{ "data": { "asOf": "2026-10-30T22:26:47.329Z", "dedupMethod": "exact cross-registry identifier matching; probabilistic = review only", "byRegistry": { "clinicaltrials_gov": 1 }, "canonicalTrial": { "canonicalId": "NCT07754019", "title": "Serum and Urinary sCD163 in IgA Nephropathy", "scientificTitle": "Association of Serum and Urinary Soluble CD163 Levels With Disease Activity, Histopathologic Severity, and Prognosis in Patients With IgA Nephropathy: A Single-Center Observational Study", "status": "completed", "studyType": "observational", "phase": [], "conditions": [ "IgA Nephropathy" ], "interventions": [], "sponsor": { "name": "Bezmialem Vakif University", "type": "OTHER" }, "locations": [ { "city": "Istanbul", "country": "Turkey (Türkiye)", "facility": "Bezmialem Vakif University Health Application and Research Center" } ], "outcomes": { "other": [], "primary": [ "Comparison of Serum and Urinary Soluble CD163 Levels Among IgAN, FSGS, and Healthy Control Groups" ], "secondary": [ "Association of Soluble CD163 Levels With Clinical Disease Activity in IgA Nephropathy", "Association of Soluble CD163 Levels With Histopathologic Severity" ] }, "eligibility": { "sex": "ALL", "criteria": "Inclusion Criteria:\n\n* \\- Age 18 years or older\n* Biopsy-proven primary IgA nephropathy or primary focal segmental glomerulosclerosis\n* Stable kidney function with an estimated glomerular filtration rate greater than 30 mL/min/1.73 m²\n* Availability of serum and urine samples for soluble CD163 measurement\n* Availability of relevant demographic, clinical, laboratory, histopathologic, and follow-up data\n* For the healthy control group: age- and sex-matched individuals without known chronic disease and with normal kidney function\n* Written informed consent\n\nExclusion Criteria:\n\n* \\- Secondary IgA nephropathy or secondary focal segmental glomerulosclerosis\n* Active infection\n* Acute kidney injury\n* End-stage kidney disease or ongoing dialysis treatment\n* Estimated glomerular filtration rate below 15 mL/min/1.73 m²\n* Recent use of corticosteroids or immunosuppressive therapy\n* Pregnancy\n* Active malignancy or history of malignancy\n* Inadequately stored or unavailable serum and/or urine samples\n* Missing essential clinical, laboratory, histopathologic, or follow-up data\n* Absence of written informed consent", "minimumAge": "18 Years", "healthyVolunteers": true }, "enrollment": { "type": "ACTUAL", "count": 87 }, "startDate": "2025-02-03", "completionDate": "2026-09-01", "lastUpdated": "2026-10-27T00:00:00.000Z", "firstPosted": "2026-08-10T00:00:00.000Z", "resultsAvailable": false, "sourceRegistries": [ "clinicaltrials_gov" ], "sourceUrls": [ "https://clinicaltrials.gov/study/NCT07754019" ] }, "identifiers": [ { "idType": "nct", "idValue": "NCT07754019", "declaredBy": "clinicaltrials_gov" } ], "sourceRecords": [ { "registry": "clinicaltrials_gov", "registryName": "ClinicalTrials.gov", "license": "public-domain", "sourceId": "NCT07754019", "sourceUrl": "https://clinicaltrials.gov/study/NCT07754019", "sourceStatus": "COMPLETED", "retrievedAt": "2026-10-28T04:33:03.123Z", "payloadSha256": "e0960cc94df856207ef01d96dc2a1f44b4d0ef42af95f812cf1b052d62d4ab88", "piiRedacted": true } ], "citation": { "canonicalId": "NCT07754019", "sources": [ { "registry": "clinicaltrials_gov", "registryName": "ClinicalTrials.gov", "license": "public-domain", "sourceId": "NCT07754019", "verifyAt": "https://clinicaltrials.gov/study/NCT07754019", "retrievedAt": "2026-10-28T04:33:03.123Z", "payloadSha256": "e0960cc94df856207ef01d96dc2a1f44b4d0ef42af95f812cf1b052d62d4ab88", "text": "ClinicalTrials.gov, record NCT07754019 (https://clinicaltrials.gov/study/NCT07754019), retrieved 2026-10-28, licence: public-domain." } ], "crossRegistry": false, "dedupMethod": "exact cross-registry identifier matching; probabilistic = review only", "text": "Trial NCT07754019, registered in ClinicalTrials.gov, retrieved 