{ "data": { "asOf": "2026-10-30T22:24:35.558Z", "dedupMethod": "exact cross-registry identifier matching; probabilistic = review only", "byRegistry": { "clinicaltrials_gov": 1 }, "canonicalTrial": { "canonicalId": "NCT07697456", "title": "Study of Advanced Therapies for the Treatment of Adult Participants With Moderately to Severely Active Crohn's Disease or Ulcerative Colitis", "scientificTitle": "A Phase 2 Platform Basket Study Evaluating Advanced Therapies in Subjects With Moderately to Severely Active Crohn's Disease or Ulcerative Colitis", "status": "recruiting", "studyType": "interventional", "phase": [ "PHASE2" ], "conditions": [ "Crohn's Disease", "Ulcerative Colitis" ], "interventions": [ { "name": "Risankizumab", "type": "DRUG", "description": "Intravenous/Subcutaneous/Intramuscular Injection/Infusion" }, { "name": "Trosunilimab", "type": "DRUG", "description": "Intravenous/Subcutaneous/Intramuscular Injection/Infusion" }, { "name": "ABBV-701", "type": "DRUG", "description": "Intravenous/Subcutaneous/Intramuscular Injection/Infusion" } ], "sponsor": { "name": "AbbVie", "type": "INDUSTRY" }, "locations": [ { "city": "Dothan", "country": "United States", "facility": "Digestive Health Specialists /ID# 280827" }, { "city": "Phoenix", "country": "United States", "facility": "Elite Clinical Studies /ID# 280477" }, { "city": "Sun City", "country": "United States", "facility": "Gi Alliance - Arizona Digestive Health - Sun City /ID# 284084" }, { "city": "Anaheim", "country": "United States", "facility": "Clinnova Research /ID# 280509" }, { "city": "Coronado", "country": "United States", "facility": "Southern California Res. Ctr /ID# 280476" }, { "city": "Lancaster", "country": "United States", "facility": "Gastro Care Institute /ID# 281071" }, { "city": "Los Alamitos", "country": "United States", "facility": "United Medical Doctors - Los Alamitos /ID# 281125" }, { "city": "Rialto", "country": "United States", "facility": "Inland Empire Liver Foundation - Rialto /ID# 280775" }, { "city": "Colorado Springs", "country": "United States", "facility": "Peak Gastroenterology Associates - Colorado Springs - North Cascade Avenue /ID# 280507" }, { "city": "Bradenton", "country": "United States", "facility": "Synergy Healthcare - Bradenton /ID# 284157" }, { "city": "Kissimmee", "country": "United States", "facility": "Clinical Research of Osceola /ID# 280593" }, { "city": "Largo", "country": "United States", "facility": "Florida Center For Gastroenterology - Largo /ID# 281059" }, { "city": "Miami", "country": "United States", "facility": "Research Associates of South Florida /ID# 280929" }, { "city": "New Port Richey", "country": "United States", "facility": "Advanced Research Institute, Inc /ID# 281062" }, { "city": "Orlando", "country": "United States", "facility": "Digestive And Liver Center Of Florida - Orlando /ID# 280924" }, { "city": "Tampa", "country": "United States", "facility": "Gcp Clinical Research /ID# 280469" }, { "city": "Macon", "country": "United States", "facility": "Gastroenterology Associates of Central Georgia /ID# 280464" }, { "city": "Roswell", "country": "United States", "facility": "Gastroenterology Consultants - Roswell /ID# 281235" }, { "city": "Boise", "country": "United States", "facility": "Treasure Valley Medical Research /ID# 281778" }, { "city": "Des Plaines", "country": "United States", "facility": "Midwest Digestive Health & Nutrition /ID# 285250" }, { "city": "Glenview", "country": "United States", "facility": "Gi Alliance - Glenview /ID# 283932" }, { "city": "Gurnee", "country": "United States", "facility": "Illinois Gastroenterology Group /ID# 283933" }, { "city": "Oak Lawn", "country": "United States", "facility": "Southwest Gastroenterology - Oak Lawn /ID# 280841" }, { "city": "New Albany", "country": "United States", "facility": "Gastroenterology Health Partners /ID# 284145" }, { "city": "Louisville", "country": "United States", "facility": "Gastroenterology Health Partners /ID# 284144" }, { "city": "Mandeville", "country": "United States", "facility": "Gastro Group and Endocenter: Mandeville, la /ID# 284186" }, { "city": "Metairie", "country": "United States", "facility": "Metropolitan Gastroenterology Associates - Metairie /ID# 283922" }, { "city": "Shreveport", "country": "United States", "facility": "Willis-Knighton Medical Center /ID# 280572" }, { "city": "New Bedford", "country": "United