{
  "data": {
    "asOf": "2026-10-30T22:25:45.343Z",
    "dedupMethod": "exact cross-registry identifier matching; probabilistic = review only",
    "byRegistry": {
      "clinicaltrials_gov": 1
    },
    "canonicalTrial": {
      "canonicalId": "NCT07192952",
      "title": "A Study to Learn More About How Safe Finerenone is, When it is Taken for a Longer Time With Standard Treatment, in Children and Young Adults With Heart Failure and Left Ventricular Systolic Dysfunction",
      "scientificTitle": "A Phase 3, Single-arm, Open-label Extension Study to Evaluate the Safety of Finerenone in Addition to Standard of Care, in Pediatric Heart Failure Patients, From Birth to 18 Years of Age, With Left Ventricular Systolic Dysfunction (LVSD)",
      "status": "recruiting",
      "studyType": "interventional",
      "phase": [
        "PHASE3"
      ],
      "conditions": [
        "Left Ventricular Systolic Dysfunction",
        "Heart Failure (Pediatric)"
      ],
      "interventions": [
        {
          "name": "Finerenone (Kerendia, BAY94-8862)",
          "type": "DRUG",
          "description": "Finerenone in different doses, treatment duration will be 270±7 days."
        }
      ],
      "sponsor": {
        "name": "Bayer",
        "type": "INDUSTRY"
      },
      "locations": [
        {
          "city": "Aurora",
          "country": "United States",
          "facility": "Children's Hospital Colorado - Anschutz Medical Campus - Cardiology"
        },
        {
          "city": "Wilmington",
          "country": "United States",
          "facility": "Nemours Children's Hospital - Delaware - Cardiology"
        },
        {
          "city": "Gainesville",
          "country": "United States",
          "facility": "UF Health Shands Hospital - Pediatric Cardiology"
        },
        {
          "city": "Hollywood",
          "country": "United States",
          "facility": "Joe Dimaggio Children's Hospital - Cardiology"
        },
        {
          "city": "Atlanta",
          "country": "United States",
          "facility": "Emory University Hospital - Children's Healthcare of Atlanta Cardiology - Atlanta"
        },
        {
          "city": "Indianapolis",
          "country": "United States",
          "facility": "Riley Hospital For Children - Cardiology"
        },
        {
          "city": "Boston",
          "country": "United States",
          "facility": "Boston Children's Hospital - Main Campus - Cardiology"
        },
        {
          "city": "Ann Arbor",
          "country": "United States",
          "facility": "C.S. Mott Children's Hospital - Cardiology"
        },
        {
          "city": "Kansas City",
          "country": "United States",
          "facility": "Children's Mercy Hospital Kansas City - Cardiology"
        },
        {
          "city": "St Louis",
          "country": "United States",
          "facility": "Washington University - St. Louis Children's Hospital - Cardiology"
        },
        {
          "city": "New York",
          "country": "United States",
          "facility": "Icahn School of Medicine at Mount Sinai - Pediatric Cardiology"
        },
        {
          "city": "New York",
          "country": "United States",
          "facility": "Columbia University Irving Medical Center - Pediatric Cardiology"
        },
        {
          "city": "The Bronx",
          "country": "United States",
          "facility": "The Children's Hospital at Montefiore - Cardiology"
        },
        {
          "city": "Cincinnati",
          "country": "United States",
          "facility": "Cincinnati Children's Hospital Medical Center | Division of Nephrology and Hypertension"
        },
        {
          "city": "Cleveland",
          "country": "United States",
          "facility": "Cleveland Clinic Children's"
        },
        {
          "city": "Columbus",
          "country": "United States",
          "facility": "Nationwide Children's Hospital - Cardiology"
        },
        {
          "city": "Philadelphia",
