{ "data": { "asOf": "2026-10-30T22:24:36.395Z", "dedupMethod": "exact cross-registry identifier matching; probabilistic = review only", "byRegistry": { "clinicaltrials_gov": 1 }, "canonicalTrial": { "canonicalId": "NCT05554393", "title": "Comparing Cytarabine + Daunorubicin Therapy Versus Cytarabine + Daunorubicin + Venetoclax Versus Venetoclax + Azacitidine in Younger Patients With Intermediate Risk AML (A MyeloMATCH Treatment Trial)", "scientificTitle": "A Measurable Residual Disease (MRD) Focused, Phase II Study of Venetoclax Plus Chemotherapy for Newly Diagnosed Younger Patients With Intermediate Risk Acute Myeloid Leukemia: A Tier 1 MYELOMATCH SubStudy", "status": "recruiting", "studyType": "interventional", "phase": [ "PHASE2" ], "conditions": [ "Acute Myeloid Leukemia" ], "interventions": [ { "name": "Azacitidine", "type": "DRUG", "description": "Given IV or SC" }, { "name": "Biospecimen Collection", "type": "PROCEDURE", "description": "Undergo collection of blood samples" }, { "name": "Bone Marrow Aspiration", "type": "PROCEDURE", "description": "Undergo bone marrow aspiration" }, { "name": "Cytarabine", "type": "DRUG", "description": "Given IV" }, { "name": "Daunorubicin Hydrochloride", "type": "DRUG", "description": "Given IV" }, { "name": "Echocardiography Test", "type": "PROCEDURE", "description": "Undergo ECHO" }, { "name": "Multigated Acquisition Scan", "type": "PROCEDURE", "description": "Undergo MUGA" }, { "name": "Venetoclax", "type": "DRUG", "description": "Given PO" } ], "sponsor": { "name": "National Cancer Institute (NCI)", "type": "NIH" }, "locations": [ { "city": "Birmingham", "country": "United States", "facility": "University of Alabama at Birmingham Cancer Center" }, { "city": "Tucson", "country": "United States", "facility": "Banner University Medical Center - Tucson" }, { "city": "Tucson", "country": "United States", "facility": "University of Arizona Cancer Center-North Campus" }, { "city": "Little Rock", "country": "United States", "facility": "University of Arkansas for Medical Sciences" }, { "city": "Berkeley", "country": "United States", "facility": "Alta Bates Summit Medical Center-Herrick Campus" }, { "city": "Los Angeles", "country": "United States", "facility": "Cedars-Sinai Medical Center" }, { "city": "Oakland", "country": "United States", "facility": "Kaiser Permanente-Oakland" }, { "city": "Roseville", "country": "United States", "facility": "Kaiser Permanente-Roseville" }, { "city": "San Francisco", "country": "United States", "facility": "UCSF Medical Center-Parnassus" }, { "city": "Santa Clara", "country": "United States", "facility": "Kaiser Permanente Medical Center - Santa Clara" }, { "city": "New Haven", "country": "United States", "facility": "Yale University" }, { "city": "Miami", "country": "United States", "facility": "Miami Cancer Institute" }, { "city": "Pembroke Pines", "country": "United States", "facility": "Memorial Hospital West" }, { "city": "Albany", "country": "United States", "facility": "Phoebe Putney Memorial Hospital" }, { "city": "Boise", "country": "United States", "facility": "Saint Alphonsus Cancer Care Center-Boise" }, { "city": "Boise", "country": "United States", "facility": "Saint Luke's Cancer Institute - Boise" }, { "city": "Caldwell", "country": "United States", "facility": "Saint Alphonsus Cancer Care Center-Caldwell" }, { "city": "Coeur d'Alene", "country": "United States", "facility": "Kootenai Health - Coeur d'Alene" }, { "city": "Fruitland", "country": "United States", "facility": "Saint Luke's Cancer Institute - Fruitland" }, { "city": "Meridian", "country": "United States", "facility": "Saint Luke's Cancer Institute - Meridian" }, { "city": "Nampa", "country": "United States", "facility": "Saint Alphonsus Cancer Care Center-Nampa" }, { "city": "Nampa", "country": "United States", "facility": "Saint Luke's Cancer Institute - Nampa" }, { "city": "Post Falls", "country": "United States", "facility": "Kootenai Clinic Cancer Services - Post Falls" }, { "city": "Sandpoint", "country": "United States", "facility": "Kootenai