{ "data": { "asOf": "2026-10-30T22:27:52.257Z", "dedupMethod": "exact cross-registry identifier matching; probabilistic = review only", "byRegistry": { "clinicaltrials_gov": 1 }, "canonicalTrial": { "canonicalId": "NCT05554406", "title": "Testing New Therapies for Patients With Acute Myeloid Leukemia Who Are Newly Diagnosed and Have Not Yet Started Treatment (A MyeloMATCH Treatment Trial)", "scientificTitle": "A Randomized Phase II Study Comparing Cytarabine + Daunorubicin (7 + 3) vs (Daunorubicin and Cytarabine) Liposome, Cytarabine + Daunorubicin + Venetoclax, Azacitidine + Venetoclax, and (Daunorubicin and Cytarabine) Liposome + Venetoclax in Patients Aged 59 or Younger Who Are Considered High-Risk (Adverse) Acute Myeloid Leukemia As Determined by MYELOMATCH; A MYELOMATCH SubStudy", "status": "recruiting", "studyType": "interventional", "phase": [ "PHASE2" ], "conditions": [ "Acute Myeloid Leukemia", "Acute Myeloid Leukemia Arising From Previous Myelodysplastic/Myeloproliferative Neoplasm", "Acute Myeloid Leukemia Post Cytotoxic Therapy", "Acute Myeloid Leukemia, Myelodysplasia-Related" ], "interventions": [ { "name": "Azacitidine", "type": "DRUG", "description": "Given SC or IV" }, { "name": "Biospecimen Collection", "type": "PROCEDURE", "description": "Undergo collection of blood" }, { "name": "Bone Marrow Aspiration", "type": "PROCEDURE", "description": "Undergo bone marrow aspiration" }, { "name": "Cytarabine", "type": "DRUG", "description": "Given IV" }, { "name": "Daunorubicin Hydrochloride", "type": "DRUG", "description": "Given IV" }, { "name": "Echocardiography Test", "type": "PROCEDURE", "description": "Undergo ECHO" }, { "name": "Liposome-encapsulated Daunorubicin-Cytarabine", "type": "DRUG", "description": "Given IV" }, { "name": "Multigated Acquisition Scan", "type": "PROCEDURE", "description": "Undergo MUGA" }, { "name": "Venetoclax", "type": "DRUG", "description": "Given PO" } ], "sponsor": { "name": "National Cancer Institute (NCI)", "type": "NIH" }, "locations": [ { "city": "Birmingham", "country": "United States", "facility": "University of Alabama at Birmingham Cancer Center" }, { "city": "Phoenix", "country": "United States", "facility": "Mayo Clinic Hospital in Arizona" }, { "city": "Tucson", "country": "United States", "facility": "Banner University Medical Center - Tucson" }, { "city": "Tucson", "country": "United States", "facility": "University of Arizona Cancer Center-North Campus" }, { "city": "Little Rock", "country": "United States", "facility": "University of Arkansas for Medical Sciences" }, { "city": "Berkeley", "country": "United States", "facility": "Alta Bates Summit Medical Center-Herrick Campus" }, { "city": "Los Angeles", "country": "United States", "facility": "Cedars-Sinai Medical Center" }, { "city": "Oakland", "country": "United States", "facility": "Kaiser Permanente-Oakland" }, { "city": "Roseville", "country": "United States", "facility": "Kaiser Permanente-Roseville" }, { "city": "Sacramento", "country": "United States", "facility": "University of California Davis Comprehensive Cancer Center" }, { "city": "San Francisco", "country": "United States", "facility": "UCSF Medical Center-Parnassus" }, { "city": "San Mateo", "country": "United States", "facility": "Mills Health Center" }, { "city": "Santa Clara", "country": "United States", "facility": "Kaiser Permanente Medical Center - Santa Clara" }, { "city": "New Haven", "country": "United States", "facility": "Yale University" }, { "city": "Jacksonville", "country": "United States", "facility": "Mayo Clinic in Florida" }, { "city": "Miami", "country": "United States", "facility": "Miami Cancer Institute" }, { "city": "Pembroke Pines", "country": "United States", "facility": "Memorial Hospital West" }, { "city": "Albany", "country": "United States", "facility": "Phoebe Putney Memorial Hospital" }, { "city": "Augusta", "country": "United States", "facility": "Augusta University Medical Center" }, { "city": "Honolulu", "country": "United States", "facility": "Hawaii Cancer Care Inc - Waterfront Plaza" }, { "city": "Honolulu", "country": "United States", "facility": "Straub Clinic and Hospital" }, { "city": "Honolulu", "country": "United States", "facility": "Kapiolani Medical Center for Women and Children" }, { "city": "‘Aiea", "country": "United States", "facility": "Hawaii Cancer Care - Westridge" }, { "city": "‘Aiea", "country": "United States", "facility": "Pali Momi Medical Center" }, { "city": "Boise", "country": "United States", "facility": "Saint Alphonsus Cancer Care Center-Boise" }, { "city": "Boise", "country": "United States", "facility": "Saint Luke's Cancer Institute - Boise" }, { "city": "Caldwell", "country": "United States", "facility": "Saint Alphonsus Cancer Care Center-Caldwell" }, { "city": "Coeur d'Alene", "country": "United States", "facility": "Kootenai Health - Coeur d'Alene" }, { "city": "Fruitland", "country": "United States", "facility": "Saint Luke's Cancer Institute - Fruitland" }, { "city": "Meridian", "country": "United States", "facility": "Saint Luke's Cancer Institute - Meridian" }, { "city": "Nampa", "country": "United States", "facility": "Saint Alphonsus Cancer Care Center-Nampa" }, { "city": "Nampa", "country": "United States", "facility": "Saint Luke's Cancer Institute - Nampa" }, { "city": "Post Falls", "country": "United States", "facility": "Kootenai Clinic Cancer Services - Post Falls" }, { "city": "Sandpoint", "country": "United States", "facility": "Kootenai Clinic Cancer Services - Sandpoint" }, { "city": "Bloomington", "country": "United States", "facility": "OSF Saint Joseph Medical Center" }, { "city": "Bloomington", "country": "United States", "facility": "Illinois CancerCare-Bloomington" }, { "city": "Canton", "country": "United States", "facility": "Illinois CancerCare-Canton" }, { "city": "Carthage", "country": "United States", "facility": "Illinois CancerCare-Carthage" }, { "city": "Chicago", "country": "United States", "facility": "Northwestern University" }, { "city": "Chicago", "country": "United States", "facility": "University of Chicago Comprehensive Cancer Center" }, { "city": "Decatur", "country": "United States", "facility": "Cancer Care Specialists of Illinois - Decatur" }, { "city": "Decatur", "country": "United States", "facility": "Decatur Memorial Hospital" }, { "city": "Dixon", "country": "United States", "facility": "Illinois CancerCare-Dixon" }, { "city": "Effingham", "country": "United States", "facility": "Crossroads Cancer Center" }, { "city": "Eureka", "country": "United States", "facility": "Illinois CancerCare-Eureka" }, { "city": "Evanston", "country": "United States", "facility": "NorthShore University HealthSystem-Evanston Hospital" }, { "city": "Galesburg", "country": "United States", "facility": "Illinois CancerCare-Galesburg" }, { "city": "Glenview", "country": "United States", "facility": "NorthShore University HealthSystem-Glenbrook Hospital" }, { "city": "Highland Park", "country": "United States", "facility": "NorthShore University HealthSystem-Highland Park Hospital" }, { "city": "Kewanee", "country": "United States", "facility": "Illinois CancerCare-Kewanee Clinic" }, { "city": "Macomb", "country": "United States", "facility": "Illinois CancerCare-Macomb" }, { "city": "Maywood", "country": "United States", "facility": "Loyola University Medical Center" }, { "city": "New Lenox", "country": "United States", "facility": "UC Comprehensive Cancer Center at Silver Cross" }, { "city": "O'Fallon", "country": "United States", "facility": "Cancer Care Center of O'Fallon" }, { "city": "Orland Park", "country": "United States", "facility": "University of Chicago Medicine-Orland Park" }, { "city": "Ottawa", "country": "United States", "facility": "Illinois CancerCare-Ottawa Clinic" }, { "city": "Pekin", "country": "United States", "facility": "Illinois CancerCare-Pekin" }, { "city": "Peoria", "country": "United States", "facility": "Illinois CancerCare-Peoria" }, { "city": "Peoria", "country": "United States", "facility": "Methodist Medical Center of Illinois" }, { "city": "Peoria", "country": "United States", "facility": "OSF Saint Francis Medical Center" }, { "city": "Peru", "country": "United States", "facility": "Illinois CancerCare-Peru" }, { "city": "Princeton", "country": "United States", "facility": "Illinois CancerCare-Princeton" }, { "city": "Springfield", "country": "United States", "facility": "Southern Illinois University School of Medicine" }, { "city": "Springfield", "country": "United States", "facility": "Springfield Clinic" }, { "city": "Springfield", "country": "United States", "facility": "Springfield Memorial Hospital" }, { "city": "Washington", "country": "United