          "country": "United States",
          "facility": "Children's Hospital of Philadelphia - Cardiology"
        },
        {
          "city": "Pittsburgh",
          "country": "United States",
          "facility": "UPMC Children's Hospital of Pittsburgh - Cardiology"
        },
        {
          "city": "North Charleston",
          "country": "United States",
          "facility": "MUSC Shawn Jenkins Children's Hospital - Cardiology"
        },
        {
          "city": "Dallas",
          "country": "United States",
          "facility": "Children's Medical Center Dallas - Cardiology"
        },
        {
          "city": "Houston",
          "country": "United States",
          "facility": "Texas Children's Hospital - Cardiology"
        },
        {
          "city": "Salt Lake City",
          "country": "United States",
          "facility": "Eccles Primary Children's Outpatient Services - Cardiology"
        },
        {
          "city": "La Plata",
          "country": "Argentina",
          "facility": "Hospital de Niños Sor María Ludovica"
        },
        {
          "city": "Zárate",
          "country": "Argentina",
          "facility": "Instituto De Investigaciones Clinicas Zarate | Zarate, Argentina"
        },
        {
          "city": "Buenos Aires",
          "country": "Argentina",
          "facility": "Hospital General de Ninos Ricardo Gutierrez | Cardiology Department"
        },
        {
          "city": "Rosario",
          "country": "Argentina",
          "facility": "Consultorios Integrados Rosario | Instituto Medico de la Fundacion de Estudios Clinicos"
        },
        {
          "city": "Buenos Aires",
          "country": "Argentina",
          "facility": "Hospital Italiano de Buenos Aires"
        },
        {
          "city": "Buenos Aires",
          "country": "Argentina",
          "facility": "Hospital de Pediatría Juan P. Garrahan"
        },
        {
          "city": "Buenos Aires",
          "country": "Argentina",
          "facility": "Hospital General de Ninos Pedro de Elizalde | Nephrology Department"
        },
        {
          "city": "Buenos Aires",
          "country": "Argentina",
          "facility": "Consultorios Médicos Dr. Doreski"
        },
        {
          "city": "Córdoba",
          "country": "Argentina",
          "facility": "Sanatorio de la Cañada"
        },
        {
          "city": "Salta",
          "country": "Argentina",
          "facility": "Centro Cardiovascular Salta (Torzav SRL)"
        },
        {
          "city": "Vienna",
          "country": "Austria",
          "facility": "Medizinische Universität Wien - Klinik für Kinder- und Jugendheilkunde, Abteilung für Pädiatrische Kardiologie"
        },
        {
          "city": "Linz",
          "country": "Austria",
          "facility": "Kepler Universitätsklinikum GmbH - Klinik für Kinderkardiologie"
        },
        {
          "city": "Edegem",
          "country": "Belgium",
          "facility": "UZ Antwerpen - Pediatric Cardiology"
        },
        {
          "city": "Brussels",
          "country": "Belgium",
          "facility": "Cliniques Universitaires St-Luc (UCL) - Pediatric Cardiology"
        },
        {
          "city": "Ghent",
          "country": "Belgium",
          "facility": "UZ Gent - Pediatric Cardiology"
        },
        {
          "city": "Leuven",
          "country": "Belgium",
          "facility": "UZ Leuven - Pediatric Cardiology"
        },
        {
          "city": "Liège",
          "country": "Belgium",
          "facility": "CHC MontLegia - Pediatric Cardiology"
        },
        {
          "city": "Salvador",
          "country": "Brazil",
          "facility": "Liga Alvaro Bahia Contra a Mortalidade Infantil - Hospital Martagão Gesteira"
        },
        {
          "city": "Uberlândia",
          "country": "Brazil",
          "facility": "Hospital de Clínicas da Universidade Federal de Uberlândia Empresa Brasileira de Serviços Hospitalares - EBSERH"
        },
        {