Clinic Cancer Services - Sandpoint" }, { "city": "Centralia", "country": "United States", "facility": "Centralia Oncology Clinic" }, { "city": "Chicago", "country": "United States", "facility": "Northwestern University" }, { "city": "Chicago", "country": "United States", "facility": "University of Chicago Comprehensive Cancer Center" }, { "city": "Decatur", "country": "United States", "facility": "Cancer Care Specialists of Illinois - Decatur" }, { "city": "Decatur", "country": "United States", "facility": "Decatur Memorial Hospital" }, { "city": "Effingham", "country": "United States", "facility": "Crossroads Cancer Center" }, { "city": "Evanston", "country": "United States", "facility": "NorthShore University HealthSystem-Evanston Hospital" }, { "city": "Glenview", "country": "United States", "facility": "NorthShore University HealthSystem-Glenbrook Hospital" }, { "city": "Highland Park", "country": "United States", "facility": "NorthShore University HealthSystem-Highland Park Hospital" }, { "city": "Maywood", "country": "United States", "facility": "Loyola University Medical Center" }, { "city": "New Lenox", "country": "United States", "facility": "UC Comprehensive Cancer Center at Silver Cross" }, { "city": "O'Fallon", "country": "United States", "facility": "Cancer Care Center of O'Fallon" }, { "city": "Orland Park", "country": "United States", "facility": "University of Chicago Medicine-Orland Park" }, { "city": "Springfield", "country": "United States", "facility": "Southern Illinois University School of Medicine" }, { "city": "Springfield", "country": "United States", "facility": "Springfield Clinic" }, { "city": "Springfield", "country": "United States", "facility": "Springfield Memorial Hospital" }, { "city": "Crown Point", "country": "United States", "facility": "UChicago Medicine Northwest Indiana" }, { "city": "Iowa City", "country": "United States", "facility": "University of Iowa/Holden Comprehensive Cancer Center" }, { "city": "Fairway", "country": "United States", "facility": "University of Kansas Clinical Research Center" }, { "city": "Kansas City", "country": "United States", "facility": "University of Kansas Cancer Center" }, { "city": "Overland Park", "country": "United States", "facility": "University of Kansas Hospital-Indian Creek Campus" }, { "city": "Westwood", "country": "United States", "facility": "University of Kansas Hospital-Westwood Cancer Center" }, { "city": "Lexington", "country": "United States", "facility": "University of Kentucky/Markey Cancer Center" }, { "city": "Louisville", "country": "United States", "facility": "The James Graham Brown Cancer Center at University of Louisville" }, { "city": "Louisville", "country": "United States", "facility": "UofL Health Medical Center Northeast" }, { "city": "Baton Rouge", "country": "United States", "facility": "LSU Health Baton Rouge-North Clinic" }, { "city": "Baton Rouge", "country": "United States", "facility": "Our Lady of the Lake Physician Group" }, { "city": "Baton Rouge", "country": "United States", "facility": "Our Lady of The Lake" }, { "city": "Portland", "country": "United States", "facility": "MaineHealth Maine Medical Center - Portland" }, { "city": "Scarborough", "country": "United States", "facility": "MaineHealth Maine Medical Center- Scarborough" }, { "city": "South Portland", "country": "United States", "facility": "MaineHealth Cancer Care and IV Therapy - South Portland" }, { "city": "Bethesda", "country": "United States", "facility": "Walter Reed National Military Medical Center" }, { "city": "Boston", "country": "United States", "facility": "Tufts Medical Center" }, { "city": "Boston", "country": "United States", "facility": "Dana-Farber Cancer Institute" }, { "city": "Burlington", "country": "United States", "facility": "Lahey Clinic" }, { "city": "Peabody", "country": "United States", "facility": "Lahey Clinic Peabody" }, { "city": "Brighton", "country": "United States", "facility": "Trinity Health IHA Medical Group Hematology Oncology - Brighton" }, { "city": "Canton", "country": "United