{
  "data": {
    "asOf": "2026-10-30T22:26:47.520Z",
    "dedupMethod": "exact cross-registry identifier matching; probabilistic = review only",
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    "canonicalTrial": {
      "canonicalId": "NCT06585787",
      "title": "A Study to Evaluate KarXT as a Treatment for Psychosis Associated With Alzheimer's Disease (ADEPT-4)",
      "scientificTitle": "A Phase 3, Randomized, Double-Blind, Placebo-Controlled, Parallel Group Study to Evaluate the Safety and Efficacy of KarXT for the Treatment of Psychosis Associated With Alzheimer's Disease",
      "status": "recruiting",
      "studyType": "interventional",
      "phase": [
        "PHASE3"
      ],
      "conditions": [
        "Alzheimer Disease"
      ],
      "interventions": [
        {
          "name": "KarXT",
          "type": "DRUG",
          "description": "Specified dose on specified days"
        },
        {
          "name": "Placebo",
          "type": "DRUG",
          "description": "Specified dose on specified days"
        }
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      "sponsor": {
        "name": "Karuna Therapeutics, Inc., a Bristol Myers Squibb company",
        "type": "INDUSTRY"
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          "city": "Chandler",
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          "country": "United States",
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          "facility": "Advanced Research Center, Inc."
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          "city": "Long Beach",
          "country": "United States",
          "facility": "Local Institution - 1230"
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          "city": "Los Angeles",
          "country": "United States",
          "facility": "USC - The Memory and Aging Center (MAC) - Alzheimer Disease Research Center (ADRC)"
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          "city": "Los Angeles",
          "country": "United States",
          "facility": "Local Institution - 1219"
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          "city": "Orange",
          "country": "United States",
          "facility": "Local Institution - 1001"
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          "city": "Orange",
          "country": "United States",
          "facility": "Local Institution - 1228"
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          "country": "United States",
          "facility": "Local Institution - 1043"
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          "city": "Rancho Cucamonga",
          "country": "United States",
          "facility": "Local Institution - 1213"
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          "city": "Farmington",
          "country": "United States",
          "facility": "University of Connecticut Health Center"
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          "city": "Atlantis",
          "country": "United States",
          "facility": "Local Institution - 1225"
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          "city": "Bonita Springs",
          "country": "United States",
          "facility": "Envision Trials LLC"
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          "city": "Cutler Bay",
          "country": "United States",
          "facility": "Local Institution - 1138"
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          "city": "Daytona Beach",
          "country": "United States",
          "facility": "Arrow Clinical Trials"
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          "city": "Deerfield Beach",
          "country": "United States",
          "facility": "Local Institution - 1224"
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        {
          "city": "Doral",
          "country": "United States",
          "facility": "Local Institution - 1164"
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          "city": "Gulf Breeze",
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          "facility": "Local Institution - 1264"
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          "facility": "Local Institution - 1120"
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          "city": "Hialeah",
          "country": "United States",
          "facility": "Local Institution - 1237"
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          "facility": "Local Institution - 1229"
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          "city": "Lady Lake",
          "country": "United States",
          "facility": "Local Institution - 1040"
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          "city": "Miami",
          "country": "United States",
          "facility": "Local Institution - 1159"
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          "city": "Miami",
          "country": "United States",
          "facility": "Local Institution - 1021"
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          "city": "Miami",
          "country": "United States",
          "facility": "Local Institution - 1125"
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        {
          "city": "Miami",
          "country": "United States",
          "facility": "Local Institution - 1236"
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          "city": "Miami",
          "country": "United States",
          "facility": "Local Institution - 1115"
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          "city": "Miami",
          "country": "United States",
          "facility": "Local Institution - 1010"
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        {
          "city": "Miami",
          "country": "United States",
          "facility": "Local Institution - 1143"
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          "city": "Miami",
          "country": "United States",
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          "city": "Miami",
          "country": "United States",
          "facility": "Local Institution - 1129"
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        {
          "city": "Miami",
