{
  "data": {
    "asOf": "2026-10-30T22:26:31.161Z",
    "dedupMethod": "exact cross-registry identifier matching; probabilistic = review only",
    "byRegistry": {
      "clinicaltrials_gov": 1
    },
    "canonicalTrial": {
      "canonicalId": "NCT07112924",
      "title": "CCM OPEN HF Registry",
      "scientificTitle": "CCM Technologies OPEN HF Registry: Observational Patient EvaluatioN of CCM® Therapy for Heart Failure",
      "status": "recruiting",
      "studyType": "observational",
      "phase": [],
      "conditions": [
        "Heart Failure"
      ],
      "interventions": [],
      "sponsor": {
        "name": "Impulse Dynamics",
        "type": "INDUSTRY"
      },
      "locations": [
        {
          "city": "Mesa",
          "country": "United States",
          "facility": "Cardiovascular Associates of Mesa"
        },
        {
          "city": "Phoenix",
          "country": "United States",
          "facility": "University of Arizona and Banner University Medical Center Phoenix"
        },
        {
          "city": "Phoenix",
          "country": "United States",
          "facility": "HonorHealth Research Institute"
        },
        {
          "city": "Surprise",
          "country": "United States",
          "facility": "Peak Heart and Vascular"
        },
        {
          "city": "Orlando",
          "country": "United States",
          "facility": "AdventHealth Orlando"
        },
        {
          "city": "Tampa",
          "country": "United States",
          "facility": "AdventHealth Tampa"
        },
        {
          "city": "Kansas City",
          "country": "United States",
          "facility": "University of Kansas Medical Center"
        },
        {
          "city": "Boston",
          "country": "United States",
          "facility": "Massachusetts General Hospital"
        },
        {
          "city": "Ann Arbor",
          "country": "United States",
          "facility": "University of Michigan"
        },
        {
          "city": "Novi",
          "country": "United States",
          "facility": "Henry Ford Providence Hospital"
        },
        {
          "city": "Ypsilanti",
          "country": "United States",
          "facility": "Trinity Ann Arbor d/b/a Michigan Heart Ann Arbor"
        },
        {
          "city": "Minneapolis",
          "country": "United States",
          "facility": "Minneapolis Heart Institute Research Foundation"
        },
        {
          "city": "Kansas City",
          "country": "United States",
          "facility": "Saint Luke's Hospital Mid America Heart Institute"
        },
        {
          "city": "Kansas City",
          "country": "United States",
          "facility": "Saint Luke's Hospital of Kansas City"
        },
        {
          "city": "Londonderry",
          "country": "United States",
          "facility": "Cardiovascular Specialists of New England Research Foundation"
        },
        {
          "city": "Browns Mills",
          "country": "United States",
          "facility": "Deborah Heart and Lung Center"
        },
        {
          "city": "Hackensack",
          "country": "United States",
          "facility": "Hackensack University Medical Center"
        },
        {
          "city": "Haddon Heights",
          "country": "United States",
          "facility": "Heart House"
        },
        {
          "city": "Newark",
          "country": "United States",
          "facility": "Rutgers New Jersey Medical School & University Hospital"
        },
        {
          "city": "Oklahoma City",
          "country": "United States",
          "facility": "Oklahoma Heart Hospital Research Foundation"
        },
        {
          "city": "Portland",
          "country": "United States",
          "facility": "Providence St. Vincent Medical Center"
        },
        {
          "city": "Portland",
          "country": "United States",
          "facility": "Legacy Medical Group Cardiology"
        },
        {
          "city": "West Reading",
          "country": "United States",
          "facility": "Reading Hospital"
        },
        {
          "city": "Germantown",
          "country": "United States",
          "facility": "The Stern Cardiovascular Foundation, Inc"
        },
        {
          "city": "El Paso",
          "country": "United States",
          "facility": "David Turbay, MD"
        },
        {
          "city": "El Paso",
          "country": "United States",
          "facility": "Texan Cardiovascular Institute"
        },
        {
          "city": "Tyler",
          "country": "United States",
          "facility": "CHRISTUS Trinity Mother Frances Health System"
        },
        {
          "city": "Lynchburg",
          "country": "United States",
          "facility": "Centra Health, Inc. dba Stroobants Cardiovascular Center"
        },
        {
          "city": "Vancouver",
          "country": "United States",
          "facility": "PeaceHealth Southwest Medical Center"
        },
        {
          "city": "Milwaukee",
          "country": "United States",
          "facility": "Advocate Aurora Health-St. Lukes"
        }
      ],
      "outcomes": {
        "other": [],
        "primary": [
          "Assess CCM's effect on the rate and length of stay of heart failure (HF) hospitalizations",
          "Demonstrate the long-term safety of CCM therapy in a real-world setting, by assessing the rate of device- or procedure-related complications."
