{ "data": { "asOf": "2026-10-30T22:24:47.219Z", "dedupMethod": "exact cross-registry identifier matching; probabilistic = review only", "byRegistry": { "clinicaltrials_gov": 1 }, "canonicalTrial": { "canonicalId": "NCT06789445", "title": "A Study to Investigate the Safety of OpCT-001 in Adults Who Have Primary Photoreceptor Disease (CLARICO)", "scientificTitle": "A Phase 1/2a Study of Subretinal Administration of OpCT-001 Photoreceptor Precursor Cells Derived From iPSCs in Patients With Primary Photoreceptor Disease", "status": "recruiting", "studyType": "interventional", "phase": [ "PHASE1", "PHASE2" ], "conditions": [ "Primary Photoreceptor Disease", "Retinitis Pigmentosa (RP)", "Usher Syndrome", "Inherited Retinal Disease (IRD)", "Rod-Cone Dystrophy", "Rod-Cone Disease", "Retinal Degeneration", "Cone-Rod Disease (C-RD)", "Cone-Rod Dystrophy" ], "interventions": [ { "name": "OpCT-001", "type": "BIOLOGICAL", "description": "Cell therapy product composed of photoreceptor precursor cells derived from human induced pluripotent stem cells (iPSCs)." }, { "name": "OpCT-001", "type": "BIOLOGICAL", "description": "Cell therapy product composed of photoreceptor precursor cells derived from human iPSCs." } ], "sponsor": { "name": "BlueRock Therapeutics", "type": "INDUSTRY" }, "locations": [ { "city": "Los Angeles", "country": "United States", "facility": "University of Southern California /Children's Hospital of Los Angeles" }, { "city": "Miami", "country": "United States", "facility": "University of Miami, Bascom Palmer Eye Institute" }, { "city": "Philadelphia", "country": "United States", "facility": "Mid Atlantic Retina/ Wills Eye" }, { "city": "Dallas", "country": "United States", "facility": "Retina Foundation of the Southwest" }, { "city": "Madison", "country": "United States", "facility": "University of Wisconsin" } ], "outcomes": { "other": [], "primary": [ "Incidence and severity of ocular and non-ocular treatment-emergent adverse events (TEAEs) through the Week 52 visit" ], "secondary": [ "Change from baseline over time through the Week 52 visit in the treated portion of the study eye (SE) retina in outer retinal layer thickness as measured by spectral domain optical coherence tomography (SD-OCT)" ] }, "eligibility": { "sex": "ALL", "criteria": "Key Inclusion Criteria:\n\n* Confirmed genetic diagnosis of primary photoreceptor (PR) disease\n* Best corrected visual acuity (BCVA) in the study eye at Screening for Phase 1: Logmarithm of the minimum angle of resolution (LogMAR) 3.9 to LogMAR 1.3. 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