          "country": "United States",
          "facility": "Local Institution - 1150"
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        {
          "city": "Miami",
          "country": "United States",
          "facility": "Local Institution - 1006"
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        {
          "city": "Miami",
          "country": "United States",
          "facility": "Local Institution - 1111"
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        {
          "city": "Miami",
          "country": "United States",
          "facility": "Local Institution - 1158"
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        {
          "city": "Miami",
          "country": "United States",
          "facility": "Local Institution - 1235"
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        {
          "city": "Miami",
          "country": "United States",
          "facility": "Local Institution - 1147"
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        {
          "city": "Miami",
          "country": "United States",
          "facility": "Local Institution - 1234"
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        {
          "city": "Miami",
          "country": "United States",
          "facility": "Local Institution - 1105"
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          "city": "Miami",
          "country": "United States",
          "facility": "Local Institution - 1157"
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          "city": "Miami Gardens",
          "country": "United States",
          "facility": "Local Institution - 1126"
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          "city": "Miami Lakes",
          "country": "United States",
          "facility": "Local Institution - 1209"
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          "city": "Miami Lakes",
          "country": "United States",
          "facility": "Local Institution - 1118"
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          "city": "Naples",
          "country": "United States",
          "facility": "Aqualane Clinical Research"
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          "city": "Ocoee",
          "country": "United States",
          "facility": "Sensible HealthCare, LLC"
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          "city": "Orlando",
          "country": "United States",
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          "city": "Orlando",
          "country": "United States",
          "facility": "Nova Psychiatry"
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          "city": "Orlando",
          "country": "United States",
          "facility": "Combined Research Orlando Phase I-IV LLC"
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          "city": "Ormond Beach",
          "country": "United States",
          "facility": "Local Institution - 1204"
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          "city": "Port Orange",
          "country": "United States",
          "facility": "Local Institution - 1205"
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          "city": "Sweetwater",
          "country": "United States",
          "facility": "Local Institution - 1133"
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          "city": "Tampa",
          "country": "United States",
          "facility": "Local Institution - 1123"
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          "city": "Tampa",
          "country": "United States",
          "facility": "Guardian Angel Research"
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          "city": "Tampa",
          "country": "United States",
          "facility": "Interventional Psychiatry of Tampa Bay"
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          "city": "The Villages",
          "country": "United States",
          "facility": "Charter Research"
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          "city": "Wellington",
          "country": "United States",
          "facility": "Local Institution - 1233"
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          "city": "West Palm Beach",
          "country": "United States",
          "facility": "Premiere Research Institute at Palm Beach Neurology, PA"
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          "city": "Atlanta",
          "country": "United States",
          "facility": "Agile Clinical Research Trials, LLC"
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          "city": "Belmont",
          "country": "United States",
          "facility": "McLean Hospital"
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          "city": "Boston",
          "country": "United States",
          "facility": "Tufts Medical Center - 800 Washington St - PPDS"
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          "city": "North Dartmouth",
          "country": "United States",
          "facility": "Boston Neuro Research Center"
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          "city": "South Dartmouth",
          "country": "United States",
          "facility": "Local Institution - 1250"
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          "city": "Springfield",
          "country": "United States",
          "facility": "Elixia Health - Springfield - Elixia - PPDS"
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          "city": "Bloomfield Township",
          "country": "United States",
          "facility": "Neurobehavioral Medicine Group (NBMG)"
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          "city": "Flowood",
          "country": "United States",
          "facility": "Precise Research Centers"
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          "city": "St Louis",
          "country": "United States",
          "facility": "Tekton Research, LLC - Saint Louis Psychiatry - PPDS"
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          "city": "Toms River",
          "country": "United States",
          "facility": "Advanced Memory Research Institute - CenExel - PPDS"
