{ "data": { "asOf": "2026-10-30T22:25:00.171Z", "dedupMethod": "exact cross-registry identifier matching; probabilistic = review only", "byRegistry": { "clinicaltrials_gov": 1 }, "canonicalTrial": { "canonicalId": "NCT07897409", "title": "The Impact of Using Nicorandil for the Prevention of Doxorubicin-Induced Cardiotoxicity", "scientificTitle": "The Impact of Using Nicorandil for the Prevention of Doxorubicin-Induced Cardiotoxicity, Including Quality of Life and Cost Analysis Among Breast Cancer Patients at Breast Cancer Hospital: A Randomized Controlled Trial in Egypt", "status": "not_yet_recruiting", "studyType": "interventional", "phase": [ "PHASE2" ], "conditions": [ "Doxorubicin Induced Cardiotoxicity", "Doxorubicin Induced Cardiomyopathy", "Doxorubicin", "Doxorubicin Adverse Reaction" ], "interventions": [ { "name": "Nicorandil Oral Tablet", "type": "DRUG", "description": "drug" }, { "name": "Adriamycin (Doxorubicin)", "type": "DRUG", "description": "AC regimen (doxorubicin 60 mg/m2 intravenous every 21 days, cyclophosphamide 600 mg/m2 intravenous every 21 days for 4 cycles)." } ], "sponsor": { "name": "Universiti Sains Malaysia", "type": "OTHER" }, "locations": [ { "city": "Cairo", "country": "Egypt", "facility": "National Cancer Institute" } ], "outcomes": { "other": [], "primary": [ "To evaluate the effect of nicorandil on left ventricular ejection fraction in breast cancer patients receiving doxorubicin.", "To evaluate the safety of nicorandil" ], "secondary": [ "To assess patients' quality of life", "To determine the effect of nicorandil on global longitudinal strain in breast cancer patients receiving doxorubicin.", "To evaluate the cost-utility of nicorandil as a cardioprotective agent against doxorubicin-induced cardiotoxicity.", "To assess the effect of nicorandil on cardiac biomarkers" ] }, "eligibility": { "sex": "FEMALE", "criteria": "Inclusion criteria\n\n* 18 years - 65 years\n* Female patients with stage (I, II, III) breast cancer.\n* Left ventricular ejection fraction (LVEF) ≥ 55% upon breast cancer diagnosis.\n* Systolic blood pressure ≥ 90 mmHg\n* Estimated glomerular filtration rate (eGFR ≥ 60 mL/min per 1.73 m²). Exclusion criteria\n* Pregnant and lactating mothers.\n* Metastatic breast cancer. (stage IV).\n* Patients are currently using beta-blockers and phosphodiesterase 5 inhibitors.\n* Patients who require chronic use of aspirin or chronic use of corticosteroids (≥3 months).\n* Patients who are diagnosed with heart failure, myocardial infarction, stable angina, cardiogenic shock, hypovolemia, or previous coronary revascularization.\n* Previously treated with anthracyclines.\n* Previous gastrointestinal bleeding, ulcer, or perforation.\n* Severe hepatic impairment (ALT, AST ≥ 5 upper limit normal), or diagnosed with clinical evidence of hepatic ascites, encephalopathy, variceal bleeding, decompensated cirrhosis, and acute hepatitis.", "maximumAge": "65 Years", "minimumAge": "18 Years", "healthyVolunteers": false }, "enrollment": { "type": "ESTIMATED", "count": 146 }, "startDate": "2026-10-01", "completionDate": "2027-09-01", "lastUpdated": "2026-10-27T00:00:00.000Z", "firstPosted": "2026-10-27T00:00:00.000Z", "resultsAvailable": false, "sourceRegistries": [ "clinicaltrials_gov" ], "sourceUrls": [ "https://clinicaltrials.gov/study/NCT07897409" ] }, "identifiers": [ { "idType": "nct", "idValue": "NCT07897409", "declaredBy": "clinicaltrials_gov" } ], "sourceRecords": [ { "registry": "clinicaltrials_gov", "registryName": "ClinicalTrials.gov", "license": "public-domain", "sourceId": "NCT07897409", "sourceUrl": "https://clinicaltrials.gov/study/NCT07897409", "sourceStatus": "NOT_YET_RECRUITING", "retrievedAt": "2026-10-28T04:32:18.986Z", "payloadSha256": "2f6d2499953c87cefa36e65d0e6b09f8581da1f17e53813640a7006346cd88ff", "piiRedacted": true } ], "citation": { "canonicalId": "NCT07897409", "sources": [ { "registry": "clinicaltrials_gov", "registryName": "ClinicalTrials.gov", "license": "public-domain", "sourceId": "NCT07897409", "verifyAt": "https://clinicaltrials.gov/study/NCT07897409", "retrievedAt": "2026-10-28T04:32:18.986Z", "payloadSha256": "2f6d2499953c87cefa36e65d0e6b09f8581da1f17e53813640a7006346cd88ff", "text": "ClinicalTrials.gov, record