States", "facility": "Lucida Clinical Trials /ID# 282000" }, { "city": "Wyoming", "country": "United States", "facility": "West Michigan Clinical Research Center /ID# 280480" }, { "city": "Flowood", "country": "United States", "facility": "Gi Associates - Gia And Endoscopy Center - Flowood /ID# 283967" }, { "city": "Oxford", "country": "United States", "facility": "Gastroenterology Associates Of North Mississippi /ID# 285243" }, { "city": "St Louis", "country": "United States", "facility": "Specialists In Gastroenterology /ID# 283939" }, { "city": "Las Vegas", "country": "United States", "facility": "Vector Clinical Trials /ID# 280843" }, { "city": "New York", "country": "United States", "facility": "New York Gastroenterology Associates - Upper East Side /ID# 281767" }, { "city": "Asheville", "country": "United States", "facility": "Digestive Health Partners /ID# 280490" }, { "city": "Beavercreek", "country": "United States", "facility": "Dayton Gastroenterology - Beavercreek /ID# 284065" }, { "city": "Westlake", "country": "United States", "facility": "Gastro Intestinal Research Institute of Northern Ohio /ID# 283860" }, { "city": "Providence", "country": "United States", "facility": "University Gastroenterology - Providence - Staniford Street /ID# 280919" }, { "city": "Greenville", "country": "United States", "facility": "Gastroenterology Associates - Patewood /ID# 283870" }, { "city": "Knoxville", "country": "United States", "facility": "Gastrointestinal Associates - Knoxville - Dowell Springs Boulevard /ID# 283861" }, { "city": "Memphis", "country": "United States", "facility": "Gastro One - Memphis /ID# 283948" }, { "city": "Bellaire", "country": "United States", "facility": "Novel Research - Bellaire /ID# 280925" }, { "city": "Fort Worth", "country": "United States", "facility": "Gi Alliance - Texas Digestive Disease Consultants - Fort Worth /ID# 283977" }, { "city": "Garland", "country": "United States", "facility": "GI Alliance -Garland /ID# 284253" }, { "city": "Georgetown", "country": "United States", "facility": "Amel Med /ID# 283864" }, { "city": "Houston", "country": "United States", "facility": "Integrity Advanced Therapeutics /ID# 283871" }, { "city": "Lubbock", "country": "United States", "facility": "GI Alliance - Lubbock /ID# 283920" }, { "city": "Lubbock", "country": "United States", "facility": "Caprock Gastro Research - Lubbock /ID# 283921" }, { "city": "Mansfield", "country": "United States", "facility": "GI Alliance - Mansfield /ID# 283924" }, { "city": "San Antonio", "country": "United States", "facility": "Southern Star Research Institute /ID# 280822" }, { "city": "Shenandoah", "country": "United States", "facility": "Center for Digestive Disease /ID# 280870" }, { "city": "Southlake", "country": "United States", "facility": "Texas Digestive Disease Consultants - Southlake /ID# 283931" }, { "city": "Tyler", "country": "United States", "facility": "Tyler Research Institute /ID# 284247" }, { "city": "Webster", "country": "United States", "facility": "Texas Digestive Disease Consultants /ID# 284245" }, { "city": "Lansdowne Town Center", "country": "United States", "facility": "Emeritas Research Group /ID# 284388" }, { "city": "Richmond", "country": "United States", "facility": "GI Alliance - Richmond /ID# 284244" }, { "city": "Bellevue", "country": "United States", "facility": "Washington Gastroenterology - Bellevue /ID# 283966" }, { "city": "Tacoma", "country": "United States", "facility": "Washington Gastroenterology - Tacoma /ID# 284143" }, { "city": "Vancouver", "country": "United States", "facility": "The Vancouver Clinic /ID# 280497" }, { "city": "Milwaukee", "country": "United States", "facility": "Wisconsin Center for Advanced Research /ID# 284250" }, { "city": "Québec", "country": "Canada", "facility": "Diex Recherche Quebec Inc. /ID# 282307" }, { "city": "Ashdod", "country": "Israel", "facility": "Assuta Ashdod Medical Center /ID# 280535" }, { "city": "Kure", "country": "Japan", "facility": "Kure Kyosai Hospital /ID# 282006" }, { "city": "Kaohsiung City", "country": "Taiwan", "facility": "Kaohsiung Medical University Chung-Ho Memorial Hospital /ID# 280640" }, { "city": "Taichung", "country": "Taiwan", "facility": "China Medical University Hospital /ID# 280630" } ], "outcomes": { "other": [], "primary": [ "Crohn's Disease Specific: Percentage of Participants Achieving Endoscopic Remission", "Ulcerative