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          "city": "Toms River",
          "country": "United States",
          "facility": "Local Institution - 1232"
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          "city": "New Windsor",
          "country": "United States",
          "facility": "Mid Hudson Medical Research PLLC"
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          "city": "Syracuse",
          "country": "United States",
          "facility": "Local Institution - 1231"
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        {
          "city": "Syracuse",
          "country": "United States",
          "facility": "SUNY Upstate Medical University"
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          "city": "Woodmere",
          "country": "United States",
          "facility": "Five Towns Neurology, PC"
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          "city": "Greensboro",
          "country": "United States",
          "facility": "Triad Clinical Trials - 515 College Rd"
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          "city": "Matthews",
          "country": "United States",
          "facility": "AMC Research, LLC - Flourish - PPDS"
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          "city": "Morehead City",
          "country": "United States",
          "facility": "Local Institution - 5005"
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          "city": "Morehead City",
          "country": "United States",
          "facility": "West Clinical Research"
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          "city": "Shelby",
          "country": "United States",
          "facility": "Local Institution - 1252"
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          "city": "Cleveland",
          "country": "United States",
          "facility": "Local Institution - 1265"
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          "city": "Columbus",
          "country": "United States",
          "facility": "Ohio State University"
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          "city": "Dayton",
          "country": "United States",
          "facility": "Local Institution - 1258"
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          "city": "Independence",
          "country": "United States",
          "facility": "Insight Clinical Trials LLC - Independence"
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          "city": "Oklahoma City",
          "country": "United States",
          "facility": "The Rivus Wellness & Research Institute"
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          "city": "Providence",
          "country": "United States",
          "facility": "Alzheimer's Disease and Memory Disorders Center at Rhode Island Hospital"
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          "city": "Columbia",
          "country": "United States",
          "facility": "Local Institution - 1267"
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          "city": "Nashville",
          "country": "United States",
          "facility": "Vanderbilt Psychiatric Hospital"
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          "city": "Austin",
          "country": "United States",
          "facility": "Senior Adults Specialty Research"
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          "city": "Dallas",
          "country": "United States",
          "facility": "Local Institution - 1260"
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        {
          "city": "DeSoto",
          "country": "United States",
          "facility": "Epic Medical Research LLC - DeSoto"
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          "city": "El Paso",
          "country": "United States",
          "facility": "Advanced Neuro Research Center - El Paso"
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          "city": "Fort Worth",
          "country": "United States",
          "facility": "Local Institution - 1262"
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          "city": "Houston",
          "country": "United States",
          "facility": "Local Institution - 1261"
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          "city": "Irving",
          "country": "United States",
          "facility": "University Hills Clinical Research - 102 Decker Ct"
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          "city": "Plano",
          "country": "United States",
          "facility": "Local Institution - 1238"
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          "city": "San Antonio",
          "country": "United States",
          "facility": "Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases"
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          "city": "Stafford",
          "country": "United States",
          "facility": "Local Institution - 1134"
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          "city": "Salem",
          "country": "United States",
          "facility": "Local Institution - 1266"
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          "city": "Vienna",
          "country": "United States",
          "facility": "Conquest Research, LLC - Virginia - Vienna"
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          "city": "Bellevue",
          "country": "United States",
          "facility": "Northwest Clinical Research Center"
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          "city": "Kirkland",
          "country": "United States",
          "facility": "Local Institution - 1254"
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          "city": "Ciudad Autónoma de Buenos Aires",
          "country": "Argentina",
          "facility": "CINME S.A. - Centro de Investigaciones Metabólicas - Viamonte 2213/2215"
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          "city": "Ciudad Autónoma de Buenos Aires",
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          "city": "Ciudad Autónoma de Buenos Aires",
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          "facility": "Instituto Médico de la Fundación Estudios Clínicos"
