{ "data": { "asOf": "2026-10-30T22:27:01.206Z", "dedupMethod": "exact cross-registry identifier matching; probabilistic = review only", "byRegistry": { "clinicaltrials_gov": 1 }, "canonicalTrial": { "canonicalId": "NCT07893821", "title": "Renal Denervation in Patients With Atrial Fibrillation and Hypertension", "scientificTitle": "A Pilot Study Evaluating Renal Denervation in Heart Failure Patients: A Two-Phase Prospective Study - Phase 1", "status": "recruiting", "studyType": "interventional", "phase": [], "conditions": [ "Atrial Fibrillation (Paroxysmal)", "Hypertension", "Heart Failure With Preserved Ejection Fraction (HFPEF)" ], "interventions": [ { "name": "Catheter-based renal artery electrical stimulation (as a feasibility assessment for renal denervation)", "type": "PROCEDURE", "description": "During a scheduled EP study ± VT/PVC ablation:\n\nRenal arteries are selectively visualized with angiography. The ablation catheter is advanced into each renal artery. Electrical stimulation is delivered: 10 V, 0.4 ms pulse width, 100 ms cycle length, 30 seconds per renal artery Blood pressure response is measured through arterial monitoring. A positive response is defined as ≥10 mmHg increase in systolic blood pressure." } ], "sponsor": { "name": "Pavel Antiperovitch", "type": "OTHER" }, "locations": [ { "city": "London", "country": "Canada", "facility": "London Heart Rhythm Program" } ], "outcomes": { "other": [], "primary": [ "Technical Success Rate of Renal Artery Cannulationn", "Successful Delivery of Electrical Stimulation", "Change in Invasive Arterial Blood Pressure During Renal Artery Stimulation" ], "secondary": [] }, "eligibility": { "sex": "ALL", "criteria": "Inclusion Criteria:\n\n1. Age ≥18 years\n2. Scheduled for EP study +/- catheter ablation\n3. Adequate renal function (eGFR ≥45 mL/min/1.73m²)\n\nExclusion Criteria:\n\n1. Hemodynamic instability\n2. Renal artery stenosis \\>50%\n3. Single functioning kidney\n4. Previous renal artery intervention\n5. Pregnancy or nursing\n6. Life expectancy \\<12 months\n7. Unwilling or unable to provide informed consent\n8. Participation in a clinical trial that may impact the outcomes of the current study", "minimumAge": "18 Years", "healthyVolunteers": false }, "enrollment": { "type": "ESTIMATED", "count": 10 }, "startDate": "2026-08-01", "completionDate": "2029-08-01", "lastUpdated": "2026-10-26T00:00:00.000Z", "firstPosted": "2026-10-26T00:00:00.000Z", "resultsAvailable": false, "sourceRegistries": [ "clinicaltrials_gov" ], "sourceUrls": [ "https://clinicaltrials.gov/study/NCT07893821" ] }, "identifiers": [ { "idType": "nct", "idValue": "NCT07893821", "declaredBy": "clinicaltrials_gov" } ], "sourceRecords": [ { "registry": "clinicaltrials_gov", "registryName": "ClinicalTrials.gov", "license": "public-domain", "sourceId": "NCT07893821", "sourceUrl": "https://clinicaltrials.gov/study/NCT07893821", "sourceStatus": "RECRUITING", "retrievedAt": "2026-10-28T04:32:12.787Z", "payloadSha256": "fa19e3f611ad82a8c20ee2aed3f733b6e5402f58af7eb8d99d42883566468ff7", "piiRedacted": true } ], "citation": { "canonicalId": "NCT07893821", "sources": [ { "registry": "clinicaltrials_gov", "registryName": "ClinicalTrials.gov", "license": "public-domain", "sourceId": "NCT07893821", "verifyAt": "https://clinicaltrials.gov/study/NCT07893821", "retrievedAt": "2026-10-28T04:32:12.787Z", "payloadSha256": "fa19e3f611ad82a8c20ee2aed3f733b6e5402f58af7eb8d99d42883566468ff7", "text": "ClinicalTrials.gov, record NCT07893821 (https://clinicaltrials.gov/study/NCT07893821), retrieved 2026-10-28, licence: public-domain." } ], "crossRegistry": false, "dedupMethod": "exact cross-registry identifier matching; probabilistic = review only", "text": "Trial NCT07893821, registered in ClinicalTrials.gov, retrieved 2026-10-28. Verify at the source URLs listed; each retrieval is checksummed.", "note": "Only