{ "data": { "asOf": "2026-10-30T22:26:14.603Z", "dedupMethod": "exact cross-registry identifier matching; probabilistic = review only", "byRegistry": { "clinicaltrials_gov": 1 }, "canonicalTrial": { "canonicalId": "NCT07897383", "title": "Investigating the Effects of 24 Hour LEAP2 Infusion in Individuals With Overweight and Obesity", "scientificTitle": "Investigating the Effects of 24 Hour Ghrelin Receptor Antagonism in Individuals With Overweight and Obesity", "status": "not_yet_recruiting", "studyType": "interventional", "phase": [ "PHASE1", "PHASE2" ], "conditions": [ "Obesity & Overweight" ], "interventions": [ { "name": "Liver-expressed antimicrobial peptide 2", "type": "BIOLOGICAL", "description": "Continuous intravenous infusion of LEAP2 (Liver-Expressed Antimicrobial Peptide 2), an endogenous inverse agonist and competitive antagonist of the ghrelin receptor (GHSR), administered at 40 pmol/kg/min for 24 hours. 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The placebo enables assessment of the physiological effects of ghrelin receptor blockade by LEAP2 in individuals with overweight or obesity." } ], "sponsor": { "name": "University Hospital, Gentofte, Copenhagen", "type": "OTHER" }, "locations": [], "outcomes": { "other": [ "Growth hormone", "LH (luteinizing hormone)", "Acyl-ghrelin", "Nausea", "LEAP2, insulin, glucagon and other appetite/glucose-related hormones", "Lipids and metabolic biomarkers", "Energy expenditure", "Duration of ad libitum meals", "Water intake during ad libitum meals", "Urinary nitrogen excretion", "Other metabolic, endocrine and inflammatory biomarkers", "Subcutaneous adipose tissue profiling", "Systolic blood pressure", "Organ markers", "Continuous glucose monitoring (CGM) glucose metrics", "Continuous glucose monitoring (CGM) glucose metrics", "Continuous glucose monitoring (CGM) glucose metrics", "Continuous glucose monitoring (CGM) glucose metrics", "Continuous glucose monitoring (CGM) glucose metrics", "Continuous glucose monitoring (CGM) glucose metrics", "Continuous glucose monitoring (CGM) glucose metrics", "Continuous glucose monitoring (CGM) glucose metrics", "Continuous glucose monitoring (CGM) glucose metrics", "Continuous glucose monitoring (CGM) glucose metrics", "FSH (follicle-stimulating hormone)", "Insulin-like growth factor 1 (IGF-1)", "Comfort", "Thirst", "Hunger", "Fullness", "Prospective food intake", "Diastolic blood pressure", "Heart rate", "Satiety", "Respiratory Exchange Ratio (RER)" ], "primary": [ "Food intake" ], "secondary": [ "Total food intake/24 hours", "Total food intake/24 hours", "Food intake lunch", "Food intake dinner", "Food intake breakfast", "Composite score of sensation of hunger", "Explicit liking (Leeds Food Preference Questionnaire)", "Postprandial plasma concentrations of glucose after liquid meal test", "Snack intake", "Energy intake at lunch relative to body weight", "Gastric emptying", "Energy intake at dinner relative to body weight", "Energy intake at breakfast relative to body weight", "Snack energy intake relative to body weight", "Explicit wanting (Leeds Food Preference Questionnaire)", "Snack buffet food preference", "Implicit wanting (Leeds Food Preference Questionnaire)", "Gastric emptying", "Gastric emptying" ] }, "eligibility": { "sex": "ALL", "criteria": "Inclusion Criteria:\n\n* Age between 18 and 65 years old\n* Body mass index (BMI) ≥ 25 kg/m2\n* Body fat mass ≥ 20% for male individuals and ≥ 30% for female individuals\n* Informed oral and written consent\n\nExclusion Criteria:\n\n* Anemia\n* Plasma alanine aminotransferase (ALT) \\> 2 times normal value\n* History of hepatobiliary and/or gastrointestinal disorder\n* eGFR \\< 60\n* Regular tobacco smoking and/or use of other nicotine products\n* Type 1 or type 2 diabetes medical treatment\n* Women of childbearing potential who are not using effective contraception\n* Pregnancy or breastfeeding\n* Any ongoing medication or medical condition that investigators evaluate would interfere with study participation.", "maximumAge": "65 Years", "minimumAge": "18 Years", "healthyVolunteers": false }, "enrollment": { "type": "ESTIMATED", "count": 18 }, "startDate": "2026-11-30", "completionDate": "2027-08-01", "lastUpdated": "2026-10-27T00:00:00.000Z", "firstPosted": "2026-10-27T00:00:00.000Z", "resultsAvailable": false, "sourceRegistries": [ "clinicaltrials_gov" ], "sourceUrls": [ "https://clinicaltrials.gov/study/NCT07897383" ] }, "identifiers": [ { "idType": "nct", "idValue": "NCT07897383", "declaredBy": "clinicaltrials_gov" } ], "sourceRecords": [ { "registry": "clinicaltrials_gov", "registryName": "ClinicalTrials.gov", "license": "public-domain", "sourceId": "NCT07897383", "sourceUrl": "https://clinicaltrials.gov/study/NCT07897383", "sourceStatus": "NOT_YET_RECRUITING", "retrievedAt": "2026-10-28T04:32:38.871Z", "payloadSha256": "aabebd955d809ef4c15e39b82e73dc77689e0fb06c99ea5188540f88919a84d2", "piiRedacted": true } ], "citation": { "canonicalId": "NCT07897383", "sources": [ { "registry": "clinicaltrials_gov", "registryName": "ClinicalTrials.gov", "license": "public-domain", "sourceId": "NCT07897383", "verifyAt": "https://clinicaltrials.gov/study/NCT07897383", "retrievedAt": "2026-10-28T04:32:38.871Z", "payloadSha256": "aabebd955d809ef4c15e39b82e73dc77689e0fb06c99ea5188540f88919a84d2", "text": "ClinicalTrials.gov, record NCT07897383 (https://clinicaltrials.gov/study/NCT07897383), retrieved 2026-10-28, licence: public-domain." } ], "crossRegistry": false, "dedupMethod": "exact cross-registry identifier matching; probabilistic = review only", "text": "Trial NCT07897383, registered in ClinicalTrials.gov, retrieved 2026-10-28. 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