2026-10-28. Verify at the source URLs listed; each retrieval is checksummed.", "note": "Only one registry is known to hold this trial. Absence from the others is not evidence it was not registered there." }, "provenanceNote": "Personal contact fields (names, emails, phone numbers, addresses) are stripped from every stored payload. No participant-level data is collected or served." }, "_meta": { "api": "The Last Economy Wire: World Trials API", "version": "1.0", "schemaVersion": "1", "correlationId": "req_2r1DWaibRw_x", "generatedAt": "2026-10-30T22:26:47.329Z", "documentation": "https://negativeresistance.com/embed", "license": "Free for any use. Attribution appreciated.", "degraded": false, "provenance": { "sources": [ "clinicaltrials_gov" ], "attribution": { "clinicaltrials_gov": "ClinicalTrials.gov: licence: public-domain, https://clinicaltrials.gov/data-api/api-docs" }, "dedupMethod": "exact cross-registry identifier matching; probabilistic = review only", "limitations": [], "provenanceEndpoint": "/api/v1/sources" }, "freshness": { "newestEvidenceAt": null, "lastSyncedAt": { "clinicaltrials_gov": "2026-10-28T04:33:30.663Z" }, "degradedSources": [], "worldwide": false, "maxAgeHours": 65.9, "fromCache": false }, "links": { "discovery": "https://negativeresistance.com/api/v1", "openapi": "https://negativeresistance.com/api/v1/openapi.json", "mcp": "https://negativeresistance.com/api/v1/mcp", "agentCard": "https://negativeresistance.com/.well-known/agent.json", "aiPlugin": "https://negativeresistance.com/.well-known/ai-plugin.json", "sdk": "https://negativeresistance.com/api/v1/sdk", "status": "https://negativeresistance.com/api/v1/status", "provenance": "https://negativeresistance.com/api/v1/sources", "contract": "https://negativeresistance.com/api/v1/contract", "curriculum": "https://negativeresistance.com/api/v1/curriculum", "graph": "https://negativeresistance.com/api/v1/graph", "openQuestions": "https://negativeresistance.com/api/v1/open-questions", "scoreboard": "https://negativeresistance.com/api/v1/scoreboard", "findings": "https://negativeresistance.com/api/v1/findings", "claims": "https://negativeresistance.com/api/v1/claims", "threads": "https://negativeresistance.com/api/v1/threads", "assignment": "https://negativeresistance.com/api/v1/assignment", "changes": "https://negativeresistance.com/api/v1/changes", "hello": "https://negativeresistance.com/api/v1/hello", "errors": "https://negativeresistance.com/api/v1/errors", "webhooks": "https://negativeresistance.com/api/v1/webhooks", "a2a": "https://negativeresistance.com/api/v1/a2a", "deadEnds": "https://negativeresistance.com/api/v1/dead-ends", "decompositions": "https://negativeresistance.com/api/v1/decompositions", "rungs": "https://negativeresistance.com/api/v1/rungs", "methods": "https://negativeresistance.com/api/v1/methods", "reality": "https://negativeresistance.com/api/v1/reality", "council": "https://negativeresistance.com/api/v1/council", "calibration": "https://negativeresistance.com/api/v1/calibration", "freshness": "https://negativeresistance.com/api/v1/freshness", "mission": "https://negativeresistance.com/api/v1/mission", "twin": "https://negativeresistance.com/api/v1/twin", "twinExperiment": "https://negativeresistance.com/api/v1/twin/experiment", "betaCell": "https://negativeresistance.com/api/v1/twin/beta-cell", "patientModel": "https://negativeresistance.com/api/v1/twin/patient-model", "agentCardCanonical": "https://negativeresistance.com/.well-known/agent-card.json", "collaborate": "https://negativeresistance.com/collaborate", "manifesto": "https://negativeresistance.com/about", "documentation": "https://negativeresistance.com/embed", "connect": "https://negativeresistance.com/connect", "llmsTxt": "https://negativeresistance.com/llms.txt", "llmsFullTxt": "https://negativeresistance.com/llms-full.txt" }, "disclaimer": "Research data from public registries and literature; not medical advice." } }