States", "facility": "Trinity Health IHA Medical Group Hematology Oncology - Canton" }, { "city": "Chelsea", "country": "United States", "facility": "Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital" }, { "city": "Clinton Township", "country": "United States", "facility": "Henry Ford Macomb Hospital-Clinton Township" }, { "city": "Detroit", "country": "United States", "facility": "Henry Ford Hospital" }, { "city": "Flint", "country": "United States", "facility": "Cancer Hematology Centers - Flint" }, { "city": "Flint", "country": "United States", "facility": "Genesee Hematology Oncology PC" }, { "city": "Flint", "country": "United States", "facility": "Genesys Hurley Cancer Institute" }, { "city": "Flint", "country": "United States", "facility": "Hurley Medical Center" }, { "city": "Jackson", "country": "United States", "facility": "Allegiance Health" }, { "city": "Livonia", "country": "United States", "facility": "Trinity Health Saint Mary Mercy Livonia Hospital" }, { "city": "Novi", "country": "United States", "facility": "Henry Ford Medical Center-Columbus" }, { "city": "Pontiac", "country": "United States", "facility": "Trinity Health Saint Joseph Mercy Oakland Hospital" }, { "city": "West Bloomfield", "country": "United States", "facility": "Henry Ford West Bloomfield Hospital" }, { "city": "Ypsilanti", "country": "United States", "facility": "Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus" }, { "city": "Coon Rapids", "country": "United States", "facility": "Mercy Hospital" }, { "city": "Deer River", "country": "United States", "facility": "Essentia Health - Deer River Clinic" }, { "city": "Duluth", "country": "United States", "facility": "Essentia Health Cancer Center" }, { "city": "Edina", "country": "United States", "facility": "Fairview Southdale Hospital" }, { "city": "Edina", "country": "United States", "facility": "Minnesota Oncology - Edina" }, { "city": "Hibbing", "country": "United States", "facility": "Essentia Health Hibbing Clinic" }, { "city": "Minneapolis", "country": "United States", "facility": "Abbott-Northwestern Hospital" }, { "city": "Saint Louis Park", "country": "United States", "facility": "Park Nicollet Clinic - Saint Louis Park" }, { "city": "Saint Paul", "country": "United States", "facility": "Regions Hospital" }, { "city": "Saint Paul", "country": "United States", "facility": "United Hospital" }, { "city": "Sandstone", "country": "United States", "facility": "Essentia Health Sandstone" }, { "city": "Virginia", "country": "United States", "facility": "Essentia Health Virginia Clinic" }, { "city": "Columbus", "country": "United States", "facility": "Baptist Memorial Hospital and Cancer Center-Golden Triangle" }, { "city": "Grenada", "country": "United States", "facility": "Baptist Cancer Center-Grenada" }, { "city": "New Albany", "country": "United States", "facility": "Baptist Memorial Hospital and Cancer Center-Union County" }, { "city": "Oxford", "country": "United States", "facility": "Baptist Memorial Hospital and Cancer Center-Oxford" }, { "city": "Southhaven", "country": "United States", "facility": "Baptist Memorial Hospital and Cancer Center-Desoto" }, { "city": "City of Saint Peters", "country": "United States", "facility": "Siteman Cancer Center at Saint Peters Hospital" }, { "city": "Creve Coeur", "country": "United States", "facility": "Siteman Cancer Center at West County Hospital" }, { "city": "St Louis", "country": "United States", "facility": "Washington University School of Medicine" }, { "city": "St Louis", "country": "United States", "facility": "Siteman Cancer Center-South County" }, { "city": "St Louis", "country": "United States", "facility": "Siteman Cancer Center at Christian Hospital" }, { "city": "Anaconda", "country": "United States", "facility": "Community Hospital of Anaconda" }, { "city": "Billings", "country": "United States", "facility": "Billings Clinic Cancer Center" }, { "city": "Bozeman", "country": "United States", "facility": "Bozeman Health Deaconess Hospital" }, { "city": "Great Falls", "country": "United