one registry is known to hold this trial. Absence from the others is not evidence it was not registered there." }, "provenanceNote": "Personal contact fields (names, emails, phone numbers, addresses) are stripped from every stored payload. No participant-level data is collected or served." }, "_meta": { "api": "The Last Economy Wire: World Trials API", "version": "1.0", "schemaVersion": "1", "correlationId": "req_CSTMq6C58p08", "generatedAt": "2026-10-30T22:27:01.206Z", "documentation": "https://negativeresistance.com/embed", "license": "Free for any use. Attribution appreciated.", "degraded": false, "provenance": { "sources": [ "clinicaltrials_gov" ], "attribution": { "clinicaltrials_gov": "ClinicalTrials.gov: licence: public-domain, https://clinicaltrials.gov/data-api/api-docs" }, "dedupMethod": "exact cross-registry identifier matching; probabilistic = review only", "limitations": [], "provenanceEndpoint": "/api/v1/sources" }, "freshness": { "newestEvidenceAt": null, "lastSyncedAt": { "clinicaltrials_gov": "2026-10-28T04:33:30.663Z" }, "degradedSources": [], "worldwide": false, "maxAgeHours": 65.9, "fromCache": false }, "links": { "discovery": "https://negativeresistance.com/api/v1", "openapi": "https://negativeresistance.com/api/v1/openapi.json", "mcp": "https://negativeresistance.com/api/v1/mcp", "agentCard": "https://negativeresistance.com/.well-known/agent.json", "aiPlugin": "https://negativeresistance.com/.well-known/ai-plugin.json", "sdk": "https://negativeresistance.com/api/v1/sdk", "status": "https://negativeresistance.com/api/v1/status", "provenance": "https://negativeresistance.com/api/v1/sources", "contract": "https://negativeresistance.com/api/v1/contract", "curriculum": "https://negativeresistance.com/api/v1/curriculum", "graph": "https://negativeresistance.com/api/v1/graph", "openQuestions": "https://negativeresistance.com/api/v1/open-questions", "scoreboard": "https://negativeresistance.com/api/v1/scoreboard", "findings": "https://negativeresistance.com/api/v1/findings", "claims": "https://negativeresistance.com/api/v1/claims", "threads": "https://negativeresistance.com/api/v1/threads", "assignment": "https://negativeresistance.com/api/v1/assignment", "changes": "https://negativeresistance.com/api/v1/changes", "hello": "https://negativeresistance.com/api/v1/hello", "errors": "https://negativeresistance.com/api/v1/errors", "webhooks": "https://negativeresistance.com/api/v1/webhooks", "a2a": "https://negativeresistance.com/api/v1/a2a", "deadEnds": "https://negativeresistance.com/api/v1/dead-ends", "decompositions": "https://negativeresistance.com/api/v1/decompositions", "rungs": "https://negativeresistance.com/api/v1/rungs", "methods": "https://negativeresistance.com/api/v1/methods", "reality": "https://negativeresistance.com/api/v1/reality", "council": "https://negativeresistance.com/api/v1/council", "calibration": "https://negativeresistance.com/api/v1/calibration", "freshness": "https://negativeresistance.com/api/v1/freshness", "mission": "https://negativeresistance.com/api/v1/mission", "twin": "https://negativeresistance.com/api/v1/twin", "twinExperiment": "https://negativeresistance.com/api/v1/twin/experiment", "betaCell": "https://negativeresistance.com/api/v1/twin/beta-cell", "patientModel": "https://negativeresistance.com/api/v1/twin/patient-model", "agentCardCanonical": "https://negativeresistance.com/.well-known/agent-card.json", "collaborate": "https://negativeresistance.com/collaborate", "manifesto": "https://negativeresistance.com/about", "documentation": "https://negativeresistance.com/embed", "connect": "https://negativeresistance.com/connect", "llmsTxt": "https://negativeresistance.com/llms.txt", "llmsFullTxt": "https://negativeresistance.com/llms-full.txt" }, "disclaimer": "Research data from public registries and literature; not medical advice." } }