Colitis Specific: Percentage of Participants who Achieve Endoscopic Remission", "Number of Participants with Adverse Events (AEs)" ], "secondary": [ "Crohn's Disease Specific: Percentage of Participants who Achieve Endoscopic Remission", "Crohn's Disease Specific: Percentage of Participants who Achieve Endoscopic Response", "Crohn's Disease Specific: Percentage of Participants who Achieve Endoscopic Response", "Crohn's Disease Specific: Percentage of Participants Achieving CDAI Clinical Remission", "Crohn's Disease Specific: Percentage of Participants Achieving CDAI Clinical Remission", "Crohn's Disease Specific: Percentage of Participants With Clinical Remission Per Stool Frequency/Abdominal Pain Score (SF/APS)", "Crohn's Disease Specific: Percentage of Participants With Clinical Remission Per Stool Frequency/Abdominal Pain Score (SF/APS)", "Ulcerative Colitis Specific: Percentage of Participants with Clinical Remission per modified Mayo Score (mMS)", "Ulcerative Colitis Specific: Percentage of Participants with Clinical Remission per mMS", "Ulcerative Colitis Specific: Percentage of Participants who Achieve Endoscopic Remission", "Ulcerative Colitis Specific: Percentage of Participants Achieving Endoscopic Improvement", "Ulcerative Colitis Specific: Percentage of Participants Achieving Endoscopic Improvement", "Ulcerative Colitis Specific: Percentage of Participants who Achieve Clinical Response Per mMS", "Ulcerative Colitis Specific: Percentage of Participants who Achieve Clinical Response Per mMS" ] }, "eligibility": { "sex": "ALL", "criteria": "Inclusion Criteria:\n\nCD specific:\n\n* Crohn's Disease Activity Index (CDAI) score of ≥ 220\n* Confirmed diagnosis of CD at least 90 days prior to Baseline\n* Endoscopic evidence of mucosal inflammation as documented by an Simple Endoscopic Score for Crohn's Disease (SES-CD) of ≥ 6 for ileocolonic or colonic disease or SES-CD of ≥ 4 for isolated ileal disease.\n* Demonstrated failure of 1 or more therapy for CD\n\nUC specific:\n\n* Confirmed diagnosis of UC at least 90 days prior to Baseline\n* Active UC with a modified Mayo Score (mMS) of 5 to 9 points and endoscopic subscore (ESS) of 2 to 3\n* Demonstrated failure of 1 or more therapy for UC\n\nExclusion Criteria:\n\n* Participants with demonstrated intolerance to p19 IL-23 inhibitors (including risankizumab)\n* Participants treated with any investigational drug within 30 days or 5 half-lives of the study treatments (whichever is longer) prior to the first dose of study treatment\n* Participants who received any ATs (biologic or small molecules) prior to first dose of study treatment within the protocol specified time frame\n* Participants with surgical bowel resection within the past 3 months prior to Baseline\n\nCD specific:\n\n* Participants with \\>3 prior bowel resections\n* Participants with previous small bowel resection(s) of combined length \\>100 cm\n\nUC specific:\n\n* Participants with prior colectomy (total or subtotal)\n* Participants with extent of disease limited to \\< 10 cm of rectum", "maximumAge": "75 Years", "minimumAge": "18 Years", "healthyVolunteers": false }, "enrollment": { "type": "ESTIMATED", "count": 2000 }, "startDate": "2026-07-31", "completionDate": "2031-10-01", "lastUpdated": "2026-10-27T00:00:00.000Z", "firstPosted": "2026-07-13T00:00:00.000Z", "resultsAvailable": false, "sourceRegistries": [ "clinicaltrials_gov" ], "sourceUrls": [ "https://clinicaltrials.gov/study/NCT07697456" ] }, "identifiers": [ { "idType": "nct", "idValue": "NCT07697456", "declaredBy": "clinicaltrials_gov" }, { "idType": "euct", "idValue": "2026-525960-16-00", "declaredBy": "clinicaltrials_gov" }, { "idType": "euct", "idValue": "2026-525959-86-00", "declaredBy": "clinicaltrials_gov" } ], "sourceRecords": [ { "registry": "clinicaltrials_gov", "registryName": "ClinicalTrials.gov", "license": "public-domain", "sourceId": "NCT07697456", "sourceUrl": "https://clinicaltrials.gov/study/NCT07697456", "sourceStatus": "RECRUITING", "retrievedAt": "2026-10-28T04:32:56.396Z", "payloadSha256": "bf3992201925126b8a0ac41bb3c5ae848b30eacc0161a65db91c3ecd6ded5147", "piiRedacted": true } ], "citation": { "canonicalId": "NCT07697456", "sources": [ { "registry": "clinicaltrials_gov", "registryName": "ClinicalTrials.gov", "license": "public-domain", "sourceId": "NCT07697456", "verifyAt": "https://clinicaltrials.gov/study/NCT07697456", "retrievedAt": "2026-10-28T04:32:56.396Z", "payloadSha256": "bf3992201925126b8a0ac41bb3c5ae848b30eacc0161a65db91c3ecd6ded5147", "text": "ClinicalTrials.gov, record