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          "city": "Buenos Aires",
          "country": "Argentina",
          "facility": "Hospital Italiano de Buenos Aires"
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          "city": "Buenos Aires",
          "country": "Argentina",
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          "city": "Buenos Aires",
          "country": "Argentina",
          "facility": "Fundación Para La Lucha Contra Las Enfermedades Neurológicas de La Infancia - FLENI"
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          "city": "Córdoba",
          "country": "Argentina",
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          "city": "Córdoba",
          "country": "Argentina",
          "facility": "Instituto Privado Kremer"
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          "city": "Jette",
          "country": "Belgium",
          "facility": "Local Institution - 2806"
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          "city": "Roeselare",
          "country": "Belgium",
          "facility": "Local Institution - 2803"
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          "city": "Alken",
          "country": "Belgium",
          "facility": "Local Institution - 2804"
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          "city": "Bruges",
          "country": "Belgium",
          "facility": "Local Institution - 2807"
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          "city": "Kortrijk",
          "country": "Belgium",
          "facility": "Local Institution - 2805"
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          "city": "Brasília",
          "country": "Brazil",
          "facility": "L2 Ip - Instituto de Pesquisas Clinicas Ltda - ME"
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          "city": "São Paulo",
          "country": "Brazil",
          "facility": "CPQuali Pesquisa Clínica Sao Paulo"
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          "city": "São Paulo",
          "country": "Brazil",
          "facility": "BR Trials - Pesquisa Clínica"
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          "city": "São Paulo",
          "country": "Brazil",
          "facility": "Hospital Alemao Oswaldo Cruz (HAOC)"
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          "city": "São Paulo",
          "country": "Brazil",
          "facility": "Clinilive"
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          "city": "Rio de Janeiro",
          "country": "Brazil",
          "facility": "Ruschel Medicina"
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        {
          "city": "São Paulo",
          "country": "Brazil",
          "facility": "Instituto de Psiquiatria HC FMUSP"
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          "city": "Sofia",
          "country": "Bulgaria",
          "facility": "Local Institution - 4506"
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        {
          "city": "Plovdiv",
          "country": "Bulgaria",
          "facility": "University Multiprofile Hospital for Active Treatment Sveti Georgi EAD-66 Peshtersko Shosse blvd"
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          "city": "Rousse",
          "country": "Bulgaria",
          "facility": "University Multiprofile Hospital For Active Treatment Kanev AD"
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          "city": "Sofia",
          "country": "Bulgaria",
          "facility": "Medical Center Medika 2005 - Branch Sofia"
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        {
          "city": "Sofia",
          "country": "Bulgaria",
          "facility": "Local Institution - 4510"
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        {
          "city": "Beijing",
          "country": "China",
          "facility": "China-Japan Friendship Hospital"
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        {
          "city": "Beijing",
          "country": "China",
          "facility": "Beijing Anding Hospital Capital Medical University"
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        {
          "city": "Beijing",
          "country": "China",
          "facility": "Beijing Hospital"
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        {
          "city": "Chongqing",
          "country": "China",
          "facility": "The First Affiliated Hospital of Chongqing Medical University"
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        {
          "city": "Guangzhou",
          "country": "China",
          "facility": "Local Institution - 7008"
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        {
          "city": "Guangzhou",
          "country": "China",
          "facility": "Guangdong Provincial People's Hospital"
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          "city": "Shenzhen",
          "country": "China",
          "facility": "Shenzhen Kangning Hospital"
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        {
          "city": "Nanjing",
          "country": "China",
          "facility": "The Second Affiliated Hospital of Nanjing Medical University - Main Campus"
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        {
          "city": "Nanjing",
          "country": "China",
          "facility": "Nanjing Brain Hospital"
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        {
          "city": "Zhenjiang",
          "country": "China",
          "facility": "Affiliated Hospital of Jiangsu University"
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        {
          "city": "Xi'an",
          "country": "China",
          "facility": "The Mental Health Center of Xi'an"
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        {
          "city": "Shanghai",
          "country": "China",
          "facility": "Shanghai Mental Health Center - PPDS"
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        {
          "city": "Shanghai",
          "country": "China",
          "facility": "Tongji Hospital of Tongji University"
        },
        {
          "city": "Shanghai",
          "country": "China",
          "facility": "Local Institution - 7026"