States", "facility": "Illinois CancerCare - Washington" }, { "city": "Crown Point", "country": "United States", "facility": "UChicago Medicine Northwest Indiana" }, { "city": "Indianapolis", "country": "United States", "facility": "Indiana University/Melvin and Bren Simon Cancer Center" }, { "city": "Iowa City", "country": "United States", "facility": "University of Iowa/Holden Comprehensive Cancer Center" }, { "city": "Fairway", "country": "United States", "facility": "University of Kansas Clinical Research Center" }, { "city": "Kansas City", "country": "United States", "facility": "University of Kansas Cancer Center" }, { "city": "Overland Park", "country": "United States", "facility": "University of Kansas Hospital-Indian Creek Campus" }, { "city": "Westwood", "country": "United States", "facility": "University of Kansas Hospital-Westwood Cancer Center" }, { "city": "Lexington", "country": "United States", "facility": "University of Kentucky/Markey Cancer Center" }, { "city": "Louisville", "country": "United States", "facility": "The James Graham Brown Cancer Center at University of Louisville" }, { "city": "Louisville", "country": "United States", "facility": "UofL Health Medical Center Northeast" }, { "city": "Baton Rouge", "country": "United States", "facility": "LSU Health Baton Rouge-North Clinic" }, { "city": "Baton Rouge", "country": "United States", "facility": "Our Lady of the Lake Physician Group" }, { "city": "Baton Rouge", "country": "United States", "facility": "Our Lady of The Lake" }, { "city": "Portland", "country": "United States", "facility": "MaineHealth Maine Medical Center - Portland" }, { "city": "Scarborough", "country": "United States", "facility": "MaineHealth Maine Medical Center- Scarborough" }, { "city": "South Portland", "country": "United States", "facility": "MaineHealth Cancer Care and IV Therapy - South Portland" }, { "city": "Baltimore", "country": "United States", "facility": "Johns Hopkins University/Sidney Kimmel Cancer Center" }, { "city": "Bethesda", "country": "United States", "facility": "Walter Reed National Military Medical Center" }, { "city": "Boston", "country": "United States", "facility": "Tufts Medical Center" }, { "city": "Boston", "country": "United States", "facility": "Beth Israel Deaconess Medical Center" }, { "city": "Boston", "country": "United States", "facility": "Dana-Farber Cancer Institute" }, { "city": "Burlington", "country": "United States", "facility": "Lahey Clinic" }, { "city": "Peabody", "country": "United States", "facility": "Lahey Clinic Peabody" }, { "city": "Ann Arbor", "country": "United States", "facility": "Trinity Health Saint Joseph Mercy Hospital Ann Arbor" }, { "city": "Brighton", "country": "United States", "facility": "Trinity Health IHA Medical Group Hematology Oncology - Brighton" }, { "city": "Canton", "country": "United States", "facility": "Trinity Health IHA Medical Group Hematology Oncology - Canton" }, { "city": "Chelsea", "country": "United States", "facility": "Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital" }, { "city": "Clinton Township", "country": "United States", "facility": "Henry Ford Macomb Hospital-Clinton Township" }, { "city": "Detroit", "country": "United States", "facility": "Wayne State University/Karmanos Cancer Institute" }, { "city": "Detroit", "country": "United States", "facility": "Henry Ford Hospital" }, { "city": "Farmington Hills", "country": "United States", "facility": "Weisberg Cancer Treatment Center" }, { "city": "Flint", "country": "United States", "facility": "Cancer Hematology Centers - Flint" }, { "city": "Flint", "country": "United States", "facility": "Genesee Hematology Oncology PC" }, { "city": "Flint", "country": "United States", "facility": "Genesys Hurley Cancer Institute" }, { "city": "Flint", "country": "United States", "facility": "Hurley Medical Center" }, { "city": "Jackson", "country": "United States", "facility": "Allegiance Health" }, { "city": "Livonia", "country": "United States", "facility": "Trinity Health Saint Mary Mercy Livonia Hospital" }, { "city": "Novi", "country": "United States", "facility": "Henry Ford Medical Center-Columbus" }, { "city": "Pontiac", "country": "United States", "facility": "Trinity Health Saint Joseph Mercy Oakland Hospital" }, { "city": "West Bloomfield", "country": "United States", "facility": "Henry Ford