          "city": "Curitiba",
          "country": "Brazil",
          "facility": "Hospital Pequeno Principe"
        },
        {
          "city": "Porto Alegre",
          "country": "Brazil",
          "facility": "Centro de Pesquisa Clinica e Populacional Hospitalize"
        },
        {
          "city": "Marília",
          "country": "Brazil",
          "facility": "Fundação Universidade de Caxias do Sul"
        },
        {
          "city": "São Paulo",
          "country": "Brazil",
          "facility": "Hospital Infantil Sabará - Instituto PENSI - Pesquisa e Ensino em Saúde Infantil"
        },
        {
          "city": "São Paulo",
          "country": "Brazil",
          "facility": "Instituto Dante Pazzanese de Cardiologia | Divisao de Pesquisa"
        },
        {
          "city": "São Paulo",
          "country": "Brazil",
          "facility": "Campinas Clinical Research Institute (IPECC) | Campinas, Brazil"
        },
        {
          "city": "São Paulo",
          "country": "Brazil",
          "facility": "Santa Casa de Misericórdia de Belo Horizonte"
        },
        {
          "city": "São Paulo",
          "country": "Brazil",
          "facility": "InCor HCFMUSP"
        },
        {
          "city": "Plovdiv",
          "country": "Bulgaria",
          "facility": "University Multiprofile Hospital for Active Treatment 'Sveti Georgi' EAD, Plovdiv Pediatric Clinic"
        },
        {
          "city": "Sofia",
          "country": "Bulgaria",
          "facility": "National Heart Hospital (NHH) - Dept. Pediatric Cardiology"
        },
        {
          "city": "Sofia",
          "country": "Bulgaria",
          "facility": "Medical Center Nora- Heart ЕOOD Child Cardiology"
        },
        {
          "city": "Sofia",
          "country": "Bulgaria",
          "facility": "University Multiprofile Hospital for Active Treatment 'Sveta Ekaterina' EAD, Sofia"
        },
        {
          "city": "Edmonton",
          "country": "Canada",
          "facility": "Stollery Children's Hospital | Cardiology"
        },
        {
          "city": "Vancouver",
          "country": "Canada",
          "facility": "BC Children's Hospital | Children's Heart Centre"
        },
        {
          "city": "London",
          "country": "Canada",
          "facility": "Children's Hospital | Cardiology"
        },
        {
          "city": "Toronto",
          "country": "Canada",
          "facility": "The Hospital for Sick Children (SickKids) | Cardiology"
        },
        {
          "city": "Montreal",
          "country": "Canada",
          "facility": "Centre hospitalier universitaire Sainte-Justine | Cardiology"
        },
        {
          "city": "Saskatoon",
          "country": "Canada",
          "facility": "Royal University Hospital | Cardiology"
        },
        {
          "city": "Prague",
          "country": "Czechia",
          "facility": "Fakultní nemocnice Motol a Homolka, Pracoviště MOTOL - Dětské kardiocentrum 2. LF UK a FN Motol"
        },
        {
          "city": "Brno",
          "country": "Czechia",
          "facility": "Fakultní nemocnice Brno, Dětská nemocnice - Pediatrická klinika"
        },
        {
          "city": "Helsinki",
          "country": "Finland",
          "facility": "HUS-Yhtymä, Helsingin yliopistollinen sairaala (HUS) - Uusi lastensairaala, kardiologia"
        },
        {
          "city": "Tübingen",
          "country": "Germany",
          "facility": "Universitätsklinikum Tübingen, Kinderheilkunde II - Kinderkardiologie, Pulmologie, Intensivmedizin"
        },
        {
          "city": "Giessen",
          "country": "Germany",
          "facility": "Universitaetsklinikum Giessen und Marburg GmbH - Kinderherzzentrum und Zentrum für angeborene Herzfehler"
        },
        {
          "city": "Cologne",
          "country": "Germany",
          "facility": "Universitätsklinikum Köln - Kinderkardiologie"
        },
        {
          "city": "Kallithea",
          "country": "Greece",