States", "facility": "Benefis Sletten Cancer Institute" }, { "city": "Kalispell", "country": "United States", "facility": "Logan Health Medical Center" }, { "city": "Missoula", "country": "United States", "facility": "Community Medical Center" }, { "city": "Bellevue", "country": "United States", "facility": "Nebraska Medicine-Bellevue" }, { "city": "Omaha", "country": "United States", "facility": "Nebraska Medicine-Village Pointe" }, { "city": "Omaha", "country": "United States", "facility": "University of Nebraska Medical Center" }, { "city": "Las Vegas", "country": "United States", "facility": "OptumCare Cancer Care at Charleston" }, { "city": "Las Vegas", "country": "United States", "facility": "OptumCare Cancer Care at Fort Apache" }, { "city": "Lebanon", "country": "United States", "facility": "Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center" }, { "city": "Basking Ridge", "country": "United States", "facility": "Memorial Sloan Kettering Basking Ridge" }, { "city": "Livingston", "country": "United States", "facility": "Cooperman Barnabas Medical Center" }, { "city": "Long Branch", "country": "United States", "facility": "Monmouth Medical Center" }, { "city": "Middletown", "country": "United States", "facility": "Memorial Sloan Kettering Monmouth" }, { "city": "Montvale", "country": "United States", "facility": "Memorial Sloan Kettering Bergen" }, { "city": "New Brunswick", "country": "United States", "facility": "Rutgers Cancer Institute of New Jersey" }, { "city": "Paramus", "country": "United States", "facility": "The Valley Hospital - Luckow Pavilion" }, { "city": "Ridgewood", "country": "United States", "facility": "Valley Health System Ridgewood Campus" }, { "city": "Toms River", "country": "United States", "facility": "Community Medical Center" }, { "city": "Albuquerque", "country": "United States", "facility": "University of New Mexico Cancer Center" }, { "city": "Buffalo", "country": "United States", "facility": "Roswell Park Cancer Institute" }, { "city": "Commack", "country": "United States", "facility": "Memorial Sloan Kettering Commack" }, { "city": "New York", "country": "United States", "facility": "Mount Sinai Hospital" }, { "city": "New York", "country": "United States", "facility": "Memorial Sloan Kettering Cancer Center" }, { "city": "Rochester", "country": "United States", "facility": "University of Rochester" }, { "city": "Stony Brook", "country": "United States", "facility": "Stony Brook University Medical Center" }, { "city": "The Bronx", "country": "United States", "facility": "Montefiore Medical Center - Moses Campus" }, { "city": "Uniondale", "country": "United States", "facility": "Memorial Sloan Kettering Nassau" }, { "city": "Charlotte", "country": "United States", "facility": "Carolinas Medical Center/Levine Cancer Institute" }, { "city": "Charlotte", "country": "United States", "facility": "Novant Health Presbyterian Medical Center" }, { "city": "Durham", "country": "United States", "facility": "Duke University Medical Center" }, { "city": "Greenville", "country": "United States", "facility": "East Carolina University" }, { "city": "Winston-Salem", "country": "United States", "facility": "Novant Health Forsyth Medical Center" }, { "city": "Winston-Salem", "country": "United States", "facility": "Wake Forest University Health Sciences" }, { "city": "Cleveland", "country": "United States", "facility": "Case Western Reserve University" }, { "city": "Oklahoma City", "country": "United States", "facility": "University of Oklahoma Health Sciences Center" }, { "city": "Ontario", "country": "United States", "facility": "Saint Alphonsus Cancer Care Center-Ontario" }, { "city": "Portland", "country": "United States", "facility": "Providence Portland Medical Center" }, { "city": "Portland", "country": "United States", "facility": "Providence Saint Vincent Medical Center" }, { "city": "Allentown", "country": "United States", "facility": "Lehigh Valley Hospital-Cedar Crest" }, { "city": "Danville", "country": "United States", "facility": "Geisinger Medical