NCT07697456 (https://clinicaltrials.gov/study/NCT07697456), retrieved 2026-10-28, licence: public-domain." } ], "crossRegistry": false, "dedupMethod": "exact cross-registry identifier matching; probabilistic = review only", "text": "Trial NCT07697456, registered in ClinicalTrials.gov, retrieved 2026-10-28. Verify at the source URLs listed; each retrieval is checksummed.", "note": "Only one registry is known to hold this trial. Absence from the others is not evidence it was not registered there." }, "provenanceNote": "Personal contact fields (names, emails, phone numbers, addresses) are stripped from every stored payload. No participant-level data is collected or served." }, "_meta": { "api": "The Last Economy Wire: World Trials API", "version": "1.0", "schemaVersion": "1", "correlationId": "req_CSzoCYVOR9oI", "generatedAt": "2026-10-30T22:24:35.558Z", "documentation": "https://negativeresistance.com/embed", "license": "Free for any use. Attribution appreciated.", "degraded": false, "provenance": { "sources": [ "clinicaltrials_gov" ], "attribution": { "clinicaltrials_gov": "ClinicalTrials.gov: licence: public-domain, https://clinicaltrials.gov/data-api/api-docs" }, "dedupMethod": "exact cross-registry identifier matching; probabilistic = review only", "limitations": [], "provenanceEndpoint": "/api/v1/sources" }, "freshness": { "newestEvidenceAt": null, "lastSyncedAt": { "clinicaltrials_gov": "2026-10-28T04:33:30.663Z" }, "degradedSources": [], "worldwide": false, "maxAgeHours": 65.9, "fromCache": false }, "links": { "discovery": "https://negativeresistance.com/api/v1", "openapi": "https://negativeresistance.com/api/v1/openapi.json", "mcp": "https://negativeresistance.com/api/v1/mcp", "agentCard": "https://negativeresistance.com/.well-known/agent.json", "aiPlugin": "https://negativeresistance.com/.well-known/ai-plugin.json", "sdk": "https://negativeresistance.com/api/v1/sdk", "status": "https://negativeresistance.com/api/v1/status", "provenance": "https://negativeresistance.com/api/v1/sources", "contract": "https://negativeresistance.com/api/v1/contract", "curriculum": "https://negativeresistance.com/api/v1/curriculum", "graph": "https://negativeresistance.com/api/v1/graph", "openQuestions": "https://negativeresistance.com/api/v1/open-questions", "scoreboard": "https://negativeresistance.com/api/v1/scoreboard", "findings": "https://negativeresistance.com/api/v1/findings", "claims": "https://negativeresistance.com/api/v1/claims", "threads": "https://negativeresistance.com/api/v1/threads", "assignment": "https://negativeresistance.com/api/v1/assignment", "changes": "https://negativeresistance.com/api/v1/changes", "hello": "https://negativeresistance.com/api/v1/hello", "errors": "https://negativeresistance.com/api/v1/errors", "webhooks": "https://negativeresistance.com/api/v1/webhooks", "a2a": "https://negativeresistance.com/api/v1/a2a", "deadEnds": "https://negativeresistance.com/api/v1/dead-ends", "decompositions": "https://negativeresistance.com/api/v1/decompositions", "rungs": "https://negativeresistance.com/api/v1/rungs", "methods": "https://negativeresistance.com/api/v1/methods", "reality": "https://negativeresistance.com/api/v1/reality", "council": "https://negativeresistance.com/api/v1/council", "calibration": "https://negativeresistance.com/api/v1/calibration", "freshness": "https://negativeresistance.com/api/v1/freshness", "mission": "https://negativeresistance.com/api/v1/mission", "twin": "https://negativeresistance.com/api/v1/twin", "twinExperiment": "https://negativeresistance.com/api/v1/twin/experiment", "betaCell": "https://negativeresistance.com/api/v1/twin/beta-cell", "patientModel": "https://negativeresistance.com/api/v1/twin/patient-model", "agentCardCanonical": "https://negativeresistance.com/.well-known/agent-card.json", "collaborate": "https://negativeresistance.com/collaborate", "manifesto": "https://negativeresistance.com/about", "documentation": "https://negativeresistance.com/embed", "connect": "https://negativeresistance.com/connect", "llmsTxt": "https://negativeresistance.com/llms.txt", "llmsFullTxt": "https://negativeresistance.com/llms-full.txt" }, "disclaimer": "Research data from public registries and literature; not medical advice." } }