{
  "data": {
    "asOf": "2026-10-30T22:26:37.514Z",
    "dedupMethod": "exact cross-registry identifier matching; probabilistic = review only",
    "byRegistry": {
      "clinicaltrials_gov": 1
    },
    "canonicalTrial": {
      "canonicalId": "NCT05531565",
      "title": "A 2-Part Study to Learn Whether Litifilimab (BIIB059) Injections Can Improve Symptoms of Adult Participants Who Have Active Cutaneous Lupus Erythematosus",
      "scientificTitle": "A 2-Part Seamless Part A (Phase 2)/Part B (Phase 3) Randomized, Double-Blind, Placebo-Controlled, Multicenter Study to Evaluate the Efficacy and Safety of BIIB059 in Participants With Active Subacute Cutaneous Lupus Erythematosus and/or Chronic Cutaneous Lupus Erythematosus With or Without Systemic Manifestations and Refractory and/or Intolerant to Antimalarial Therapy (AMETHYST)",
      "status": "active",
      "studyType": "interventional",
      "phase": [
        "PHASE2",
        "PHASE3"
      ],
      "conditions": [
        "Subacute Cutaneous Lupus Erythematosus",
        "Chronic Cutaneous Lupus Erythematosus"
      ],
      "interventions": [
        {
          "name": "Litifilimab",
          "type": "DRUG",
          "description": "Administered as specified in the treatment arm."
        },
        {
          "name": "Placebo",
          "type": "DRUG",
          "description": "Administered as specified in the treatment arm."
        }
      ],
      "sponsor": {
        "name": "Biogen",
        "type": "INDUSTRY"
      },
      "locations": [
        {
          "city": "Anniston",
          "country": "United States",
          "facility": "Pinnacle Research Group, LLC"
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        {
          "city": "Birmingham",
          "country": "United States",
          "facility": "UAB Center for Women's Reproductive Health"
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        {
          "city": "Phoenix",
          "country": "United States",
          "facility": "Arizona Arthritis & Rheumatology Research, PLLC"
        },
        {
          "city": "La Jolla",
          "country": "United States",
          "facility": "The Regents of the University of California"
        },
        {
          "city": "Los Angeles",
          "country": "United States",
          "facility": "Dermatology Research Associates"
        },
        {
          "city": "Santa Monica",
          "country": "United States",
          "facility": "Clinical Science Institute"
        },
        {
          "city": "Upland",
          "country": "United States",
          "facility": "Inland Rheumatology Clinical Trials, Inc."
        },
        {
          "city": "Denver",
          "country": "United States",
          "facility": "Denver Arthritis Clinic"
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        {
          "city": "DeBary",
          "country": "United States",
          "facility": "Omega Research Debary, LLC"
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        {
          "city": "Fort Lauderdale",
          "country": "United States",
          "facility": "Centre for Rheumatology, Immunology and Arthritis"
        },
        {
          "city": "Gainesville",
          "country": "United States",
          "facility": "University of Florida"
        },
        {
          "city": "Miami",
          "country": "United States",
          "facility": "University of Miami Miller School of Medicine"
        },
        {
          "city": "Miami",
          "country": "United States",
          "facility": "Millennium Medical Research, LLC"
        },
        {
          "city": "Miami",
          "country": "United States",
          "facility": "Medical Research Center of Miami"
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        {
          "city": "Miami",
          "country": "United States",
          "facility": "Diverse Clinical Research LLC"
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        {
          "city": "Miami Lakes",
          "country": "United States",
          "facility": "Charisma Medical and Research Center"
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        {
          "city": "Plantation",
          "country": "United States",
          "facility": "Leading Edge Dermatology"
        },
        {
          "city": "Augusta",
          "country": "United States",
          "facility": "Augusta University"
        },
        {
          "city": "Chicago",
          "country": "United States",
          "facility": "Rush University Medical Center"
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        {
          "city": "Rockford",
          "country": "United States",
          "facility": "OrthoIllinois"
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        {
          "city": "Indianapolis",
          "country": "United States",
          "facility": "Dawes Fretzin Clinical Research Group, LLC"
        },
        {
          "city": "Bowling Green",
          "country": "United States",
          "facility": "Equity Medical"
        },
        {
          "city": "New Orleans",
          "country": "United States",
          "facility": "LSU Health Sciences Center Shreveport"
        },
        {
          "city": "Boston",
          "country": "United States",
          "facility": "Tufts Medical Center"
        },
        {
          "city": "Boston",
          "country": "United States",
          "facility": "Brigham And Women's Hospital"
        },
        {
          "city": "Natick",
          "country": "United States",
          "facility": "Essential Dermatology"
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        {
          "city": "Quincy",
          "country": "United States",
          "facility": "Beacon Clinical Research, LLC"
        },
        {
          "city": "Worcester",
          "country": "United States",
          "facility": "University of Massachusetts, Worcester"
        },
        {
          "city": "Ann Arbor",
          "country": "United States",
          "facility": "David Fivenson, MD, Dermatology, PLLC"
        },
        {
          "city": "Auburn Hills",
          "country": "United States",
          "facility": "Oakland Hills Dermatology"