Center" }, { "city": "Hershey", "country": "United States", "facility": "Penn State Milton S Hershey Medical Center" }, { "city": "Lewistown", "country": "United States", "facility": "Lewistown Hospital" }, { "city": "Pittsburgh", "country": "United States", "facility": "UPMC Hillman Cancer Center" }, { "city": "West Reading", "country": "United States", "facility": "Reading Hospital" }, { "city": "Wilkes-Barre", "country": "United States", "facility": "Geisinger Wyoming Valley/Henry Cancer Center" }, { "city": "Providence", "country": "United States", "facility": "Rhode Island Hospital" }, { "city": "Boiling Springs", "country": "United States", "facility": "Prisma Health Cancer Institute - Spartanburg" }, { "city": "Easley", "country": "United States", "facility": "Prisma Health Cancer Institute - Easley" }, { "city": "Greenville", "country": "United States", "facility": "Prisma Health Cancer Institute - Butternut" }, { "city": "Greenville", "country": "United States", "facility": "Prisma Health Cancer Institute - Faris" }, { "city": "Greenville", "country": "United States", "facility": "Prisma Health Cancer Institute - Eastside" }, { "city": "Greer", "country": "United States", "facility": "Prisma Health Cancer Institute - Greer" }, { "city": "Seneca", "country": "United States", "facility": "Prisma Health Cancer Institute - Seneca" }, { "city": "Collierville", "country": "United States", "facility": "Baptist Memorial Hospital and Cancer Center-Collierville" }, { "city": "Knoxville", "country": "United States", "facility": "University of Tennessee - Knoxville" }, { "city": "Memphis", "country": "United States", "facility": "Baptist Memorial Hospital and Cancer Center-Memphis" }, { "city": "Houston", "country": "United States", "facility": "Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center" }, { "city": "Houston", "country": "United States", "facility": "Ben Taub General Hospital" }, { "city": "Salt Lake City", "country": "United States", "facility": "Huntsman Cancer Institute/University of Utah" }, { "city": "Burlington", "country": "United States", "facility": "University of Vermont Medical Center" }, { "city": "Burlington", "country": "United States", "facility": "University of Vermont and State Agricultural College" }, { "city": "Charlottesville", "country": "United States", "facility": "University of Virginia Cancer Center" }, { "city": "Fairfax", "country": "United States", "facility": "Inova Schar Cancer Institute" }, { "city": "Falls Church", "country": "United States", "facility": "Inova Fairfax Hospital" }, { "city": "Edmonds", "country": "United States", "facility": "Swedish Cancer Institute-Edmonds" }, { "city": "Issaquah", "country": "United States", "facility": "Swedish Cancer Institute-Issaquah" }, { "city": "Seattle", "country": "United States", "facility": "Swedish Medical Center-First Hill" }, { "city": "Appleton", "country": "United States", "facility": "ThedaCare Regional Cancer Center" }, { "city": "Appleton", "country": "United States", "facility": "ThedaCare Regional Medical Center - Appleton" }, { "city": "Ashland", "country": "United States", "facility": "Duluth Clinic Ashland" }, { "city": "Green Bay", "country": "United States", "facility": "Saint Vincent Hospital Cancer Center Green Bay" }, { "city": "Green Bay", "country": "United States", "facility": "Saint Vincent Hospital Cancer Center at Saint Mary's" }, { "city": "La Crosse", "country": "United States", "facility": "Gundersen Lutheran Medical Center" }, { "city": "Milwaukee", "country": "United States", "facility": "Medical College of Wisconsin" }, { "city": "Stevens Point", "country": "United States", "facility": "Marshfield Medical Center-River Region at Stevens Point" }, { "city": "Weston", "country": "United States", "facility": "Marshfield Medical Center - Weston" }, { "city": "Calgary", "country": "Canada", "facility": "Arthur J E Child Comprehensive Cancer Centre" }, { "city": "Edmonton", "country": "Canada", "facility": "University of Alberta Hospital" }, { "city": "Winnipeg", "country": "Canada", "facility": "CancerCare