07897708",
      "title": "A Study to Learn How Different Amounts of the Study Medicine Called PF-08161842 Are Tolerated and Act in the Body in Healthy and Older Adults",
      "scientificTitle": "A PHASE 1, RANDOMIZED, DOUBLE-BLIND, SPONSOR-OPEN, PLACEBO CONTROLLED, DOSE ESCALATING STUDY TO EVALUATE THE SAFETY, TOLERABILITY, PHARMACOKINETICS, AND PHARMACODYNAMICS OF SINGLE AND MULTIPLE ORAL DOSES OF PF-08161842 IN HEALTHY AND OLDER PARTICIPANTS",
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          "type": "DRUG",
          "description": "Oral tablet (Parts A and B)."
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          "Number of Participants With Serious Adverse Events (SAEs)",
          "Number of Participants With Clinically Significant Laboratory Abnormalities",
          "Number of Participants With Clinically Significant Vital Signs Abnormalities",
          "Number of Participants With Clinically Significant Electrocardiogram (ECG) Findings",
          "Number of Participants With Clinically Significant Columbia-Suicidality Severity Rating Scale (C-SSRS)"
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          "Area Under the Curve From Time Zero to end of Dosing Interval (AUCtau)",
          "Maximum Observed Plasma Concentration (Cmax)",
          "Time to Reach Maximum Observed Plasma Concentration (Tmax)",
          "Area Under the Curve From Time Zero to Extrapolated Infinite Time (AUCinf) if data permit",
          "Plasma Decay Half-life (t1/2) if data permit",
          "Cerebrospinal Fluid (CSF) Concentration of PF-08161842"
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      "completionDate": "2027-12-14",
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