{ "data": { "asOf": "2026-10-30T22:24:47.040Z", "dedupMethod": "exact cross-registry identifier matching; probabilistic = review only", "byRegistry": { "clinicaltrials_gov": 1 }, "canonicalTrial": { "canonicalId": "NCT07787182", "title": "A Study of LY4405094 in Healthy Participants and Participants With Alzheimer's Disease", "scientificTitle": "A Placebo-Controlled, Single- and Multiple-Ascending Dose, Phase 1 Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of LY4405094 in Healthy Participants and Participants With Alzheimer's Disease", "status": "recruiting", "studyType": "interventional", "phase": [ "PHASE1" ], "conditions": [ "Healthy Volunteers", "Alzheimer Disease", "Amyloid", "Plaque, Amyloid" ], "interventions": [ { "name": "LY4405094", "type": "DRUG", "description": "Administered intravenously (IV)" }, { "name": "LY4405094", "type": "DRUG", "description": "Administered Subcutaneously (SC)" }, { "name": "Placebo", "type": "DRUG", "description": "Administered IV" }, { "name": "Placebo", "type": "DRUG", "description": "Administered SC" }, { "name": "Florbetapir F18", "type": "OTHER", "description": "Administered IV" }, { "name": "Florbetaben F 18", "type": "OTHER", "description": "Administered IV" } ], "sponsor": { "name": "Eli Lilly and Company", "type": "INDUSTRY" }, "locations": [ { "city": "Anaheim", "country": "United States", "facility": "CenExel ACT" }, { "city": "Irvine", "country": "United States", "facility": "Irvine Clinical Research" }, { "city": "Los Alamitos", "country": "United States", "facility": "Collaborative Neuroscience Network - CNS" }, { "city": "Daytona Beach", "country": "United States", "facility": "Fortrea Clinical Research Unit" }, { "city": "Lady Lake", "country": "United States", "facility": "K2 Medical Research - The Villages" }, { "city": "Maitland", "country": "United States", "facility": "K2 Medical Research" }, { "city": "Orlando", "country": "United States", "facility": "Charter Research" }, { "city": "Port Orange", "country": "United States", "facility": "Progressive Medical Research" }, { "city": "Stuart", "country": "United States", "facility": "Alzheimer's Research and Treatment Center" }, { "city": "Tampa", "country": "United States", "facility": "K2 Medical Research - Tampa" }, { "city": "The Villages", "country": "United States", "facility": "Charter Research" }, { "city": "Decatur", "country": "United States", "facility": "Accel Research Sites - NeuroStudies Clinical Research Unit" }, { "city": "Farmington Hills", "country": "United States", "facility": "QUEST Research Institute" }, { "city": "Beijing", "country": "China", "facility": "Xuanwu Hospital Capital Medical University" }, { "city": "Minhang District", "country": "China", "facility": "Huashan Hospital, Fudan University" }, { "city": "Shanghai", "country": "China", "facility": "Renji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine" }, { "city": "Bunkyō City", "country": "Japan", "facility": "The University of Tokyo Hospital" }, { "city": "Ōbu", "country": "Japan", "facility": "National Center for Geriatrics and Gerontology" } ], "outcomes": { "other": [], "primary": [ "Number of Participants with One or More Serious Adverse Event(s) (SAEs) Considered by the Investigator to be Related to Study Drug Administration" ], "secondary": [ "Pharmacokinetics (PK): Maximum Concentration (Cmax) of LY4405094 in Healthy Participants", "PK: Area Under the Concentration Versus Time Curve (AUC) of LY4405094 in Participants with Alzheimer's Disease (AD)", "Change from Baseline of Cerebrospinal Fluid (CSF) Concentration of LY4405094 in Healthy Participants", "Change from Baseline of Amyloid Plaque levels as Assessed by Amyloid Positron Emission Tomography (PET) in Participants with AD" ] }, "eligibility": { "sex": "ALL", "criteria": "Inclusion Criteria:\n\n* Participants must meet eligibility criteria in the ATMP screening protocol before entry into the treatment study.\n\nExclusion Criteria:\n\n* Have known allergies to LY4405094, related compounds (including remternetug), or any components of the formulation, including LY4405094.\n* Have known allergic reactions to adhesive or hydrogels or a family history of adhesive skin allergies.", "maximumAge": "85 Years", "minimumAge": "18 Years", "healthyVolunteers": true }, "enrollment": { "type": "ESTIMATED", "count": 68 }, "startDate": "2025-10-14", "completionDate": "2028-01-01", "lastUpdated": "2026-10-22T00:00:00.000Z", "firstPosted": "2026-08-26T00:00:00.000Z", "resultsAvailable": false, "sourceRegistries": [ "clinicaltrials_gov" ], "sourceUrls": [ "https://clinicaltrials.gov/study/NCT07787182" ] }, "identifiers": [ { "idType": "nct", "idValue": "NCT07787182", "declaredBy": "clinicaltrials_gov" }, { "idType": "euct", "idValue": "2026-527295-81-00", "declaredBy": "clinicaltrials_gov" } ], "sourceRecords": [ { "registry": "clinicaltrials_gov", "registryName": "ClinicalTrials.gov", "license": "public-domain", "sourceId": "NCT07787182", "sourceUrl": "https://clinicaltrials.gov/study/NCT07787182", "sourceStatus": "RECRUITING", "retrievedAt": "2026-10-28T04:32:51.103Z", "payloadSha256": "5d1b53c359f9966749f900efda45ed6f5c9d70bdc6ee50a30f41d9ca0e63da22", "piiRedacted": true } ], "citation": { "canonicalId": "NCT07787182", "sources": [ { "registry": "clinicaltrials_gov", "registryName": "ClinicalTrials.gov", "license": "public-domain", "sourceId": "NCT07787182", "verifyAt": "https://clinicaltrials.gov/study/NCT07787182", "retrievedAt": "2026-10-28T04:32:51.103Z", "payloadSha256": "5d1b53c359f9966749f900efda45ed6f5c9d70bdc6ee50a30f41d9ca0e63da22", "text": "ClinicalTrials.gov, record NCT07787182 (https://clinicaltrials.gov/study/NCT07787182), retrieved 2026-10-28, licence: public-domain." } ], "crossRegistry": false, "dedupMethod": "exact cross-registry identifier matching; probabilistic = review only", "text": "Trial NCT07787182, registered in ClinicalTrials.gov, retrieved 2026-10-28. Verify at the source URLs listed; each retrieval is checksummed.", "note": "Only one registry is known to hold this trial. Absence from the others is not evidence it was not registered there." }, "provenanceNote": "Personal contact fields (names, emails, phone numbers, addresses) are stripped from every stored payload. No participant-level data is collected or served." }, "_meta": { "api": "The Last Economy Wire: World Trials API", "version": "1.0", "schemaVersion": "1", "correlationId": "req_cdChxtqcTqsk", "generatedAt": "2026-10-30T22:24:47.040Z", "documentation": "https://negativeresistance.com/embed", "license": "Free for any use. Attribution appreciated.", "degraded": false, "provenance": { "sources": [ "clinicaltrials_gov" ], "attribution": { "clinicaltrials_gov": "ClinicalTrials.gov: licence: public-domain, https://clinicaltrials.gov/data-api/api-docs" }, "dedupMethod": "exact cross-registry identifier matching; probabilistic = review only", "limitations": [], "provenanceEndpoint": "/api/v1/sources" }, "freshness": { "newestEvidenceAt": null, "lastSyncedAt": { "clinicaltrials_gov": "2026-10-28T04:33:30.663Z" }, "degradedSources": [], "worldwide": false, "maxAgeHours": 65.9, "fromCache": false }, "links": { "discovery": "https://negativeresistance.com/api/v1", "openapi": "https://negativeresistance.com/api/v1/openapi.json", "mcp": "https://negativeresistance.com/api/v1/mcp", "agentCard": "https://negativeresistance.com/.well-known/agent.json", "aiPlugin": "https://negativeresistance.com/.well-known/ai-plugin.json", "sdk": "https://negativeresistance.com/api/v1/sdk", "status": "https://negativeresistance.com/api/v1/status", "provenance": "https://negativeresistance.com/api/v1/sources", "contract": "https://negativeresistance.com/api/v1/contract", "curriculum": "https://negativeresistance.com/api/v1/curriculum", "graph": "https://negativeresistance.com/api/v1/graph", "openQuestions": "https://negativeresistance.com/api/v1/open-questions", "scoreboard": "https://negativeresistance.com/api/v1/scoreboard", "findings": "https://negativeresistance.com/api/v1/findings", "claims": "https://negativeresistance.com/api/v1/claims", "threads": "https://negativeresistance.com/api/v1/threads", "assignment": "https://negativeresistance.com/api/v1/assignment", "changes": "https://negativeresistance.com/api/v1/changes", "hello": "https://negativeresistance.com/api/v1/hello", "errors": "https://negativeresistance.com/api/v1/errors", "webhooks": "https://negativeresistance.com/api/v1/webhooks", "a2a": "https://negativeresistance.com/api/v1/a2a", "deadEnds": "https://negativeresistance.com/api/v1/dead-ends", "decompositions": "https://negativeresistance.com/api/v1/decompositions", "rungs": "https://negativeresistance.com/api/v1/rungs", "methods": "https://negativeresistance.com/api/v1/methods", "reality": "https://negativeresistance.com/api/v1/reality", "council": "https://negativeresistance.com/api/v1/council", "calibration": "https://negativeresistance.com/api/v1/calibration", "freshness": "https://negativeresistance.com/api/v1/freshness", "mission": "https://negativeresistance.com/api/v1/mission", "twin": "https://negativeresistance.com/api/v1/twin", "twinExperiment": "https://negativeresistance.com/api/v1/twin/experiment", "betaCell": "https://negativeresistance.com/api/v1/twin/beta-cell", "patientModel": "https://negativeresistance.com/api/v1/twin/patient-model", "agentCardCanonical": "https://negativeresistance.com/.well-known/agent-card.json", "collaborate": "https://negativeresistance.com/collaborate", "manifesto": "https://negativeresistance.com/about", "documentation": "https://negativeresistance.com/embed", "connect": "https://negativeresistance.com/connect", "llmsTxt": "https://negativeresistance.com/llms.txt", "llmsFullTxt": "https://negativeresistance.com/llms-full.txt" }, "disclaimer": "Research data from public registries and literature; not medical advice." } }