Manitoba" }, { "city": "Halifax", "country": "Canada", "facility": "QEII Health Sciences Centre/Nova Scotia Health Authority" }, { "city": "Hamilton", "country": "Canada", "facility": "Juravinski Cancer Centre at Hamilton Health Sciences" }, { "city": "Toronto", "country": "Canada", "facility": "Odette Cancer Centre- Sunnybrook Health Sciences Centre" }, { "city": "Greenfield Park", "country": "Canada", "facility": "CSSS Champlain-Charles Le Moyne" }, { "city": "Montreal", "country": "Canada", "facility": "CIUSSSEMTL-Hopital Maisonneuve-Rosemont" }, { "city": "Montreal", "country": "Canada", "facility": "Jewish General Hospital" }, { "city": "San Juan", "country": "Puerto Rico", "facility": "Centro Comprensivo de Cancer de UPR" }, { "city": "San Juan", "country": "Puerto Rico", "facility": "San Juan City Hospital" } ], "outcomes": { "other": [ "Comparative analysis by molecular characteristics" ], "primary": [ "Measurable residual disease (MRD) undetectable complete remission (CR)" ], "secondary": [ "Frequency and severity of toxicities with each of the regimens", "CR rates", "Complete remission with incomplete count recovery (CRi)", "Event-free survival", "Relapse-free survival", "Overall survival", "Responses to therapy received relative to genomic findings" ] }, "eligibility": { "sex": "ALL", "criteria": "Inclusion Criteria:\n\n* Participants must have been registered to master screening and re-assessment protocol (MYELOMATCH) prior to consenting to this study. Participants must have been assigned to this clinical trial, via MATCHBox Protocol Assignment Team, prior to registration to this study. Participants must have agreed to have specimens submitted for translational medicine and must be offered the opportunity to submit biosamples for banking for future research as per MYELOMATCH\n\n * Note: Pre-enrollment/diagnosis labs must have already been performed under MYELOMATCH\n* Previously untreated, de novo acute myeloid leukemia (AML) defined by \\>= 20% myeloblasts in the peripheral blood or bone marrow (as defined by the current World Health Organization \\[WHO\\] classification of myeloid neoplasms and acute leukemia) excluding all the following categories of AML:\n\n * Favorable cytogenetics: (t(8;21)q22;q22.1); RUNX1-RUNX1T1, inversion 16(p13.1;q22), t(16;16)(p13.1;q22); CBFB-MYH11\n * CEBPA biallelic mutations\n * NPM1 mutation\n * AML with PML-RARalpha\n * AML with any adverse cytogenetics, TP53 mutation, RUNX1 mutation, ASXL1, 11q23/KMT2 rearrangements\n * AML with FLT3-ITD mutation\n * Therapy related AML, or AML following a diagnosis of myelodysplasia or myeloproliferative neoplasm Participants with central nervous system (CNS) disease are eligible for this trial and will be treated according to institutional guidelines with intrathecal chemotherapy for this aspect of their disease\n* Age 18-59 years at time of induction therapy\n* Eastern Cooperative Oncology Group (ECOG) performance status =\\< 3\n* Total bilirubin =\\< 2 x institutional upper limit of normal (ULN) (must be done within 10 days of enrollment)\n* Aspartate aminotransferase (AST) (serum glutamate pyruvate transaminase \\[SGPT\\]) and/or alanine aminotransferase (ALT) (serum glutamic-oxaloacetic transaminase \\[SGOT\\]) =\\< 3 × institutional ULN (must be done within 10 days of enrollment)\n* Cardiac ejection fraction \\>= 50% (echocardiography or MUGA) (if clinically indicated must be done within 14 days of enrollment)\n* Calculated creatinine clearance \\>= 30 mL/min; Clearance to be calculated using Cockcroft formula (must be done within 10 days of enrollment)\n* White blood cells (WBC) must be =\\< 25 x 10\\^9/L. Hydroxyurea and leukapheresis are permitted to control the WBC prior to enrollment and initiation of protocol-defined therapy but must be stopped prior to the initiation of protocol therapy. Hydroxyurea +/- no more than a total of 2500 mg cytarabine over a total of multiple days for urgent cytoreduction is also permitted\n* Patients with a prior or concurrent malignancy whose natural history or