{ "data": { "asOf": "2026-10-30T22:25:43.812Z", "dedupMethod": "exact cross-registry identifier matching; probabilistic = review only", "byRegistry": { "clinicaltrials_gov": 1 }, "canonicalTrial": { "canonicalId": "NCT07414810", "title": "Novel Point-of-care Sweat Chloride Testing Device for Monitoring CFTR Function", "scientificTitle": "Novel Point-of-care Sweat Chloride Testing Device for Monitoring CFTR Function", "status": "not_yet_recruiting", "studyType": "interventional", "phase": [], "conditions": [ "Cystic Fibrosis" ], "interventions": [ { "name": "micro Sweat Test Patch (mSTP)", "type": "DEVICE", "description": "A novel sweat test method, using a device that includes a microneedle pilocarpine patch and a microchannel with a sweat chloride sensor.\n\nµSTP sweat testing device that operates without electrical current, eliminating the risk of burns and the need for specialized equipment.\n\nLike the SOC method, the µSTP stimulates sweating with pilocarpine nitrate and measures sweat chloride concentration but differs from the current method by:\n\n1. Utilizing microneedles to painlessly and rapidly administer pilocarpine to the skin (without the complexities and risks of iontophoresis)\n2. Requiring only 0.5 µL of sweat to measure sweat chloride (instead of the 15 µL currently required)\n3. Wirelessly communicating the result to a tablet or other device\n4. Completing the POC measurement to provide immediate results without sending any samples to the laboratory." }, { "name": "Sweat Testing using SOC", "type": "DIAGNOSTIC_TEST", "description": "The study team will place two pilocarpine gel discs into the corresponding electrodes and place them on the participant's arm.\n\nThe SOC method takes 5 minutes to induce sweating. After sweat has been induced by the SOC method, a sweat collector will be placed on the location of the red electrode to collect the sweat. At the end of the sweat collection period, the sweat collection device will be removed, and the study visit will be completed. For newborns undergoing evaluation for CF, the study team will perform the µSTP method on their thigh instead of the forearm. Since newborns will undergo sweat testing for their clinical diagnosis, the study team will use the sweat data from SOC testing to minimize burden.\n\nThe sweat chloride concentration will be assessed by a laboratory chloridometer." } ], "sponsor": { "name": "Emory University", "type": "OTHER" }, "locations": [ { "city": "Atlanta", "country": "United States", "facility": "Adult Cystic Fibrosis Clinic" }, { "city": "Atlanta", "country": "United States", "facility": "Arthur M. Blank Hospital | Children's Healthcare of Atlanta" } ], "outcomes": { "other": [], "primary": [ "Sweat Chloride Concentration using the sweat test sensor", "Sweat Chloride Concentration by SOC" ], "secondary": [ "Visual Erythema Assessment Scale", "Pain Score" ] }, "eligibility": { "sex": "ALL", "criteria": "Inclusion Criteria:\n\n* Age 0-90 years old\n* Signed a written informed consent\n* Confirmed CF diagnosis via genetic test or elevated Immunoreactive Trypsinogen (IRT) level in newborn screen\n\nExclusion Criteria:\n\n* History of skin disorders (eczema, psoriasis, etc.) that could prevent sweat testing on the forearms", "maximumAge": "90 Years", "minimumAge": "2 Weeks", "healthyVolunteers": false }, "enrollment": { "type": "ESTIMATED", "count": 300 }, "startDate": "2026-11-01", "completionDate": "2027-07-01", "lastUpdated": "2026-10-27T00:00:00.000Z", "firstPosted": "2026-02-17T00:00:00.000Z", "resultsAvailable": false, "sourceRegistries": [ "clinicaltrials_gov" ], "sourceUrls": [ "https://clinicaltrials.gov/study/NCT07414810" ] }, "identifiers": [ { "idType": "nct", "idValue": "NCT07414810", "declaredBy": "clinicaltrials_gov" } ], "sourceRecords": [ { "registry": "clinicaltrials_gov", "registryName": "ClinicalTrials.gov", "license": "public-domain", "sourceId": "NCT07414810", "sourceUrl": "https://clinicaltrials.gov/study/NCT07414810", "sourceStatus": "NOT_YET_RECRUITING", "retrievedAt": "2026-10-28T04:32:26.115Z", "payloadSha256": "a525cd7c1fcb51c1fa7f8d007819849d768f591ac49b795d57122b0494f1b6a6", "piiRedacted": true } ], "citation": { "canonicalId": "NCT07414810", "sources": [ { "registry": "clinicaltrials_gov", "registryName": "ClinicalTrials.gov", "license": "public-domain", "sourceId": "NCT07414810", "verifyAt": "https://clinicaltrials.gov/study/NCT07414810", "retrievedAt": "2026-10-28T04:32:26.115Z", "payloadSha256": "a525cd7c1fcb51c1fa7f8d007819849d768f591ac49b795d57122b0494f1b6a6", "text": "ClinicalTrials.gov, record NCT07414810 (https://clinicaltrials.gov/study/NCT07414810), retrieved 2026-10-28, licence: public-domain." } ], "crossRegistry": false, "dedupMethod": "exact cross-registry identifier matching; probabilistic = review only", "text": "Trial NCT07414810, registered in ClinicalTrials.gov, retrieved 2026-10-28. Verify at the source URLs listed; each retrieval is checksummed.", "note": "Only one registry is known to hold this trial. Absence from the others is not evidence it was not registered there." }, "provenanceNote": "Personal contact fields (names, emails, phone numbers, addresses) are stripped from every stored payload. No participant-level data is collected or served." }, "_meta": { "api": "The Last Economy Wire: World Trials API", "version": "1.0", "schemaVersion": "1", "correlationId": "req_6N7Fo6jQFSJR", "generatedAt": "2026-10-30T22:25:43.812Z", "documentation": "https://negativeresistance.com/embed", "license": "Free for any use. Attribution appreciated.", "degraded": false, "provenance": { "sources": [ "clinicaltrials_gov" ], "attribution": { "clinicaltrials_gov": "ClinicalTrials.gov: licence: public-domain, https://clinicaltrials.gov/data-api/api-docs" }, "dedupMethod": "exact cross-registry identifier matching; probabilistic = review only", "limitations": [], "provenanceEndpoint": "/api/v1/sources" }, "freshness": { "newestEvidenceAt": null, "lastSyncedAt": { "clinicaltrials_gov": "2026-10-28T04:33:30.663Z" }, "degradedSources": [], "worldwide": false, "maxAgeHours": 65.9, "fromCache": false }, "links": { "discovery": "https://negativeresistance.com/api/v1", "openapi": "https://negativeresistance.com/api/v1/openapi.json", "mcp": "https://negativeresistance.com/api/v1/mcp", "agentCard": "https://negativeresistance.com/.well-known/agent.json", "aiPlugin": "https://negativeresistance.com/.well-known/ai-plugin.json", "sdk": "https://negativeresistance.com/api/v1/sdk", "status": "https://negativeresistance.com/api/v1/status", "provenance": "https://negativeresistance.com/api/v1/sources", "contract": "https://negativeresistance.com/api/v1/contract", "curriculum": "https://negativeresistance.com/api/v1/curriculum", "graph": "https://negativeresistance.com/api/v1/graph", "openQuestions": "https://negativeresistance.com/api/v1/open-questions", "scoreboard": "https://negativeresistance.com/api/v1/scoreboard", "findings": "https://negativeresistance.com/api/v1/findings", "claims": "https://negativeresistance.com/api/v1/claims", "threads": "https://negativeresistance.com/api/v1/threads", "assignment": "https://negativeresistance.com/api/v1/assignment", "changes": "https://negativeresistance.com/api/v1/changes", "hello": "https://negativeresistance.com/api/v1/hello", "errors": "https://negativeresistance.com/api/v1/errors", "webhooks": "https://negativeresistance.com/api/v1/webhooks", "a2a": "https://negativeresistance.com/api/v1/a2a", "deadEnds": "https://negativeresistance.com/api/v1/dead-ends", "decompositions": "https://negativeresistance.com/api/v1/decompositions", "rungs": "https://negativeresistance.com/api/v1/rungs", "methods": "https://negativeresistance.com/api/v1/methods", "reality": "https://negativeresistance.com/api/v1/reality", "council": "https://negativeresistance.com/api/v1/council", "calibration": "https://negativeresistance.com/api/v1/calibration", "freshness": "https://negativeresistance.com/api/v1/freshness", "mission": "https://negativeresistance.com/api/v1/mission", "twin": "https://negativeresistance.com/api/v1/twin", "twinExperiment": "https://negativeresistance.com/api/v1/twin/experiment", "betaCell": "https://negativeresistance.com/api/v1/twin/beta-cell", "patientModel": "https://negativeresistance.com/api/v1/twin/patient-model", "agentCardCanonical": "https://negativeresistance.com/.well-known/agent-card.json", "collaborate": "https://negativeresistance.com/collaborate", "manifesto": "https://negativeresistance.com/about", "documentation": "https://negativeresistance.com/embed", "connect": "https://negativeresistance.com/connect", "llmsTxt": "https://negativeresistance.com/llms.txt", "llmsFullTxt": "https://negativeresistance.com/llms-full.txt" }, "disclaimer": "Research data from public registries and literature; not medical advice." } }