West Bloomfield Hospital" }, { "city": "Ypsilanti", "country": "United States", "facility": "Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus" }, { "city": "Coon Rapids", "country": "United States", "facility": "Mercy Hospital" }, { "city": "Deer River", "country": "United States", "facility": "Essentia Health - Deer River Clinic" }, { "city": "Duluth", "country": "United States", "facility": "Essentia Health Cancer Center" }, { "city": "Edina", "country": "United States", "facility": "Fairview Southdale Hospital" }, { "city": "Edina", "country": "United States", "facility": "Minnesota Oncology - Edina" }, { "city": "Hibbing", "country": "United States", "facility": "Essentia Health Hibbing Clinic" }, { "city": "Minneapolis", "country": "United States", "facility": "Abbott-Northwestern Hospital" }, { "city": "Rochester", "country": "United States", "facility": "Mayo Clinic in Rochester" }, { "city": "Saint Louis Park", "country": "United States", "facility": "Park Nicollet Clinic - Saint Louis Park" }, { "city": "Saint Paul", "country": "United States", "facility": "Regions Hospital" }, { "city": "Saint Paul", "country": "United States", "facility": "United Hospital" }, { "city": "Sandstone", "country": "United States", "facility": "Essentia Health Sandstone" }, { "city": "Virginia", "country": "United States", "facility": "Essentia Health Virginia Clinic" }, { "city": "Columbus", "country": "United States", "facility": "Baptist Memorial Hospital and Cancer Center-Golden Triangle" }, { "city": "Grenada", "country": "United States", "facility": "Baptist Cancer Center-Grenada" }, { "city": "New Albany", "country": "United States", "facility": "Baptist Memorial Hospital and Cancer Center-Union County" }, { "city": "Oxford", "country": "United States", "facility": "Baptist Memorial Hospital and Cancer Center-Oxford" }, { "city": "Southhaven", "country": "United States", "facility": "Baptist Memorial Hospital and Cancer Center-Desoto" }, { "city": "City of Saint Peters", "country": "United States", "facility": "Siteman Cancer Center at Saint Peters Hospital" }, { "city": "Creve Coeur", "country": "United States", "facility": "Siteman Cancer Center at West County Hospital" }, { "city": "St Louis", "country": "United States", "facility": "Washington University School of Medicine" }, { "city": "St Louis", "country": "United States", "facility": "Siteman Cancer Center-South County" }, { "city": "St Louis", "country": "United States", "facility": "Siteman Cancer Center at Christian Hospital" }, { "city": "Anaconda", "country": "United States", "facility": "Community Hospital of Anaconda" }, { "city": "Billings", "country": "United States", "facility": "Billings Clinic Cancer Center" }, { "city": "Bozeman", "country": "United States", "facility": "Bozeman Health Deaconess Hospital" }, { "city": "Great Falls", "country": "United States", "facility": "Benefis Sletten Cancer Institute" }, { "city": "Kalispell", "country": "United States", "facility": "Logan Health Medical Center" }, { "city": "Missoula", "country": "United States", "facility": "Community Medical Center" }, { "city": "Bellevue", "country": "United States", "facility": "Nebraska Medicine-Bellevue" }, { "city": "Omaha", "country": "United States", "facility": "Nebraska Medicine-Village Pointe" }, { "city": "Omaha", "country": "United States", "facility": "University of Nebraska Medical Center" }, { "city": "Las Vegas", "country": "United States", "facility": "OptumCare Cancer Care at Charleston" }, { "city": "Las Vegas", "country": "United States", "facility": "OptumCare Cancer Care at Fort Apache" }, { "city": "Basking Ridge", "country": "United States", "facility": "Memorial Sloan Kettering Basking Ridge" }, { "city": "Camden", "country": "United States", "facility": "Cooper Hospital University Medical Center" }, { "city": "Livingston", "country": "United States", "facility": "Cooperman Barnabas Medical Center" }, { "city": "Long Branch", "country": "United States", "facility": "Monmouth Medical Center" }, { "city": "Middletown", "country": "United States", "facility": "Memorial Sloan Kettering Monmouth" }, { "city": "Montvale", "country": "United States", "facility": "Memorial Sloan Kettering Bergen" }, { "city": "New Brunswick", "country": "United States", "facility": "Rutgers Cancer Institute of New