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      "canonicalId": "NCT05668741",
      "title": "A Phase 1/2 Study of VX-522 in Participants With Cystic Fibrosis (CF)",
      "scientificTitle": "A Phase 1/2 Dose Escalation Study Evaluating the Safety, and Tolerability and Efficacy of VX-522 in Subjects 18 Years of Age and Older With Cystic Fibrosis and a CFTR Genotype Not Responsive to CFTR Modulator Therapy",
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      "studyType": "interventional",
      "phase": [
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        "PHASE2"
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      "conditions": [
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      "interventions": [
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          "name": "VX-522 mRNA therapy",
          "type": "DRUG",
          "description": "Oral inhalation using nebulizer."
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        {
          "name": "IVA",
          "type": "DRUG",
          "description": "Tablet for oral administration."
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      "sponsor": {
        "name": "Vertex Pharmaceuticals Incorporated",
        "type": "INDUSTRY"
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      "locations": [
        {
          "city": "Birmingham",
          "country": "United States",
          "facility": "University of Alabama at Birmingham - Child Health Research Unit"
        },
        {
          "city": "Long Beach",
          "country": "United States",
          "facility": "Memorial Health Services on behalf of Long Beach Memorial Medical Center d/b/a Miller Children's Hospital Long Beach"
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          "city": "Palo Alto",
          "country": "United States",
          "facility": "Stanford University - Palo Alto - Pulmonology"
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          "country": "United States",
          "facility": "National Jewish Health"
        },
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          "city": "Kansas City",
          "country": "United States",
          "facility": "Clinical & Translational Science Unit (CTSU) - Pulmonology"
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        {
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          "country": "United States",
          "facility": "PAREXEL International - Baltimore"
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        {
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          "country": "United States",
          "facility": "The Johns Hopkins University - Johns Hopkins Hospital - Pulmonology"
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          "city": "Boston",
          "country": "United States",
          "facility": "MGH - MGfC Pediatric Cystic Fibrosis Center"
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        {
          "city": "Boston",
          "country": "United States",
          "facility": "Boston Children's Hospital"
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          "city": "Minneapolis",
          "country": "United States",
          "facility": "University of Minnesota -Pulmonology"
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        {
          "city": "St Louis",
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          "facility": "St. Louis Children's Hospital - Pulmonology"
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          "country": "United States",
          "facility": "UC Health Holmes Hospital"
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          "city": "Charleston",
          "country": "United States",
          "facility": "Medical University of South Carolina - Pulmonology"
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        {
          "city": "Salt Lake City",
          "country": "United States",
          "facility": "University of Utah Hospital - Pulmonology"
        },
        {
          "city": "Melbourne",
          "country": "Australia",
          "facility": "The Alfred Hospital - Pulmonology"
        },
        {
          "city": "Ghent",
          "country": "Belgium",
          "facility": "Universitair Ziekenhuis Gent"
        },
        {
          "city": "Calgary",
          "country": "Canada",
          "facility": "University of Calgary Medical Clinic of the Foothills Medical Centre"
        },
        {
          "city": "Québec",
          "country": "Canada",
          "facility": "IUCPQ Pavillon Recherche U-1771"
        },
        {
          "city": "Essen",
          "country": "Germany",
          "facility": "Ruhrlandklinik"
        },
        {
          "city": "Stockholm",
          "country": "Sweden",
          "facility": "Karolinska University Hospital - Pulmonology"
        },
        {
          "city": "Cambridge",
          "country": "United Kingdom",
          "facility": "Papworth Hospital NHS Foundation Trust"
        },
        {
          "city": "Glasgow",
          "country": "United Kingdom",
          "facility": "Queen Elizabeth University Hospital - Pulmonology"
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        {
          "city": "London",
          "country": "United Kingdom",
          "facility": "Royal Brompton Hospital"
        },
        {
          "city": "Manchester",
          "country": "United Kingdom",
          "facility": "Wythenshawe Hospital - OPD"
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        {
          "city": "Penarth",
          "country": "United Kingdom",
          "facility": "All Wales Adult Cystic Fibrosis Centre, University Hospital Llandough"
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        {
          "city": "Southampton",
          "country": "United Kingdom",
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