          "facility": "Onassis Cardiac Surgery Center, Department of Pediatric Cardiology and Adult Congenital Heart Disease"
        },
        {
          "city": "Athens",
          "country": "Greece",
          "facility": "Athens General Children's Hospital Panagioti And Aglaia Kyriakou -2nd University Department of Pediatrics"
        },
        {
          "city": "Athens",
          "country": "Greece",
          "facility": "Athens General Children's Hospital Panagioti And Aglaia Kyriakou, Cardiology Department"
        },
        {
          "city": "Athens",
          "country": "Greece",
          "facility": "Nosokomeio Paidon I Agia Sofia, Cardiology Department"
        },
        {
          "city": "Budapest",
          "country": "Hungary",
          "facility": "Gottsegen Gyorgy Orszagos Kardiovaszkularis Intezet - Gyermeksziv Kozpont"
        },
        {
          "city": "Holon",
          "country": "Israel",
          "facility": "Edith Wolfson Medical Center (EWMC)"
        },
        {
          "city": "Tel HaShomer",
          "country": "Israel",
          "facility": "Chaim Sheba Medical Center"
        },
        {
          "city": "Jerusalem",
          "country": "Israel",
          "facility": "Shaare Zedek Medical Center"
        },
        {
          "city": "Tel Aviv",
          "country": "Israel",
          "facility": "Dana-Dwek Children's Hospital"
        },
        {
          "city": "Rome",
          "country": "Italy",
          "facility": "Ospedale Pediatrico Bambino Gesù - Unità Terapie Cardiovascolari Avanzate"
        },
        {
          "city": "Genoa",
          "country": "Italy",
          "facility": "IRCCS Istituto Giannina Gaslini - Cardiologia"
        },
        {
          "city": "Turin",
          "country": "Italy",
          "facility": "A.O.U. Città della Salute e della Scienza di Torino_Regina Margherita - Cadiologia pediatrica"
        },
        {
          "city": "Padova",
          "country": "Italy",
          "facility": "Azienda Ospedale-Università di Padova - UOC Cardiologia Pediatrica"
        },
        {
          "city": "Bergamo",
          "country": "Italy",
          "facility": "Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII - Cardiologia 2 - Cardiopatie Congenite del bambino e dell'adulto"
        },
        {
          "city": "Bologna",
          "country": "Italy",
          "facility": "Azienda Ospedaliero-Universitaria di Bologna IRCCS Policlinico Sant'Orsola-Cardiologia pediatrica ed dell'età evolutiva"
        },
        {
          "city": "Milan",
          "country": "Italy",
          "facility": "ASST Grande Ospedale Metropolitano Niguarda - Struttura semplice dipartimentale cardiologia pediatrica"
        },
        {
          "city": "Naples",
          "country": "Italy",
          "facility": "Azienda Ospedaliera Dei Colli_Monaldi - Malattie Rare e Genetiche Cardiovascolari"
        },
        {
          "city": "Guadalajara",
          "country": "Mexico",
          "facility": "Centro de Investigación Clínica Médica y Farmacológica S.A de C.V"
        },
        {
          "city": "México D.F.",
          "country": "Mexico",
          "facility": "Hospital Infantil de México \"Dr. Federico Gómez\""
        },
        {
          "city": "Tlalpan",
          "country": "Mexico",
          "facility": "Instituto Nacional de Cardiología \"Ignacio Chávez\""
        },
        {
          "city": "Monterrey",
          "country": "Mexico",
          "facility": "Hospital Universitario \"Dr. Jose Eleuterio Gonzalez\"-Pediatria"
        },
        {
          "city": "Huixquilucan",
          "country": "Mexico",
          "facility": "Invecordis Sc."
        },
        {
          "city": "Ciudad Madero",
          "country": "Mexico",
          "facility": "Centro de Estudios de Investigacion Metabolicos y Cardiovasculares"
        },
        {
          "city": "Querétaro",
          "country": "Mexico",
          "facility": "Centro de Estudios Clínicos de Querétaro S.C."
