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      "canonicalId": "NCT06491563",
      "title": "Study to Investigate the Efficacy and Safety of Regimens Containing BRII-179, BRII-835, and PEG-IFNα Treating Chronic Hepatitis B Virus (HBV) Infection (ENRICH)",
      "scientificTitle": "A Phase 2 Multicenter, Open-label Study to Investigate the Efficacy and Safety of Regimens Containing BRII-179, BRII-835, and Pegylated Interferon Alpha (PEG-IFNα) for the Treatment of Chronic Hepatitis B Virus (HBV) Infection (ENRICH)",
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          "type": "BIOLOGICAL",
          "description": "BRII-179 will be given via intramuscular injection"
        },
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          "name": "BRII-835 (VIR-2218)",
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          "description": "BRII-835 will be given via subcutaneous injection"
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          "type": "BIOLOGICAL",
          "description": "PEG-IFNα will be given via subcutaneous injection"
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      "sponsor": {
        "name": "Brii Biosciences Limited",
        "type": "INDUSTRY"
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          "city": "Beijing",
          "country": "China",
          "facility": "Investigative Site 86004"
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        {
          "city": "Beijing",
          "country": "China",
          "facility": "Investigative Site 86009"
        },
        {
          "city": "Xiamen",
          "country": "China",
          "facility": "Investigative Site 86015"
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          "city": "Foshan",
          "country": "China",
          "facility": "Investigative Site 86012"
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          "city": "Guangzhou",
          "country": "China",
          "facility": "Investigative Site 86001"
        },
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          "city": "Guangzhou",
          "country": "China",
          "facility": "Investigative Site 86013"
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          "city": "Shenzhen",
          "country": "China",
          "facility": "Investigative Site 86002"
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          "city": "Shanghai",
          "country": "China",
          "facility": "Investigative Site 86003"
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          "city": "Shanghai",
          "country": "China",
          "facility": "Investigative Site 86008"
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          "country": "China",
          "facility": "Investigative Site 86007"
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          "country": "China",
          "facility": "Investigative Site 86011"
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          "country": "China",
          "facility": "Investigative Site 86005"
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        ],
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          "Percentage of participants with treatment-emergent adverse events (TEAEs)",
          "Percentage of participants with serious adverse events (SAEs)",
          "Clinical assessments including laboratory measurements",
          "Appearance of anti-HBs at any timepoint",
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        "criteria": "Inclusion Criteria:\n\n* 1\\. Male or female aged 18-60 years.\n* 2\\. Body mass index ≥ 18 kg/m2 and ≤ 32 kg/m2.\n* 3\\. Chronic HBV infection for ≥ 6 months.\n* 4\\. On NRTI therapy for ≥ 6 months.\n\nExclusion Criteria:\n\n* 1\\. Any clinically significant chronic or acute medical condition that makes the participant unsuitable for participation.\n* 2\\. Significant liver fibrosis or cirrhosis.\n* 3\\. History or evidence of drug or alcohol abuse.\n* 4\\. History of intolerance to SC or IM injection.\n* 5\\. History of chronic liver disease from any cause other than chronic HBV infection.\n* 6\\. History of hepatic decompensation.\n* 7\\. Contraindications to the use of PEG-IFNα.",
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