treatment does not have the potential to interfere with the safety or efficacy assessment of the investigational regimen are eligible for this trial\n* Patients with known history or current symptoms of cardiac disease, or history of treatment with cardiotoxic agents, should have a clinical risk assessment of cardiac function using the New York Heart Association Functional Classification. To be eligible for this trial, patients should be class 2B or better\n* Males and females of reproductive potential must have agreed to use a highly effective contraceptive method while on treatment and for 6 months after stopping study drug. A woman is considered to be of \"childbearing potential\" if she has had menses at any time in the preceding 12 consecutive months. In addition to routine contraceptive methods, \"effective contraception\" also includes heterosexual celibacy and surgery intended to prevent pregnancy (or with a side-effect of pregnancy prevention) defined as a hysterectomy, bilateral oophorectomy or bilateral tubal ligation, or vasectomy/vasectomized partner. However, if at any point a previously celibate patient chooses to become heterosexually active during the time period for use of contraceptive measures outlined in the protocol, he/she is responsible for beginning contraceptive measures.\n\nWomen of childbearing potential will have a pregnancy test to determine eligibility as part of the pre-study evaluation; this may include an ultrasound to rule-out pregnancy if a false-positive is suspected. Patient will be considered eligible if an ultrasound is negative for pregnancy\n\n* Patient consent must be appropriately obtained in accordance with applicable local and regulatory requirements. Each patient must sign a consent form prior to enrollment in the trial to document their willingness to participate\n* Patients must be accessible for treatment, response assessment and follow up. Patients enrolled on this trial must be treated and followed at the participating centre. Investigators must assure themselves the patients enrolled on this trial will be available for complete documentation of the treatment, adverse events, and follow-up.\n\nPatients must agree to return to their primary care facility for any adverse events which may occur through the course of the trial\n\n* In accordance with Canadian Cancer Trials Group (CCTG) policy, protocol treatment is to begin within 7 working days of patient enrollment\n* Patients with known human immunodeficiency virus (HIV) infection who are on effective anti-retroviral therapy and have undetectable viral load within 6 months of enrollment are eligible for this trial\n* Participants with evidence of chronic hepatitis B virus (HBV) infection must have undetectable HBV viral load within 28 days of enrollment. Patients need to be on suppressive therapy, if indicated\n* Patients with a history of hepatitis C virus (HCV) infection who have been treated and cured are eligible. Patients who with active HCV infection who are currently being treated must have an undetectable HCV viral load within 28 days of enrollment to be eligible\n\nExclusion Criteria:\n\n* Prior therapy for AML except for hydroxyurea and leukapheresis to control blood counts. The use of all-trans retinoic acid (ATRA) is permitted until a diagnosis of acute promyelocytic leukemia, if suspected, is ruled out\n* Patients who are receiving any other investigational agents\n* History of allergic reactions attributed to compounds of similar chemical or biologic composition to cytarabine, daunorubicin, azacitidine, venetoclax\n* Pregnant women are excluded from this study because venetoclax, cytarabine and azacitidine have the potential for teratogenic or abortifacient effects. Because there is an unknown but potential risk for adverse events in nursing infants secondary to treatment of the mother with venetoclax, cytarabine and azacitidine breastfeeding should be discontinued if the mother is treated with venetoclax, cytarabine and azacitidine. 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