        },
        {
          "city": "Chengdu",
          "country": "China",
          "facility": "West China Hospital Sichuan University"
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        {
          "city": "Tianjin",
          "country": "China",
          "facility": "Tianjin Anding Hospital(Tianjin mental Health Center)"
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        {
          "city": "Hangzhou",
          "country": "China",
          "facility": "Sir Run Run Shaw Hospital Zhejiang University School of Medicine - Qiantang Campus"
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        {
          "city": "Hangzhou",
          "country": "China",
          "facility": "Zhejiang Hospital - Lingyin Campus"
        },
        {
          "city": "Hangzhou",
          "country": "China",
          "facility": "Zhejiang Provincial People's Hospital"
        },
        {
          "city": "Ningbo",
          "country": "China",
          "facility": "The Affiliated Kangning Hospital of Ningbo University - Zhuangshi Campus"
        },
        {
          "city": "Changsha",
          "country": "China",
          "facility": "Xiangya Hospital Central South University"
        },
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          "city": "Kunming",
          "country": "China",
          "facility": "First Affiliated Hospital of Kunming Medical University"
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        {
          "city": "Zagreb",
          "country": "Croatia",
          "facility": "Local Institution - 4102"
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        {
          "city": "Zagreb",
          "country": "Croatia",
          "facility": "Local Institution - 4105"
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        {
          "city": "Zagreb",
          "country": "Croatia",
          "facility": "Local Institution - 4106"
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        {
          "city": "Zagreb",
          "country": "Croatia",
          "facility": "Local Institution - 4101"
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        {
          "city": "Zagreb",
          "country": "Croatia",
          "facility": "Local Institution - 4104"
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          "city": "Nice",
          "country": "France",
          "facility": "Local Institution - 2510"
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        {
          "city": "Tours",
          "country": "France",
          "facility": "CHRU de Tours - Hôpital Bretonneau"
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        {
          "city": "Toulouse",
          "country": "France",
          "facility": "Local Institution - 2512"
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        {
          "city": "Toulouse",
          "country": "France",
          "facility": "CHU de Toulouse- Gerontopole"
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        {
          "city": "Böblingen",
          "country": "Germany",
          "facility": "Local Institution - 2407"
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        {
          "city": "Homburg",
          "country": "Germany",
          "facility": "Local Institution - 2402"
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          "city": "Berlin",
          "country": "Germany",
          "facility": "Local Institution - 2406"
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        {
          "city": "Erbach im Odenwald",
          "country": "Germany",
          "facility": "Local Institution - 2404"
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        {
          "city": "Frankfurt am Main",
          "country": "Germany",
          "facility": "Local Institution - 2405"
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          "city": "Athens",
          "country": "Greece",
          "facility": "Local Institution - 4803"
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          "facility": "Local Institution - 4802"
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          "city": "Heraklion",
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          "city": "Thessaloniki",
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          "facility": "Local Institution - 4811"
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          "city": "Pécs",
          "country": "Hungary",
          "facility": "Psychotech Kft."
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          "city": "Szeged",
          "country": "Hungary",
          "facility": "Local Institution - 4610"
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          "city": "Gyöngyös",
          "country": "Hungary",
          "facility": "Clinexpert Gyöngyös Kft."
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        {
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          "city": "Fukuoka",
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        {
          "city": "Hiroshima",
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          "facility": "Funairi nou clinic"
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        {
          "city": "Kumamoto",
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          "facility": "Tsutsujimental Hospital"
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          "city": "Poznan",
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          "facility": "Centrum Medyczne HCP Szpital im. Jana Pawla II"
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          "city": "Iława",
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          "facility": "Neyromed LLC - Uzhhorod"
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        "primary": [
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        "secondary": [
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          "Number of participants with anticholinergic symptoms",
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    "disclaimer": "Research data from public registries and literature; not medical advice."
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}