        ],
        "secondary": [
          "Assess CCM's effect on clinical outcomes",
          "Assess CCM's effect on mortality (all-cause, cardiovascular, and heart failure related)",
          "Assess CCM's effect on healthy days at home (HDAH)",
          "Assess CCM's effect on functional capacity",
          "Kansas City Cardiomyopathy Questionnaire (KCCQ)",
          "Assess CCM's effect cardiovascular reverse remodeling",
          "Assess CCM's effect QRS duration",
          "Assess CCM's systemic effects",
          "Assess long-term CCM device-related adverse events and lead related events",
          "Assess the dose response of CCM therapy",
          "Evaluate subject battery charging compliance",
          "Assess the effect of ancillary equipment on clinical outcomes",
          "Assess CCM clinical outcomes by subject sub-groups"
        ]
      },
      "eligibility": {
        "sex": "ALL",
        "criteria": "Inclusion Criteria:\n\n* Patients who have /will be implanted with Impulse Dynamics CCM technologies (e.g. CCM or CCM-D when available) as determined by investigators\n* Willing and able to provide informed consent, including for use of data for research purposes (e.g. publication, sub-studies/sub-analyses)\n\nExclusion Criteria:\n\n* Noncompliant patients (e.g. for follow-up visits, medication, etc.) as determined by investigators.\n* Subjects with a mechanical tricuspid valve",
        "minimumAge": "18 Years",
        "healthyVolunteers": false
      },
      "enrollment": {
        "type": "ESTIMATED",
        "count": 5500
      },
      "startDate": "2025-11-01",
      "completionDate": "2036-08-01",
      "lastUpdated": "2026-10-27T00:00:00.000Z",
      "firstPosted": "2025-08-08T00:00:00.000Z",
      "resultsAvailable": false,
      "sourceRegistries": [
        "clinicaltrials_gov"
      ],
      "sourceUrls": [
        "https://clinicaltrials.gov/study/NCT07112924"
      ]
    },
    "identifiers": [
      {
        "idType": "nct",
        "idValue": "NCT07112924",
        "declaredBy": "clinicaltrials_gov"
      }
    ],
    "sourceRecords": [
      {
        "registry": "clinicaltrials_gov",
        "registryName": "ClinicalTrials.gov",
        "license": "public-domain",
        "sourceId": "NCT07112924",
        "sourceUrl": "https://clinicaltrials.gov/study/NCT07112924",
        "sourceStatus": "RECRUITING",
        "retrievedAt": "2026-10-28T04:32:12.785Z",
        "payloadSha256": "84c4229aa2f6995f6881a5a86eb7832a92b99b2a2552c0bb46382882e765f1d4",
        "piiRedacted": true
      }
    ],
    "citation": {
      "canonicalId": "NCT07112924",
      "sources": [
        {
          "registry": "clinicaltrials_gov",
          "registryName": "ClinicalTrials.gov",
          "license": "public-domain",
          "sourceId": "NCT07112924",
          "verifyAt": "https://clinicaltrials.gov/study/NCT07112924",
          "retrievedAt": "2026-10-28T04:32:12.785Z",
          "payloadSha256": "84c4229aa2f6995f6881a5a86eb7832a92b99b2a2552c0bb46382882e765f1d4",
          "text": "ClinicalTrials.gov, record NCT07112924 (https://clinicaltrials.gov/study/NCT07112924), retrieved 2026-10-28, licence: public-domain."
        }
      ],
      "crossRegistry": false,
      "dedupMethod": "exact cross-registry identifier matching; probabilistic = review only",
      "text": "Trial NCT07112924, registered in ClinicalTrials.gov, retrieved 2026-10-28. Verify at the source URLs listed; each retrieval is checksummed.",
      "note": "Only one registry is known to hold this trial. Absence from the others is not evidence it was not registered there."
