{ "data": { "asOf": "2026-10-30T22:27:51.773Z", "dedupMethod": "exact cross-registry identifier matching; probabilistic = review only", "byRegistry": { "clinicaltrials_gov": 1 }, "canonicalTrial": { "canonicalId": "NCT06122051", "title": "Dynamic Chest X-ray With Simultaneous Spirometry", "scientificTitle": "Dynamic Chest X-ray With Simultaneous Spirometry", "status": "completed", "studyType": "observational", "phase": [], "conditions": [ "Cystic Fibrosis" ], "interventions": [ { "name": "Dynamic chest x-ray", "type": "RADIATION", "description": "Group A and Group B- posterior-anterior dynamic chest x-ray film (Group A, This will represent an additional intervention not part of standard clinical care) (Group B, People with CF, already have this as part of their annual review process)" }, { "name": "Spirometry", "type": "DIAGNOSTIC_TEST", "description": "Group A and Group B- Spirometry lung function test (Group A, This will represent an additional intervention not part of standard clinical care) (Group B, People with CF, already have this as part of their annual review process)" } ], "sponsor": { "name": "Liverpool Heart and Chest Hospital NHS Foundation Trust", "type": "OTHER" }, "locations": [ { "city": "Liverpool", "country": "United Kingdom", "facility": "Liverpool Heart and Chest Hospital" } ], "outcomes": { "other": [ "Correlation between DCR metrics and BMI for people with CF", "Correlation between DCR metrics and microbial colonisation for people with CF", "Correlation between DCR metrics and co-morbidities for people with CF", "Correlation between DCR metrics and key CF respiratory medication for people with CF" ], "primary": [ "Correlation between Dynamic chest X-ray (DCR) metrics And Spirometry metrics in people with Cystic fibrosis and those with no underlying respiratory conditions" ], "secondary": [ "Correlation between DCR metrics and Spirometry metrics over time, as recorded in annual review CF clinic attendance (non-simultaneous)" ] }, "eligibility": { "sex": "ALL", "criteria": "Part A: Real-time paired DCR and Spirometry in Healthy cohort with no underlying respiratory diagnosis\n\nInclusion criteria:\n\n* Age: ≥ 17 years old and \\<\\_ 50 years old\n* No underlying respiratory illness (chronic or acute). Individuals with an Asthma diagnosis requiring short-acting bronchodilators only will be eligible\n* Able to provide informed consent\n\nExclusion criteria:\n\nGeneral exclusion criteria:\n\nAny of:\n\n* Potentially pregnant or lactating\n* Inability to provide informed consent\n* Unable or unwilling to sit to perform Dynamic chest x-ray/Spirometry in the radiology department\n* Unable or unwilling to follow Spirometry breathing instructions (e.g., holding breath or taking a deep breath)\n* Unable to perform reproducible spirometry and/or full pulmonary function studies within American Thoracic Society and European Society joint criteria\n* Significant radiation exposure within the last year (for example, numerous CT scans of chest)\n* Involved, either currently or recently, in other studies involved non-routine exposure to sources of ionising radiation\n* Any serious or active medical or psychiatric illness, which in the opinion of the investigators, would interfere with subject treatment, assessment, or compliance with the protocol\n* Inability to complete spirometry in 20 seconds.\n* Current Chest infection\n\nSpirometry exclusion criteria\n\nAny of:\n\n* Unstable cardiovascular status, recent myocardial infarction or pulmonary embolism (within 6 weeks)\n* Haemoptysis of unknown aetiology (within 6 weeks)\n* Pneumothorax (present, or occurring within 6 weeks)\n* Within 24 hours of bronchoscopy\n* Thoracic, abdominal or cerebral aneurysm\n* Recent eye surgery or increased intraocular pressure\n* Recent thoracic or abdominal surgery\n* Acute nausea, vomiting or diarrhoea\n* Pregnancy\n* Undergoing treatment for tuberculosis\n\nPart B: Real-time paired DCR and spirometry in a CF subgroup\n\nInclusion criteria:\n\n* Age: ≥ 17 years old and\n* Attending the adult CF Unit at Liverpool heart and Chest Hospital and\n* Confirmed CF diagnosis (positive sweat test in childhood and by genotyping) and\n* Able to provide informed consent\n\nGeneral exclusion criteria, same as Group A (see above) plus:\n\n* Recipient of Lung transplant\n* Current exacerbation Spirometry exclusion criteria (same as for Group A, see above)", "maximumAge": "50 Years", "minimumAge": "17 Years" }, "enrollment": { "type": "ACTUAL", "count": 104 }, "startDate": "2023-12-05", "completionDate": "2025-07-31", "lastUpdated": "2026-10-15T00:00:00.000Z", "firstPosted": "2023-11-08T00:00:00.000Z", "resultsAvailable": false, "sourceRegistries": [ "clinicaltrials_gov" ], "sourceUrls": [ "https://clinicaltrials.gov/study/NCT06122051" ] }, "identifiers": [ { "idType": "nct", "idValue": "NCT06122051", "declaredBy": "clinicaltrials_gov" } ], "sourceRecords": [ { "registry": "clinicaltrials_gov", "registryName": "ClinicalTrials.gov", "license": "public-domain", "sourceId": "NCT06122051", "sourceUrl": "https://clinicaltrials.gov/study/NCT06122051", "sourceStatus": "COMPLETED", "retrievedAt": "2026-10-28T04:32:26.458Z", "payloadSha256": "91be2828aab8f19ac340971fe6cc33d9b14abe1f9a48512dd0c7903e05ed2d34", "piiRedacted": true } ], "citation": { "canonicalId": "NCT06122051", "sources": [ { "registry": "clinicaltrials_gov", "registryName": "ClinicalTrials.gov", "license": "public-domain", "sourceId": "NCT06122051", "verifyAt": "https://clinicaltrials.gov/study/NCT06122051", "retrievedAt": "2026-10-28T04:32:26.458Z", "payloadSha256": "91be2828aab8f19ac340971fe6cc33d9b14abe1f9a48512dd0c7903e05ed2d34", "text": "ClinicalTrials.gov, record NCT06122051 (https://clinicaltrials.gov/study/NCT06122051), retrieved 2026-10-28, licence: public-domain." } ], "crossRegistry": false, "dedupMethod": "exact cross-registry identifier matching; probabilistic = review only", "text": "Trial NCT06122051, registered in ClinicalTrials.gov, retrieved 2026-10-28. 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