Jersey" }, { "city": "Paramus", "country": "United States", "facility": "The Valley Hospital - Luckow Pavilion" }, { "city": "Ridgewood", "country": "United States", "facility": "Valley Health System Ridgewood Campus" }, { "city": "Toms River", "country": "United States", "facility": "Community Medical Center" }, { "city": "Albuquerque", "country": "United States", "facility": "University of New Mexico Cancer Center" }, { "city": "Buffalo", "country": "United States", "facility": "Roswell Park Cancer Institute" }, { "city": "Commack", "country": "United States", "facility": "Memorial Sloan Kettering Commack" }, { "city": "Harrison", "country": "United States", "facility": "Memorial Sloan Kettering Westchester" }, { "city": "Lake Success", "country": "United States", "facility": "Northwell Health/Center for Advanced Medicine" }, { "city": "Manhasset", "country": "United States", "facility": "North Shore University Hospital" }, { "city": "New York", "country": "United States", "facility": "Mount Sinai Hospital" }, { "city": "New York", "country": "United States", "facility": "Memorial Sloan Kettering Cancer Center" }, { "city": "Rochester", "country": "United States", "facility": "University of Rochester" }, { "city": "Stony Brook", "country": "United States", "facility": "Stony Brook University Medical Center" }, { "city": "Syracuse", "country": "United States", "facility": "State University of New York Upstate Medical University" }, { "city": "The Bronx", "country": "United States", "facility": "Montefiore Medical Center - Moses Campus" }, { "city": "Uniondale", "country": "United States", "facility": "Memorial Sloan Kettering Nassau" }, { "city": "Charlotte", "country": "United States", "facility": "Carolinas Medical Center/Levine Cancer Institute" }, { "city": "Durham", "country": "United States", "facility": "Duke University Medical Center" }, { "city": "Greenville", "country": "United States", "facility": "East Carolina University" }, { "city": "Winston-Salem", "country": "United States", "facility": "Wake Forest University Health Sciences" }, { "city": "Cleveland", "country": "United States", "facility": "Case Western Reserve University" }, { "city": "Columbus", "country": "United States", "facility": "Ohio State University Comprehensive Cancer Center" }, { "city": "Oklahoma City", "country": "United States", "facility": "University of Oklahoma Health Sciences Center" }, { "city": "Ontario", "country": "United States", "facility": "Saint Alphonsus Cancer Care Center-Ontario" }, { "city": "Portland", "country": "United States", "facility": "Providence Portland Medical Center" }, { "city": "Portland", "country": "United States", "facility": "Providence Saint Vincent Medical Center" }, { "city": "Portland", "country": "United States", "facility": "Oregon Health and Science University" }, { "city": "Allentown", "country": "United States", "facility": "Lehigh Valley Hospital-Cedar Crest" }, { "city": "Danville", "country": "United States", "facility": "Geisinger Medical Center" }, { "city": "Hershey", "country": "United States", "facility": "Penn State Milton S Hershey Medical Center" }, { "city": "Lewistown", "country": "United States", "facility": "Lewistown Hospital" }, { "city": "Philadelphia", "country": "United States", "facility": "University of Pennsylvania/Abramson Cancer Center" }, { "city": "Philadelphia", "country": "United States", "facility": "Thomas Jefferson University Hospital" }, { "city": "Pittsburgh", "country": "United States", "facility": "UPMC Hillman Cancer Center" }, { "city": "West Reading", "country": "United States", "facility": "Reading Hospital" }, { "city": "Wilkes-Barre", "country": "United States", "facility": "Geisinger Wyoming Valley/Henry Cancer Center" }, { "city": "Providence", "country": "United States", "facility": "Rhode Island Hospital" }, { "city": "Boiling Springs", "country": "United States", "facility": "Prisma Health Cancer Institute - Spartanburg" }, { "city": "Charleston", "country": "United States", "facility": "Medical University of South Carolina" }, { "city": "Easley", "country": "United States", "facility": "Prisma Health Cancer Institute - Easley" }, { "city": "Greenville", "country": "United States", "facility": "Prisma Health Cancer Institute - Butternut" }, { "city": "Greenville", "country": "United States", "facility": "Prisma Health Cancer