{ "data": { "asOf": "2026-10-30T22:26:03.556Z", "dedupMethod": "exact cross-registry identifier matching; probabilistic = review only", "byRegistry": { "clinicaltrials_gov": 1 }, "canonicalTrial": { "canonicalId": "NCT06043700", "title": "A Community-Based Screening Program to Identify Participants at High Risk for Amyloid Pathology", "scientificTitle": "A Community-Based Screening Program to Identify, Using Blood-Based Biomarkers, Individuals With or Without Alzheimer's Disease Symptoms Who Are at High Risk for Brain Amyloid Pathology", "status": "active", "studyType": "observational", "phase": [], "conditions": [ "Alzheimer's Disease" ], "interventions": [ { "name": "No Intervention", "type": "OTHER", "description": "No treatment intervention will be administered." } ], "sponsor": { "name": "Eisai Limited", "type": "INDUSTRY" }, "locations": [ { "city": "Clermont", "country": "United States", "facility": "Eisai Site #3" }, { "city": "Lady Lake", "country": "United States", "facility": "Eisai Site #1" }, { "city": "District Heights", "country": "United States", "facility": "Eisai Site #2" } ], "outcomes": { "other": [], "primary": [ "Number of Participants With Low, Medium, and High Amyloid Pathology" ], "secondary": [] }, "eligibility": { "sex": "ALL", "criteria": "Inclusion Criteria:\n\n1. Male or female, age 50 to 80 years inclusive, at the time of informed consent\n\n \\- Those 50 to 64 years of age must have 1 of the following risk factors confirmed prior to blood sample collection:\n * First degree relative with dementia onset before age 75,\n * Known before screening to have at least 1 Apolipoprotein E4 (APOE4) allele, or\n * Known before screening to have elevated brain amyloid according to previous positron emission tomography (PET), cerebrospinal fluid (CSF), or blood testing\n2. Provide written informed consent\n3. Willing and able to comply with all aspects of the protocol\n4. Willing to be referred to a clinical site if the assessment results meet the criteria\n\nExclusion Criteria:\n\n1. Known uncontrolled medical conditions (example, cardiac, respiratory, gastrointestinal, psychiatric, renal disease, malignant neoplasm)\n2. Participation in an interventional clinical trial study at the time of consent", "maximumAge": "80 Years", "minimumAge": "50 Years", "healthyVolunteers": true }, "enrollment": { "type": "ESTIMATED", "count": 2000 }, "startDate": "2023-09-12", "completionDate": "2028-03-31", "lastUpdated": "2026-10-27T00:00:00.000Z", "firstPosted": "2023-09-21T00:00:00.000Z", "resultsAvailable": false, "sourceRegistries": [ "clinicaltrials_gov" ], "sourceUrls": [ "https://clinicaltrials.gov/study/NCT06043700" ] }, "identifiers": [ { "idType": "nct", "idValue": "NCT06043700", "declaredBy": "clinicaltrials_gov" } ], "sourceRecords": [ { "registry": "clinicaltrials_gov", "registryName": "ClinicalTrials.gov", "license": "public-domain", "sourceId": "NCT06043700", "sourceUrl": "https://clinicaltrials.gov/study/NCT06043700", "sourceStatus": "ACTIVE_NOT_RECRUITING", "retrievedAt": "2026-10-28T04:32:50.757Z", "payloadSha256": "1df0d2e62414bc34281bb8fdca9e9c1e85c650954baaf567507bd7568b559783", "piiRedacted": true } ], "citation": { "canonicalId": "NCT06043700", "sources": [ { "registry": "clinicaltrials_gov", "registryName": "ClinicalTrials.gov", "license": "public-domain", "sourceId": "NCT06043700", "verifyAt": "https://clinicaltrials.gov/study/NCT06043700", "retrievedAt": "2026-10-28T04:32:50.757Z", "payloadSha256": "1df0d2e62414bc34281bb8fdca9e9c1e85c650954baaf567507bd7568b559783", "text": "ClinicalTrials.gov, record NCT06043700 (https://clinicaltrials.gov/study/NCT06043700), retrieved 2026-10-28, licence: public-domain." } ], "crossRegistry": false, "dedupMethod": "exact cross-registry identifier matching; probabilistic = review only", "text": "Trial NCT06043700, registered in ClinicalTrials.gov, retrieved 2026-10-28. Verify at the