        },
        {
          "city": "San Luis Potosí City",
          "country": "Mexico",
          "facility": "Centro de Atención e Investigación Cardiovascular del Potosí S.C."
        },
        {
          "city": "Wroclaw",
          "country": "Poland",
          "facility": "Uniwersytecki Szpital Kliniczny Im. Jana Mikulicza-Radeckiego We Wroclawiu"
        },
        {
          "city": "Warsaw",
          "country": "Poland",
          "facility": "Pomnik Centrum Zdrowia Dziecka - Klinika Kardiologii"
        },
        {
          "city": "Gdansk",
          "country": "Poland",
          "facility": "Uniwersyteckie Centrum Kliniczne - Klinika Kardiologii Dziecięcej i Wad Wrodzonych Serca"
        },
        {
          "city": "Katowice",
          "country": "Poland",
          "facility": "Górnośląskie Centrum Zdrowia Dziecka im. św. Jana Pawła II SPSK Nr 6 Śląskiego UM w Katowicach - Oddział Kardiologii Dziecięcej"
        },
        {
          "city": "Lodz",
          "country": "Poland",
          "facility": "Instytut Centrum Zdrowia Matki Polki w Łodzi - Klinika Kardiologii"
        },
        {
          "city": "Coimbra",
          "country": "Portugal",
          "facility": "Unidade Local de Saúde de Coimbra, E.P.E. - Hospital Pediátrico - Serviço de Cardiologia Pediátrica"
        },
        {
          "city": "Carnaxide",
          "country": "Portugal",
          "facility": "Hospital de Santa Cruz | Pediatric Cardiology Department"
        },
        {
          "city": "Lisbon",
          "country": "Portugal",
          "facility": "Hospital Santa Marta | Pediatric Cardiology Department"
        },
        {
          "city": "Porto",
          "country": "Portugal",
          "facility": "Unidade Local de Saúde de Santo António, E.P.E. - Centro Materno Infantil do Norte - Serviço de Cardiologia Pediátrica"
        },
        {
          "city": "Porto",
          "country": "Portugal",
          "facility": "Unidade Local de Saúde de São João E.P.E. - Hospital São João - Serviço de Pediatria"
        },
        {
          "city": "Yangsan",
          "country": "South Korea",
          "facility": "Pusan National University Children's Hospital | Pediatric Cardiology"
        },
        {
          "city": "Seoul",
          "country": "South Korea",
          "facility": "Seoul National University Hospital | Pediatric Cardiology"
        },
        {
          "city": "Seoul",
          "country": "South Korea",
          "facility": "Severance Hospital | Pediatric Cardiology"
        },
        {
          "city": "Seoul",
          "country": "South Korea",
          "facility": "Samsung Medical Center | Pediatric Cardiology"
        },
        {
          "city": "Madrid",
          "country": "Spain",
          "facility": "Hospital Universitario 12 De Octubre | Cardiologia pediatrica"
        },
        {
          "city": "Madrid",
          "country": "Spain",
          "facility": "Hospital Universitario La Paz | Cardiologia pediatrica"
        },
        {
          "city": "Barcelona",
          "country": "Spain",
          "facility": "Hospital Sant Joan De Deu Barcelona | Cardiologia pediatrica"
        },
        {
          "city": "Barcelona",
          "country": "Spain",
          "facility": "Hospital Universitari Vall D Hebron | Cardiologia pediatrica"
        },
        {
          "city": "Córdoba",
          "country": "Spain",
          "facility": "Hospital Universitario Reina Sofia | Cardiologia pediatrica"
        },
        {
          "city": "Madrid",
          "country": "Spain",
          "facility": "Hospital Universitario Ramon Y Cajal | Cardiologia pediatrica"
        },
        {
          "city": "Málaga",
          "country": "Spain",
          "facility": "Hospital Universitario Regional De Malaga | Cardiologia pediatrica"
        },
        {
          "city": "Seville",
          "country": "Spain",
          "facility": "Hospital Universitario Virgen Del Rocio S.L. | Cardiologia pediatrica"
