{ "data": { "asOf": "2026-10-30T22:26:47.978Z", "dedupMethod": "exact cross-registry identifier matching; probabilistic = review only", "byRegistry": { "clinicaltrials_gov": 1 }, "canonicalTrial": { "canonicalId": "NCT07829497", "title": "Pain Phenotyping of Rheumatic Diseases - An Observational Study", "scientificTitle": "Pain Phenotyping of Rheumatic Diseases - An Observational Study", "status": "not_yet_recruiting", "studyType": "observational", "phase": [], "conditions": [ "Rheumatic Diseases", "Lupus Erythematosus, Systemic", "Lupus Vasculitis, Central Nervous System", "Arthritis", "Spondylarthritis", "Ankylosing Spondylarthritis", "Rheumatoid Arthritis", "Sjogren's Syndrome" ], "interventions": [ { "name": "Bedside quantitative sensory testing", "type": "DEVICE", "description": "It involves measuring a participant's response to standardized stimuli such as light touch, vibration, heat, cold, pressure, and sharp sensation. A qualified health professional will use various tools to stimulate the participant's nerves and record their response." } ], "sponsor": { "name": "National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)", "type": "NIH" }, "locations": [ { "city": "Bethesda", "country": "United States", "facility": "National Institutes of Health Clinical Center" } ], "outcomes": { "other": [], "primary": [ "Pain phenotype based on measurements from PRO's and bedside quantitative sensory testing (QST)." ], "secondary": [ "Quality of life" ] }, "eligibility": { "sex": "ALL", "criteria": "* INCLUSION CRITERIA\n\nInclusion Criteria for Subjects Suspected or Diagnosed with Rheumatic Diseases\n\nIn order to be eligible to participate in this study, an individual must meet all of the following criteria:\n\n1. Stated willingness to comply with all study procedures and availability for the duration of the study\n2. Aged 9-85 years\n3. Diagnosed or suspected of having a rheumatic disease.\n4. Ability of the subject to understand and the willingness to sign a written informed consent document or assent.\n5. Must be enrolled in one of the NIAMS protocols (01-AR-0227, 94-AR-0066, 11-AR-0223)\n6. To be able to answer PRO questionnaires in either English and/or Spanish languages.\n\nInclusion Criteria Healthy Volunteers\n\n1. Stated willingness to comply with all study procedures and availability for the duration of the study\n2. Aged 9-85 years\n3. No known history of a rheumatic disease or any other chronic medical illness.\n4. Ability of the subject to understand and the willingness to sign a written informed consent document or assent.\n5. To be enrolled in either of the ongoing NIAMS protocols 01-AR-0227, 94-AR-0066, or 11-AR-0223.\n6. To be able to answer PRO questionnaires in either English and/or Spanish languages.\n\nEXCLUSION CRITERIA\n\nAn individual who meets any of the following criteria will be excluded from participation in this study:\n\n1. Treatment with investigational drug or other investigational intervention while enrolled in this study.\n2. Any physical exam finding that precludes bedside QST.\n3. Developmental delay or cognitive impairment that interfere with following or understanding the test instructions.\n4. Subjects using illicit or street drugs will be excluded. Subjects taking prescribed pain medications will not be excluded.\n5. 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