NCT07897409 (https://clinicaltrials.gov/study/NCT07897409), retrieved 2026-10-28, licence: public-domain." } ], "crossRegistry": false, "dedupMethod": "exact cross-registry identifier matching; probabilistic = review only", "text": "Trial NCT07897409, registered in ClinicalTrials.gov, retrieved 2026-10-28. Verify at the source URLs listed; each retrieval is checksummed.", "note": "Only one registry is known to hold this trial. Absence from the others is not evidence it was not registered there." }, "provenanceNote": "Personal contact fields (names, emails, phone numbers, addresses) are stripped from every stored payload. No participant-level data is collected or served." }, "_meta": { "api": "The Last Economy Wire: World Trials API", "version": "1.0", "schemaVersion": "1", "correlationId": "req_OXnH9Z7WpY6G", "generatedAt": "2026-10-30T22:25:00.171Z", "documentation": "https://negativeresistance.com/embed", "license": "Free for any use. Attribution appreciated.", "degraded": false, "provenance": { "sources": [ "clinicaltrials_gov" ], "attribution": { "clinicaltrials_gov": "ClinicalTrials.gov: licence: public-domain, https://clinicaltrials.gov/data-api/api-docs" }, "dedupMethod": "exact cross-registry identifier matching; probabilistic = review only", "limitations": [], "provenanceEndpoint": "/api/v1/sources" }, "freshness": { "newestEvidenceAt": null, "lastSyncedAt": { "clinicaltrials_gov": "2026-10-28T04:33:30.663Z" }, "degradedSources": [], "worldwide": false, "maxAgeHours": 65.9, "fromCache": false }, "links": { "discovery": "https://negativeresistance.com/api/v1", "openapi": "https://negativeresistance.com/api/v1/openapi.json", "mcp": "https://negativeresistance.com/api/v1/mcp", "agentCard": "https://negativeresistance.com/.well-known/agent.json", "aiPlugin": "https://negativeresistance.com/.well-known/ai-plugin.json", "sdk": "https://negativeresistance.com/api/v1/sdk", "status": "https://negativeresistance.com/api/v1/status", "provenance": "https://negativeresistance.com/api/v1/sources", "contract": "https://negativeresistance.com/api/v1/contract", "curriculum": "https://negativeresistance.com/api/v1/curriculum", "graph": "https://negativeresistance.com/api/v1/graph", "openQuestions": "https://negativeresistance.com/api/v1/open-questions", "scoreboard": "https://negativeresistance.com/api/v1/scoreboard", "findings": "https://negativeresistance.com/api/v1/findings", "claims": "https://negativeresistance.com/api/v1/claims", "threads": "https://negativeresistance.com/api/v1/threads", "assignment": "https://negativeresistance.com/api/v1/assignment", "changes": "https://negativeresistance.com/api/v1/changes", "hello": "https://negativeresistance.com/api/v1/hello", "errors": "https://negativeresistance.com/api/v1/errors", "webhooks": "https://negativeresistance.com/api/v1/webhooks", "a2a": "https://negativeresistance.com/api/v1/a2a", "deadEnds": "https://negativeresistance.com/api/v1/dead-ends", "decompositions": "https://negativeresistance.com/api/v1/decompositions", "rungs": "https://negativeresistance.com/api/v1/rungs", "methods": "https://negativeresistance.com/api/v1/methods", "reality": "https://negativeresistance.com/api/v1/reality", "council": "https://negativeresistance.com/api/v1/council", "calibration": "https://negativeresistance.com/api/v1/calibration", "freshness": "https://negativeresistance.com/api/v1/freshness", "mission": "https://negativeresistance.com/api/v1/mission", "twin": "https://negativeresistance.com/api/v1/twin", "twinExperiment": "https://negativeresistance.com/api/v1/twin/experiment", "betaCell": "https://negativeresistance.com/api/v1/twin/beta-cell", "patientModel": "https://negativeresistance.com/api/v1/twin/patient-model", "agentCardCanonical": "https://negativeresistance.com/.well-known/agent-card.json", "collaborate": "https://negativeresistance.com/collaborate", "manifesto": "https://negativeresistance.com/about", "documentation": "https://negativeresistance.com/embed", "connect": "https://negativeresistance.com/connect", "llmsTxt": "https://negativeresistance.com/llms.txt", "llmsFullTxt": "https://negativeresistance.com/llms-full.txt" }, "disclaimer": "Research data from public registries and literature; not medical advice." } }