{ "data": { "asOf": "2026-10-30T22:26:30.977Z", "dedupMethod": "exact cross-registry identifier matching; probabilistic = review only", "byRegistry": { "clinicaltrials_gov": 1 }, "canonicalTrial": { "canonicalId": "NCT07890753", "title": "Biological Aging Following Full-Arch Implant-Supported Fixed Rehabilitation in Edentulous Patients", "scientificTitle": "Association Between Full-Arch Implant-Supported Fixed Prosthetic Rehabilitation and Biological Aging in Edentulous Patients: A Prospective Cohort Study", "status": "not_yet_recruiting", "studyType": "observational", "phase": [], "conditions": [ "Edentulism", "Biological Aging" ], "interventions": [ { "name": "Full-Arch Implant-Supported Fixed Dental Rehabilitation", "type": "PROCEDURE", "description": "Full-arch implant-supported fixed dental rehabilitation is performed according to routine clinical indications and standard clinical practice. Treatment includes preoperative assessment, individualized implant treatment planning, dental implant placement, fabrication and delivery of implant-supported fixed prostheses, and postoperative clinical follow-up.\n\nThe decision to undergo treatment and the timing of rehabilitation are determined by the participants and their treating clinicians independently of the research protocol. Participants in the delayed-treatment comparison cohort voluntarily postpone treatment for approximately three months. The investigators do not assign treatment or determine treatment timing for research purposes." } ], "sponsor": { "name": "Junyu Shi", "type": "OTHER" }, "locations": [ { "city": "Shanghai", "country": "China", "facility": "Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine" } ], "outcomes": { "other": [], "primary": [ "Change in Salivary DNA Methylation Age Acceleration" ], "secondary": [ "Change in Facial Biological Age Acceleration", "Change in Handgrip Strength", "Change in Gait Speed", "Change in Physical Frailty", "Change in Oral Health-Related Quality of Life", "Change in Nutritional Status", "Change in Anxiety Symptoms Assessed by the Beck Anxiety Inventory (BAI)", "Change in Depressive Symptoms Assessed by the Beck Depression Inventory (BDI)", "Change in Global Cognitive Function", "Change in Information Processing Speed", "Change in Fine Motor Function", "Change in Resting-State EEG Measures", "Change in Brain Structure and Functional Connectivity", "Change in Cortical Hemodynamic Responses During Chewing" ] }, "eligibility": { "sex": "ALL", "criteria": "Inclusion Criteria:\n\n* Patients with complete edentulism.\n* Adults aged 50 years or older, regardless of sex.\n* Ability and willingness to complete the scheduled assessments at T0, T1, T2, and T3.\n* Eligibility for one of the following observational cohorts:\n* Implant rehabilitation cohort: Patients with complete edentulism who are clinically eligible for full-arch implant-supported fixed dental rehabilitation and plan to undergo treatment.\n* Delayed-treatment comparison cohort: Patients with complete edentulism who voluntarily choose to delay full-arch implant-supported fixed dental rehabilitation for approximately three months.\n\nExclusion Criteria:\n\n* Systemic diseases that may substantially affect bone metabolism or biological aging, such as severe diabetes mellitus or osteoporosis.\n* Recent use of bisphosphonates.\n* Severe neurological disorders, major psychiatric disorders, or serious systemic diseases that may substantially affect cognitive function, brain structure or function, or systemic aging biomarkers.\n* Any other condition or circumstance that prevents completion of the study procedures.", "minimumAge": "50 Years", "healthyVolunteers": false }, "enrollment": { "type": "ESTIMATED", "count": 60 }, "startDate": "2026-11-01", "completionDate": "2029-08-01", "lastUpdated": "2026-10-27T00:00:00.000Z", "firstPosted": "2026-10-22T00:00:00.000Z", "resultsAvailable": false, "sourceRegistries": [ "clinicaltrials_gov" ], "sourceUrls": [ "https://clinicaltrials.gov/study/NCT07890753" ] }, "identifiers": [ { "idType": "nct", "idValue": "NCT07890753", "declaredBy": "clinicaltrials_gov" } ], "sourceRecords": [ { "registry": "clinicaltrials_gov", "registryName": "ClinicalTrials.gov", "license": "public-domain", "sourceId": "NCT07890753", "sourceUrl": "https://clinicaltrials.gov/study/NCT07890753", "sourceStatus": "NOT_YET_RECRUITING", "retrievedAt": "2026-10-28T04:33:27.157Z", "payloadSha256": "731244f97d4166bad3bb0f9ce14a665ef5196c8830f54a1e1bbd16bd6d2fdf53", "piiRedacted": true } ], "citation": { "canonicalId": "NCT07890753", "sources": [ { "registry": "clinicaltrials_gov", "registryName": "ClinicalTrials.gov", "license": "public-domain", "sourceId": "NCT07890753", "verifyAt": "https://clinicaltrials.gov/study/NCT07890753", "retrievedAt": "2026-10-28T04:33:27.157Z", "payloadSha256": "731244f97d4166bad3bb0f9ce14a665ef5196c8830f54a1e1bbd16bd6d2fdf53", "text": "ClinicalTrials.gov, record NCT07890753 (https://clinicaltrials.gov/study/NCT07890753), retrieved 2026-10-28, licence: public-domain." } ], "crossRegistry": false, "dedupMethod": "exact cross-registry identifier matching; probabilistic = review only", "text": "Trial NCT07890753, registered in ClinicalTrials.gov, retrieved 2026-10-28. 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