Institute - Faris" }, { "city": "Greenville", "country": "United States", "facility": "Prisma Health Cancer Institute - Eastside" }, { "city": "Greer", "country": "United States", "facility": "Prisma Health Cancer Institute - Greer" }, { "city": "Seneca", "country": "United States", "facility": "Prisma Health Cancer Institute - Seneca" }, { "city": "Collierville", "country": "United States", "facility": "Baptist Memorial Hospital and Cancer Center-Collierville" }, { "city": "Knoxville", "country": "United States", "facility": "University of Tennessee - Knoxville" }, { "city": "Memphis", "country": "United States", "facility": "Baptist Memorial Hospital and Cancer Center-Memphis" }, { "city": "Salt Lake City", "country": "United States", "facility": "Huntsman Cancer Institute/University of Utah" }, { "city": "Burlington", "country": "United States", "facility": "University of Vermont Medical Center" }, { "city": "Burlington", "country": "United States", "facility": "University of Vermont and State Agricultural College" }, { "city": "Charlottesville", "country": "United States", "facility": "University of Virginia Cancer Center" }, { "city": "Fairfax", "country": "United States", "facility": "Inova Schar Cancer Institute" }, { "city": "Falls Church", "country": "United States", "facility": "Inova Fairfax Hospital" }, { "city": "Edmonds", "country": "United States", "facility": "Swedish Cancer Institute-Edmonds" }, { "city": "Issaquah", "country": "United States", "facility": "Swedish Cancer Institute-Issaquah" }, { "city": "Seattle", "country": "United States", "facility": "Swedish Medical Center-First Hill" }, { "city": "Appleton", "country": "United States", "facility": "ThedaCare Regional Cancer Center" }, { "city": "Appleton", "country": "United States", "facility": "ThedaCare Regional Medical Center - Appleton" }, { "city": "Ashland", "country": "United States", "facility": "Duluth Clinic Ashland" }, { "city": "Green Bay", "country": "United States", "facility": "Saint Vincent Hospital Cancer Center Green Bay" }, { "city": "Green Bay", "country": "United States", "facility": "Saint Vincent Hospital Cancer Center at Saint Mary's" }, { "city": "La Crosse", "country": "United States", "facility": "Gundersen Lutheran Medical Center" }, { "city": "Madison", "country": "United States", "facility": "University of Wisconsin Carbone Cancer Center - Eastpark Medical Center" }, { "city": "Madison", "country": "United States", "facility": "University of Wisconsin Carbone Cancer Center - University Hospital" }, { "city": "Milwaukee", "country": "United States", "facility": "Medical College of Wisconsin" }, { "city": "Stevens Point", "country": "United States", "facility": "Marshfield Medical Center-River Region at Stevens Point" }, { "city": "Weston", "country": "United States", "facility": "Marshfield Medical Center - Weston" }, { "city": "Calgary", "country": "Canada", "facility": "Arthur J E Child Comprehensive Cancer Centre" }, { "city": "Edmonton", "country": "Canada", "facility": "University of Alberta Hospital" }, { "city": "Winnipeg", "country": "Canada", "facility": "CancerCare Manitoba" }, { "city": "Halifax", "country": "Canada", "facility": "QEII Health Sciences Centre/Nova Scotia Health Authority" }, { "city": "Ottawa", "country": "Canada", "facility": "Ottawa Hospital and Cancer Center-General Campus" }, { "city": "Toronto", "country": "Canada", "facility": "University Health Network-Princess Margaret Hospital" }, { "city": "Greenfield Park", "country": "Canada", "facility": "CSSS Champlain-Charles Le Moyne" }, { "city": "Montreal", "country": "Canada", "facility": "CIUSSSEMTL-Hopital Maisonneuve-Rosemont" }, { "city": "Montreal", "country": "Canada", "facility": "Jewish General Hospital" }, { "city": "San Juan", "country": "Puerto Rico", "facility": "Centro Comprensivo de Cancer de UPR" }, { "city": "San Juan", "country": "Puerto Rico", "facility": "San Juan City Hospital" } ], "outcomes": { "other": [], "primary": [ "Minimal residual disease (MRD) response (Arm 1, 2, 4 and 5)", "MRD response (Arm 3)" ], "secondary": [ "Early mortality", "Time to count recovery", "Event-free survival", "Relapse-free survival", "Overall survival", "Time to relapse", "MRD negative complete remission (MRDneg CR)", "Incidence of adverse events" ] }, "eligibility": { "sex": "ALL", "criteria": "Inclusion Criteria:\n\n* STEP 1 REGISTRATION:\n* Participants must have been registered to Master Screening and Re-Assessment Protocol, MYELOMATCH, prior to consenting to this study. Participants must have been assigned to this clinical trial, via MATCHBox, prior to registration to this study.