{ "data": { "asOf": "2026-10-30T22:27:22.995Z", "dedupMethod": "exact cross-registry identifier matching; probabilistic = review only", "byRegistry": { "clinicaltrials_gov": 1 }, "canonicalTrial": { "canonicalId": "NCT07437976", "title": "A Natural History of Genetic and Environmental Predictors of Pubertal Timing Among Youth With Obesity", "scientificTitle": "A Natural History of Genetic and Environmental Predictors of Pubertal Timing Among Youth With Obesity", "status": "not_yet_recruiting", "studyType": "observational", "phase": [], "conditions": [ "Obesity" ], "interventions": [ { "name": "Weight loss intervention", "type": "BEHAVIORAL", "description": "Pediatric Weight Management Clinic, which utilizes multiple, individualized strategies to effect weight loss (such as nutrition, behavioral therapy, exercise programs)" }, { "name": "No Weight loss intervention", "type": "BEHAVIORAL", "description": "No strategies for weight loss" } ], "sponsor": { "name": "National Institute of Environmental Health Sciences (NIEHS)", "type": "NIH" }, "locations": [ { "city": "Research Triangle Park", "country": "United States", "facility": "National Institute of Environmental Health Sciences Clinical Research Unit" } ], "outcomes": { "other": [], "primary": [ "To identify predictors of pubertal timing in 5-12-year-old children with obesity" ], "secondary": [ "To determine the effect of obesity on reproductive hormones and adrenarche." ] }, "eligibility": { "sex": "ALL", "criteria": "* INCLUSION CRITERIA:\n\nTo be eligible to participate in this study, an individual must meet all of the following criteria:\n\n1. Stated willingness to comply with all study procedures and availability for the duration of the study, including sharing medical records\n2. Male or female, aged 5 to 7 years at the screening visit\n3. Normal weight (defined as BMI \\> 5th percentile and \\<85th percentile for age and sex) or Obese weight (defined as BMI \\> 95th percentile for age and sex)\n4. Ability of parent or guardian to understand and willingness to sign a written informed consent document. And ability of the participant (child) to provide verbal assent and/or to sign a written assent document.\n\nEXCLUSION CRITERIA:\n\nAn individual who meets any of the following criteria will be excluded from participation in this study:\n\n1. Known diagnosis of syndromic/genetic form of obesity\n2. Current use of medications or supplements that affect reproductive hormones (e.g., estrogen, progesterone, testosterone, puberty blockers, regular use of lavender oil or tea tree oil)\n3. 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