{
  "data": {
    "asOf": "2026-10-30T22:26:03.095Z",
    "dedupMethod": "exact cross-registry identifier matching; probabilistic = review only",
    "byRegistry": {
      "clinicaltrials_gov": 1
    },
    "canonicalTrial": {
      "canonicalId": "NCT07892443",
      "title": "Type 2 Inflammation in Adults With Cystic Fibrosis",
      "scientificTitle": "Importance of Type 2 Inflammation in Adults With Cystic Fibrosis and Recurrent Pulmonary Exacerbations",
      "status": "not_yet_recruiting",
      "studyType": "observational",
      "phase": [],
      "conditions": [
        "Cystic Fibrosis (CF)",
        "Type 2 Inflammatory Disorders"
      ],
      "interventions": [],
      "sponsor": {
        "name": "University of Virginia",
        "type": "OTHER"
      },
      "locations": [],
      "outcomes": {
        "other": [],
        "primary": [
          "Baseline Stable-State Absolute Peripheral Blood Eosinophil Count"
        ],
        "secondary": [
          "Change in Nasal Epithelial Gene Expression from Baseline to Pulmonary Exacerbation",
          "Change in Exhaled Breath Condensate Inflammatory Mediator Concentrations from Baseline to Pulmonary Exacerbation",
          "Change in Peripheral Blood Immune Cell Phenotypes from Baseline to Pulmonary Exacerbation"
        ]
      },
      "eligibility": {
        "sex": "ALL",
        "criteria": "Inclusion Criteria:\n\n* Age 18 years or older\n* Diagnosis of cystic fibrosis\n* Receiving highly effective CFTR modulator therapy (HEMT) for at least 6 weeks before enrollment\n* Clinically stable at the time of enrollment\n* Receives cystic fibrosis care through the University of Virginia Adult Cystic Fibrosis Program\n* Able and willing to provide informed consent and participate in study procedures\n\nExclusion Criteria:\n\n* Active pulmonary exacerbation at the time of enrollment\n* Hospitalization for a pulmonary exacerbation within the 4 weeks before enrollment\n* New systemic antibiotic treatment for respiratory symptoms within the 4 weeks before enrollment\n* Systemic corticosteroid treatment for respiratory symptoms within the 4 weeks before enrollment\n* Pregnancy at the time of enrollment\n* Any condition that, in the opinion of the investigator, would make participation in the study unsafe or interfere with completion of study procedures",
        "minimumAge": "18 Years",
        "healthyVolunteers": false
      },
      "enrollment": {
        "type": "ESTIMATED",
        "count": 100
      },
      "startDate": "2026-11-01",
      "completionDate": "2031-05-31",
      "lastUpdated": "2026-10-23T00:00:00.000Z",
      "firstPosted": "2026-10-23T00:00:00.000Z",
      "resultsAvailable": false,
      "sourceRegistries": [
        "clinicaltrials_gov"
      ],
      "sourceUrls": [
        "https://clinicaltrials.gov/study/NCT07892443"
      ]
    },
    "identifiers": [
      {
        "idType": "nct",
        "idValue": "NCT07892443",
        "declaredBy": "clinicaltrials_gov"
      }
    ],
    "sourceRecords": [
      {
        "registry": "clinicaltrials_gov",
        "registryName": "ClinicalTrials.gov",
        "license": "public-domain",
        "sourceId": "NCT07892443",
        "sourceUrl": "https://clinicaltrials.gov/study/NCT07892443",
        "sourceStatus": "NOT_YET_RECRUITING",
        "retrievedAt": "2026-10-28T04:32:26.119Z",
        "payloadSha256": "cb2ee608d274b82caf9cffcc7d19907f450ae89e759ef5c11fbf537bf580eff4",
        "piiRedacted": true
      }
    ],
    "citation": {
      "canonicalId": "NCT07892443",
      "sources": [
        {
          "registry": "clinicaltrials_gov",
          "registryName": "ClinicalTrials.gov",
          "license": "public-domain",
          "sourceId": "NCT07892443",
          "verifyAt": "https://clinicaltrials.gov/study/NCT07892443",
          "retrievedAt": "2026-10-28T04:32:26.119Z",
          "payloadSha256": "cb2ee608d274b82caf9cffcc7d19907f450ae89e759ef5c11fbf537bf580eff4",
          "text": "ClinicalTrials.gov, record NCT07892443 (https://clinicaltrials.gov/study/NCT07892443), retrieved 2026-10-28, licence: public-domain."