\n\n * Note: Pre-enrollment/diagnosis labs must have already been performed under MYELOMATCH\n* Participants must have newly diagnosed, untreated acute myeloid leukemia (AML) per World Health Organization (WHO) criteria\n* Participants must have high-risk (adverse) AML per European LeukemiaNet (ELN) 2017 criteria\n* Participants with therapy-related AML (t-AML), or with AML evolving from an antecedent hematologic disorder (such as myeloproliferative neoplasm), or AML with myelodysplasia-related changes (AML-MRC) are eligible-unless they were previously treated\n* Acute promyelocytic leukemia is excluded\n* Participants with favorable or intermediate risk disease per ELN 2017 criteria are excluded\n* Participants with FLT3 mutations (ITD or TKD) are excluded\n* Participants with t(9;22) translocation are excluded\n* A single dose of intrathecal chemotherapy for AML is allowed prior to study entry\n* Prior anthracycline therapy for any indication is allowed but must not exceed a cumulative lifetime dose of 200 mg/m\\^2 daunorubicin or equivalent\n* Participants must not have received or be currently receiving any prior therapy for acute myeloid leukemia. Hydroxyurea to control the white blood cells (WBC) is allowed prior to registration and initiation of protocol-defined therapy. All trans retinoic acid (ATRA) given until a diagnosis of acute promyelocytic leukemia is ruled out is also allowed. For urgent cytoreduction, cytarabine may be given either as a single dose or in multiple doses not to exceed 2500 mg\n* Participants must not be receiving or planning to receive any other investigational agents before completing protocol therapy\n* Participants must be between 18 and 59 years of age\n* Participants must have Zubrod performance status =\\< 3 as determined by a complete medical history and physical exam (H\\&P) completed within 7 days prior to registration\n* Participants must be able to swallow and retain oral medications and have no known gastrointestinal disorders likely to interfere with absorption of oral medications\n* Participants with a known history of human immunodeficiency virus (HIV)-infection must be on effective anti-retroviral therapy at time of registration and have undetectable HIV viral load on the most recent test results obtained within 6 months prior to registration\n* Participants with a known history of chronic hepatitis B virus (HBV) infection must have undetectable HBV viral load within 28 days prior to registration and be on suppressive therapy, if indicated\n* Participants with a known history of hepatitis C virus (HCV) infection must have been treated and cured. Participants with active HCV infection who are currently on treatment must have an undetectable HCV viral load within 28 days prior to registration\n* The following tests must be performed within 14 days prior to registration to establish baseline values:\n\n * Complete blood count (CBC)/differential/platelets\n * Total bilirubin\n * Lactate dehydrogenase (LDH)\n * Albumin\n * Glucose\n * Fibrinogen\n* Participants must have adequate kidney function as evidenced by creatinine clearance \\>= 30mL/min (by Cockcroft Gault) within 7 days prior to registration\n* Participants must have adequate liver function as evidenced by aspartate aminotransferase (AST) and alanine aminotransferase (ALT) ≤ 3.0 x upper limit of normal (ULN) within 7 days prior to registration- unless elevations are considered due to leukemia in the opinion of the treating investigator\n* Total bilirubin =\\< 2.0 x ULN (or 5.0 x ULN if the participant has a history of Gilbert's disease) within 28 days prior to registration\n* Participants must have adequate cardiac function as determined by echocardiography or MUGA scan with an ejection fraction \\>= 50% within 28 days prior to registration\n* Participants with a prior or concurrent malignancy whose natural history (in the opinion of the treating physician) does not have the potential to interfere with the safety or efficacy assessment of the investigational regimen are eligible for this trial. No concurrent therapies for such malignancy are allowed with the exception of hormonal therapy\n* Participants with central nervous system (CNS) disease are eligible for this trial and will be treated according to institutional guidelines with intrathecal chemotherapy for this aspect of their disease.