    },
    "provenanceNote": "Personal contact fields (names, emails, phone numbers, addresses) are stripped from every stored payload. No participant-level data is collected or served."
  },
  "_meta": {
    "api": "The Last Economy Wire: World Trials API",
    "version": "1.0",
    "schemaVersion": "1",
    "correlationId": "req_WEXFJO4tVbe4",
    "generatedAt": "2026-10-30T22:26:31.161Z",
    "documentation": "https://negativeresistance.com/embed",
    "license": "Free for any use. Attribution appreciated.",
    "degraded": false,
    "provenance": {
      "sources": [
        "clinicaltrials_gov"
      ],
      "attribution": {
        "clinicaltrials_gov": "ClinicalTrials.gov: licence: public-domain, https://clinicaltrials.gov/data-api/api-docs"
      },
      "dedupMethod": "exact cross-registry identifier matching; probabilistic = review only",
      "limitations": [],
      "provenanceEndpoint": "/api/v1/sources"
    },
    "freshness": {
      "newestEvidenceAt": null,
      "lastSyncedAt": {
        "clinicaltrials_gov": "2026-10-28T04:33:30.663Z"
      },
      "degradedSources": [],
      "worldwide": false,
      "maxAgeHours": 65.9,
      "fromCache": false
    },
    "links": {
      "discovery": "https://negativeresistance.com/api/v1",
      "openapi": "https://negativeresistance.com/api/v1/openapi.json",
      "mcp": "https://negativeresistance.com/api/v1/mcp",
      "agentCard": "https://negativeresistance.com/.well-known/agent.json",
      "aiPlugin": "https://negativeresistance.com/.well-known/ai-plugin.json",
      "sdk": "https://negativeresistance.com/api/v1/sdk",
      "status": "https://negativeresistance.com/api/v1/status",
      "provenance": "https://negativeresistance.com/api/v1/sources",
      "contract": "https://negativeresistance.com/api/v1/contract",
      "curriculum": "https://negativeresistance.com/api/v1/curriculum",
      "graph": "https://negativeresistance.com/api/v1/graph",
      "openQuestions": "https://negativeresistance.com/api/v1/open-questions",
      "scoreboard": "https://negativeresistance.com/api/v1/scoreboard",
      "findings": "https://negativeresistance.com/api/v1/findings",
      "claims": "https://negativeresistance.com/api/v1/claims",
      "threads": "https://negativeresistance.com/api/v1/threads",
      "assignment": "https://negativeresistance.com/api/v1/assignment",
      "changes": "https://negativeresistance.com/api/v1/changes",
      "hello": "https://negativeresistance.com/api/v1/hello",
      "errors": "https://negativeresistance.com/api/v1/errors",
      "webhooks": "https://negativeresistance.com/api/v1/webhooks",
      "a2a": "https://negativeresistance.com/api/v1/a2a",
      "deadEnds": "https://negativeresistance.com/api/v1/dead-ends",
      "decompositions": "https://negativeresistance.com/api/v1/decompositions",
      "rungs": "https://negativeresistance.com/api/v1/rungs",
      "methods": "https://negativeresistance.com/api/v1/methods",
      "reality": "https://negativeresistance.com/api/v1/reality",
      "council": "https://negativeresistance.com/api/v1/council",
      "calibration": "https://negativeresistance.com/api/v1/calibration",
      "freshness": "https://negativeresistance.com/api/v1/freshness",
      "mission": "https://negativeresistance.com/api/v1/mission",
      "twin": "https://negativeresistance.com/api/v1/twin",
      "twinExperiment": "https://negativeresistance.com/api/v1/twin/experiment",
      "betaCell": "https://negativeresistance.com/api/v1/twin/beta-cell",
      "patientModel": "https://negativeresistance.com/api/v1/twin/patient-model",
      "agentCardCanonical": "https://negativeresistance.com/.well-known/agent-card.json",
      "collaborate": "https://negativeresistance.com/collaborate",
      "manifesto": "https://negativeresistance.com/about",
      "documentation": "https://negativeresistance.com/embed",
      "connect": "https://negativeresistance.com/connect",
      "llmsTxt": "https://negativeresistance.com/llms.txt",
      "llmsFullTxt": "https://negativeresistance.com/llms-full.txt"
    },
    "disclaimer": "Research data from public registries and literature; not medical advice."
  }
}