        }
      ],
      "crossRegistry": false,
      "dedupMethod": "exact cross-registry identifier matching; probabilistic = review only",
      "text": "Trial NCT07892443, registered in ClinicalTrials.gov, retrieved 2026-10-28. Verify at the source URLs listed; each retrieval is checksummed.",
      "note": "Only one registry is known to hold this trial. Absence from the others is not evidence it was not registered there."
    },
    "provenanceNote": "Personal contact fields (names, emails, phone numbers, addresses) are stripped from every stored payload. No participant-level data is collected or served."
  },
  "_meta": {
    "api": "The Last Economy Wire: World Trials API",
    "version": "1.0",
    "schemaVersion": "1",
    "correlationId": "req_mYktwN3r9Dqc",
    "generatedAt": "2026-10-30T22:26:03.096Z",
    "documentation": "https://negativeresistance.com/embed",
    "license": "Free for any use. Attribution appreciated.",
    "degraded": false,
    "provenance": {
      "sources": [
        "clinicaltrials_gov"
      ],
      "attribution": {
        "clinicaltrials_gov": "ClinicalTrials.gov: licence: public-domain, https://clinicaltrials.gov/data-api/api-docs"
      },
      "dedupMethod": "exact cross-registry identifier matching; probabilistic = review only",
      "limitations": [],
      "provenanceEndpoint": "/api/v1/sources"
    },
    "freshness": {
      "newestEvidenceAt": null,
      "lastSyncedAt": {
        "clinicaltrials_gov": "2026-10-28T04:33:30.663Z"
      },
      "degradedSources": [],
      "worldwide": false,
      "maxAgeHours": 65.9,
      "fromCache": false
    },
    "links": {
      "discovery": "https://negativeresistance.com/api/v1",
      "openapi": "https://negativeresistance.com/api/v1/openapi.json",
      "mcp": "https://negativeresistance.com/api/v1/mcp",
      "agentCard": "https://negativeresistance.com/.well-known/agent.json",
      "aiPlugin": "https://negativeresistance.com/.well-known/ai-plugin.json",
      "sdk": "https://negativeresistance.com/api/v1/sdk",
      "status": "https://negativeresistance.com/api/v1/status",
      "provenance": "https://negativeresistance.com/api/v1/sources",
      "contract": "https://negativeresistance.com/api/v1/contract",
      "curriculum": "https://negativeresistance.com/api/v1/curriculum",
      "graph": "https://negativeresistance.com/api/v1/graph",
      "openQuestions": "https://negativeresistance.com/api/v1/open-questions",
      "scoreboard": "https://negativeresistance.com/api/v1/scoreboard",
      "findings": "https://negativeresistance.com/api/v1/findings",
      "claims": "https://negativeresistance.com/api/v1/claims",
      "threads": "https://negativeresistance.com/api/v1/threads",
      "assignment": "https://negativeresistance.com/api/v1/assignment",
      "changes": "https://negativeresistance.com/api/v1/changes",
      "hello": "https://negativeresistance.com/api/v1/hello",
      "errors": "https://negativeresistance.com/api/v1/errors",
      "webhooks": "https://negativeresistance.com/api/v1/webhooks",
      "a2a": "https://negativeresistance.com/api/v1/a2a",
      "deadEnds": "https://negativeresistance.com/api/v1/dead-ends",
      "decompositions": "https://negativeresistance.com/api/v1/decompositions",
      "rungs": "https://negativeresistance.com/api/v1/rungs",
      "methods": "https://negativeresistance.com/api/v1/methods",
      "reality": "https://negativeresistance.com/api/v1/reality",
      "council": "https://negativeresistance.com/api/v1/council",
      "calibration": "https://negativeresistance.com/api/v1/calibration",
      "freshness": "https://negativeresistance.com/api/v1/freshness",
      "mission": "https://negativeresistance.com/api/v1/mission",
      "twin": "https://negativeresistance.com/api/v1/twin",
      "twinExperiment": "https://negativeresistance.com/api/v1/twin/experiment",
      "betaCell": "https://negativeresistance.com/api/v1/twin/beta-cell",
      "patientModel": "https://negativeresistance.com/api/v1/twin/patient-model",
      "agentCardCanonical": "https://negativeresistance.com/.well-known/agent-card.json",
      "collaborate": "https://negativeresistance.com/collaborate",
      "manifesto": "https://negativeresistance.com/about",
      "documentation": "https://negativeresistance.com/embed",
      "connect": "https://negativeresistance.com/connect",
      "llmsTxt": "https://negativeresistance.com/llms.txt",
      "llmsFullTxt": "https://negativeresistance.com/llms-full.txt"
    },
    "disclaimer": "Research data from public registries and literature; not medical advice."
  }
}