\n* Participants with known history of Wilson's disease or other known copper-metabolism disorder are excluded\n* Participants must not be pregnant or nursing. Women/men of reproductive potential must have agreed to use 2 contraception methods. A woman is considered to be of \"reproductive potential\" if she has had menses at any time in the preceding 12 consecutive months. In addition to routine contraceptive methods (e.g., hormonal contraceptives \\[examples include birth control pills, vaginal rings, or patches\\] associated with inhibition of ovulation for at least 1 month prior to taking study drug), \"effective contraception\" also includes heterosexual celibacy and surgery intended to prevent pregnancy (or with a side-effect of pregnancy prevention) defined as a hysterectomy, bilateral oophorectomy or bilateral tubal ligation. However, if at any point a previously celibate participant chooses to become heterosexually active during the time period for use of contraceptive measures outlined in the protocol, he/she is responsible for beginning contraceptive measures. A barrier method should be used during this study along with hormonal contraceptives from initial study drug administration to 30 days after the last dose of study drug as drug-drug interaction with venetoclax is unknown\n* Participants must have agreed to have specimens submitted for translational medicine (MRD) under MYELOMATCH and specimens must be submitted\n* Participants must be offered the opportunity to participate in specimen banking\n\n * Note: Specimens must be collected and submitted using the Southwest Oncology Group (SWOG) Specimen Tracking System\n* Participants must be informed of the investigational nature of this study and must sign and give informed consent in accordance with institutional and federal guidelines\n\n * For participants with impaired decision-making capabilities, legally authorized representatives may sign and give informed consent on behalf of study participants in accordance with applicable federal, local, and Central Institutional Review Board (CIRB) regulations\n* As a part of the Oncology Patient Enrollment Network (OPEN) registration process the treating institution's identity is provided in order to ensure that the current (within 365 days) date of institutional review board approval for this study has been entered in the system", "maximumAge": "59 Years", "minimumAge": "18 Years", "healthyVolunteers": false }, "enrollment": { "type": "ESTIMATED", "count": 335 }, "startDate": "2024-09-25", "completionDate": "2027-03-31", "lastUpdated": "2026-10-27T00:00:00.000Z", "firstPosted": "2022-09-26T00:00:00.000Z", "resultsAvailable": false, "sourceRegistries": [ "clinicaltrials_gov" ], "sourceUrls": [ "https://clinicaltrials.gov/study/NCT05554406" ] }, "identifiers": [ { "idType": "nct", "idValue": "NCT05554406", "declaredBy": "clinicaltrials_gov" } ], "sourceRecords": [ { "registry": "clinicaltrials_gov", "registryName": "ClinicalTrials.gov", "license": "public-domain", "sourceId": "NCT05554406", "sourceUrl": "https://clinicaltrials.gov/study/NCT05554406", "sourceStatus": "RECRUITING", "retrievedAt": "2026-10-28T04:33:27.159Z", "payloadSha256": "b59a3447409618842498744bafad6232a7282edfa85b2dc868065068655f37c6", "piiRedacted": true } ], "citation": { "canonicalId": "NCT05554406", "sources": [ { "registry": "clinicaltrials_gov", "registryName": "ClinicalTrials.gov", "license": "public-domain", "sourceId": "NCT05554406", "verifyAt": "https://clinicaltrials.gov/study/NCT05554406", "retrievedAt": "2026-10-28T04:33:27.159Z", "payloadSha256": "b59a3447409618842498744bafad6232a7282edfa85b2dc868065068655f37c6", "text": "ClinicalTrials.gov, record NCT05554406 (https://clinicaltrials.gov/study/NCT05554406), retrieved 2026-10-28, licence: public-domain." } ], "crossRegistry": false, "dedupMethod": "exact cross-registry identifier matching; probabilistic = review only", "text": "Trial NCT05554406, registered in ClinicalTrials.gov, retrieved 2026-10-28. 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