        },
        {
          "city": "Lund",
          "country": "Sweden",
          "facility": "Skånes Universitetssjukhus - Lund - Barnhjärtcentrum"
        },
        {
          "city": "Guishan",
          "country": "Taiwan",
          "facility": "Chang Gung Memorial Hospital (CGMH) - Kaohsiung Branch"
        },
        {
          "city": "Kaohsiung City",
          "country": "Taiwan",
          "facility": "Kaohsiung Veterans General Hospital"
        },
        {
          "city": "Taichung",
          "country": "Taiwan",
          "facility": "Taichung Veterans General Hospital"
        },
        {
          "city": "Tainan",
          "country": "Taiwan",
          "facility": "National Cheng Kung University Hospital"
        },
        {
          "city": "Taipei",
          "country": "Taiwan",
          "facility": "National Taiwan University Hospital"
        },
        {
          "city": "Taipei",
          "country": "Taiwan",
          "facility": "MacKay Children's hospital"
        },
        {
          "city": "Bilkent Ankara",
          "country": "Turkey (Türkiye)",
          "facility": "Ankara Bilkent Sehir Hastanesi"
        },
        {
          "city": "Adana",
          "country": "Turkey (Türkiye)",
          "facility": "Cukurova Universitesi Tip Fakultesi Hastanesi"
        },
        {
          "city": "Ankara",
          "country": "Turkey (Türkiye)",
          "facility": "Hacettepe Universitesi Tip Fakultesi"
        },
        {
          "city": "Istanbul",
          "country": "Turkey (Türkiye)",
          "facility": "Istanbul Mehmet Akif Ersoy Gogus Kalp Damar Cerrahisi E.A.H."
        },
        {
          "city": "Istanbul",
          "country": "Turkey (Türkiye)",
          "facility": "Marmara Uni. Tip Fak. Pendik EAH Kardiyoloji"
        },
        {
          "city": "Izmir",
          "country": "Turkey (Türkiye)",
          "facility": "İzmir Dr. Behcet Uz Cocuk Hastaliklari Hast"
        },
        {
          "city": "Leicester",
          "country": "United Kingdom",
          "facility": "Leicester Children's Hospital | Children's Research Facility"
        },
        {
          "city": "Liverpool",
          "country": "United Kingdom",
          "facility": "Alder Hey Children's Hospital | Clinical Research Facility"
        },
        {
          "city": "Belfast",
          "country": "United Kingdom",
          "facility": "Royal Belfast Hospital for Sick Children | Paediatric Cardiology"
        },
        {
          "city": "Glasgow",
          "country": "United Kingdom",
          "facility": "Royal Hospital for Children | Glasgow Clinical Research Facility"
        },
        {
          "city": "Newcastle upon Tyne",
          "country": "United Kingdom",
          "facility": "Freeman Hospital | Children's Heart Unit"
        },
        {
          "city": "Leeds",
          "country": "United Kingdom",
          "facility": "Leeds Children's Hospital | Children's Research Facility"
        },
        {
          "city": "Bristol",
          "country": "United Kingdom",
          "facility": "Bristol Royal Hospital for Children | Clinical Research Facility"
        }
      ],
      "outcomes": {
        "other": [],
        "primary": [
          "Number of participants with treatment-emergent adverse events (TEAEs)",
          "Change in serum potassium levels",
          "Change in systolic blood pressure (SBP)",
          "Change in estimated glomerular filtration rate (eGFR)"
        ],
        "secondary": [
          "Change in NT-proBNP levels",
          "Change in left ventricular systolic function",
          "Maximum observed finerenone concentration in plasma after multiple doses (Cmax, md)",
          "Area under the curve for finerenone concentration in plasma after multiple doses (AUCτ,md)",
          "Taste and Texture Questionnaire of the pediatric formulation"
        ]
      },
      "eligibility": {
        "sex": "ALL",
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