source URLs listed; each retrieval is checksummed.", "note": "Only one registry is known to hold this trial. Absence from the others is not evidence it was not registered there." }, "provenanceNote": "Personal contact fields (names, emails, phone numbers, addresses) are stripped from every stored payload. No participant-level data is collected or served." }, "_meta": { "api": "The Last Economy Wire: World Trials API", "version": "1.0", "schemaVersion": "1", "correlationId": "req_LA2YYLmdMkJw", "generatedAt": "2026-10-30T22:26:03.557Z", "documentation": "https://negativeresistance.com/embed", "license": "Free for any use. Attribution appreciated.", "degraded": false, "provenance": { "sources": [ "clinicaltrials_gov" ], "attribution": { "clinicaltrials_gov": "ClinicalTrials.gov: licence: public-domain, https://clinicaltrials.gov/data-api/api-docs" }, "dedupMethod": "exact cross-registry identifier matching; probabilistic = review only", "limitations": [], "provenanceEndpoint": "/api/v1/sources" }, "freshness": { "newestEvidenceAt": null, "lastSyncedAt": { "clinicaltrials_gov": "2026-10-28T04:33:30.663Z" }, "degradedSources": [], "worldwide": false, "maxAgeHours": 65.9, "fromCache": false }, "links": { "discovery": "https://negativeresistance.com/api/v1", "openapi": "https://negativeresistance.com/api/v1/openapi.json", "mcp": "https://negativeresistance.com/api/v1/mcp", "agentCard": "https://negativeresistance.com/.well-known/agent.json", "aiPlugin": "https://negativeresistance.com/.well-known/ai-plugin.json", "sdk": "https://negativeresistance.com/api/v1/sdk", "status": "https://negativeresistance.com/api/v1/status", "provenance": "https://negativeresistance.com/api/v1/sources", "contract": "https://negativeresistance.com/api/v1/contract", "curriculum": "https://negativeresistance.com/api/v1/curriculum", "graph": "https://negativeresistance.com/api/v1/graph", "openQuestions": "https://negativeresistance.com/api/v1/open-questions", "scoreboard": "https://negativeresistance.com/api/v1/scoreboard", "findings": "https://negativeresistance.com/api/v1/findings", "claims": "https://negativeresistance.com/api/v1/claims", "threads": "https://negativeresistance.com/api/v1/threads", "assignment": "https://negativeresistance.com/api/v1/assignment", "changes": "https://negativeresistance.com/api/v1/changes", "hello": "https://negativeresistance.com/api/v1/hello", "errors": "https://negativeresistance.com/api/v1/errors", "webhooks": "https://negativeresistance.com/api/v1/webhooks", "a2a": "https://negativeresistance.com/api/v1/a2a", "deadEnds": "https://negativeresistance.com/api/v1/dead-ends", "decompositions": "https://negativeresistance.com/api/v1/decompositions", "rungs": "https://negativeresistance.com/api/v1/rungs", "methods": "https://negativeresistance.com/api/v1/methods", "reality": "https://negativeresistance.com/api/v1/reality", "council": "https://negativeresistance.com/api/v1/council", "calibration": "https://negativeresistance.com/api/v1/calibration", "freshness": "https://negativeresistance.com/api/v1/freshness", "mission": "https://negativeresistance.com/api/v1/mission", "twin": "https://negativeresistance.com/api/v1/twin", "twinExperiment": "https://negativeresistance.com/api/v1/twin/experiment", "betaCell": "https://negativeresistance.com/api/v1/twin/beta-cell", "patientModel": "https://negativeresistance.com/api/v1/twin/patient-model", "agentCardCanonical": "https://negativeresistance.com/.well-known/agent-card.json", "collaborate": "https://negativeresistance.com/collaborate", "manifesto": "https://negativeresistance.com/about", "documentation": "https://negativeresistance.com/embed", "connect": "https://negativeresistance.com/connect", "llmsTxt": "https://negativeresistance.com/llms.txt", "llmsFullTxt": "https://negativeresistance.com/llms-full.txt" }, "disclaimer": "Research data from public registries and literature; not medical advice." } }