{ "data": { "asOf": "2026-10-30T22:25:00.990Z", "dedupMethod": "exact cross-registry identifier matching; probabilistic = review only", "byRegistry": { "clinicaltrials_gov": 1 }, "canonicalTrial": { "canonicalId": "NCT06783166", "title": "Assessing the Clinical Outcomes of Dapagliflozin Versus Acetazolamide in Patients With Acute Heart Failure", "scientificTitle": "Assessing the Clinical Outcomes of Dapagliflozin Versus Acetazolamide in Patients With Acute Heart Failure", "status": "completed", "studyType": "interventional", "phase": [ "PHASE2", "PHASE3" ], "conditions": [ "Acute Heart Failure" ], "interventions": [ { "name": "Dapagliflozin 10mg", "type": "DRUG", "description": "Dapagliflozin 10 mg is a medication classified as a sodium-glucose cotransporter-2 (SGLT-2) inhibitor." }, { "name": "Acetazolamide 500mg", "type": "DRUG", "description": "Acetazolamide 500 mg is a medication classified as a carbonic anhydrase inhibitor." } ], "sponsor": { "name": "Mansoura University", "type": "OTHER" }, "locations": [ { "city": "Al Mansurah", "country": "Egypt", "facility": "Noha Mansour" } ], "outcomes": { "other": [], "primary": [ "Change in dyspnea VAS (Visual analogue scale)" ], "secondary": [] }, "eligibility": { "sex": "ALL", "criteria": "Inclusion Criteria:\n\n1. Adults aged 18 years or older who are hospitalized for hypervolemic AHF, with evidence of congestion defined as either:\n\n * 2 of the following signs or symptoms: peripheral edema, ascites, jugular venous pressure \\> 10mmHg, orthopnea, paroxysmal nocturnal dyspnea, 5-pound weight gain, or signs of congestion on chest x-ray or lung ultrasound. OR\n * If pulmonary artery catheterization is available, a pulmonary capillary wedge pressure greater than 19 mmHg plus a systemic physical exam finding of hypervolemia from the list above.\n2. Randomized within 24 hours of hospitalization for AHF.\n3. Planned use of IV loop diuretic therapy during current hospitalization\n4. Estimated glomerular filtration rate (eGFR) of at least 25 ml/min/1.73m2 by the MDRD equation.\n\nExclusion Criteria:\n\n1. Unable to follow instructions.\n2. Treated with any proximal tubular diuretics.\n3. Systolic blood pressure of less than 90 mm Hg.\n4. 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