        },
        {
          "city": "Flint",
          "country": "United States",
          "facility": "AA MRC LLC Ahmed Arif Medical Research Center"
        },
        {
          "city": "Troy",
          "country": "United States",
          "facility": "Revival Research Institute, LLC"
        },
        {
          "city": "St Louis",
          "country": "United States",
          "facility": "Saint Louis University"
        },
        {
          "city": "Omaha",
          "country": "United States",
          "facility": "University of Nebraska Medical Center"
        },
        {
          "city": "Albuquerque",
          "country": "United States",
          "facility": "Albuquerque Center For Rheumatology"
        },
        {
          "city": "Albuquerque",
          "country": "United States",
          "facility": "University of New Mexico School of Medicine"
        },
        {
          "city": "Brooklyn",
          "country": "United States",
          "facility": "NYU Langone Brooklyn"
        },
        {
          "city": "Fairport",
          "country": "United States",
          "facility": "Universal Dermatology, PLLC"
        },
        {
          "city": "Great Neck",
          "country": "United States",
          "facility": "Northwell Health, Inc. PRIME"
        },
        {
          "city": "New York",
          "country": "United States",
          "facility": "Columbia University Medical center"
        },
        {
          "city": "Staten Island",
          "country": "United States",
          "facility": "Hawthorne Health"
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        {
          "city": "Chapel Hill",
          "country": "United States",
          "facility": "University of North Carolina at Chapel Hill"
        },
        {
          "city": "Durham",
          "country": "United States",
          "facility": "Duke Dermatology South Durham"
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        {
          "city": "Greensboro",
          "country": "United States",
          "facility": "Medication Management, LLC"
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        {
          "city": "Cincinnati",
          "country": "United States",
          "facility": "University of Cincinnati Department of Dermatology"
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        {
          "city": "Cleveland",
          "country": "United States",
          "facility": "University Hospitals Cleveland Medical Center"
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        {
          "city": "Columbus",
          "country": "United States",
          "facility": "Ohio State University"
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        {
          "city": "Hershey",
          "country": "United States",
          "facility": "Penn State University Milton S. Hershey Medical Center"
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          "city": "Philadelphia",
          "country": "United States",
          "facility": "University of Pennsylvania"
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        {
          "city": "Nashville",
          "country": "United States",
          "facility": "Vanderbilt University Medical Center"
        },
        {
          "city": "Austin",
          "country": "United States",
          "facility": "Austin Regional Clinic, P.A."
        },
        {
          "city": "Colleyville",
          "country": "United States",
          "facility": "Precision Comprehensive Clinical Research Solutions"
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          "city": "Dallas",
          "country": "United States",
          "facility": "Metroplex Clinical Research Center, LLC"
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        {
          "city": "Dallas",
          "country": "United States",
          "facility": "UT Southwestern Medical Center"
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        {
          "city": "Frisco",
          "country": "United States",
          "facility": "North Texas Center for Clinical Research"
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        {
          "city": "Galveston",
          "country": "United States",
          "facility": "UTMB Department of Dermatology"
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          "city": "Houston",
          "country": "United States",
          "facility": "University of Texas Health Science Center at Houston"
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        {
          "city": "Waco",
          "country": "United States",
          "facility": "Arthritis & Osteoporosis Clinic"
        },
        {
          "city": "Waco",
          "country": "United States",
          "facility": "Velocity Clinical Research Waco"
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        {
          "city": "Salt Lake City",
          "country": "United States",
          "facility": "University of Utah Health Sciences Center"
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        {
          "city": "Blacksburg",
          "country": "United States",
          "facility": "Open Door Clinical Research"
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        {
          "city": "Richmond",
          "country": "United States",
          "facility": "West End Dermatology Associates"
        },
        {
          "city": "CABA",
          "country": "Argentina",
          "facility": "CINME - Centro De Investigaciones Metabolicas"
        },
        {
          "city": "Mar del Plata",
          "country": "Argentina",
          "facility": "Centro de Investigaciones Medicas Mar del Plata"
        },
        {
          "city": "Quilmes",
          "country": "Argentina",
          "facility": "Instituto de Investigaciones Clinicas Quilmes"
        },
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          "city": "San Miguel",
          "country": "Argentina",
          "facility": "Centro de Investigaciones San Miguel"
        },
        {
          "city": "Buenos Aires",
          "country": "Argentina",
          "facility": "APRILLUS Asistencia e Investigacion"
        },
        {
          "city": "Buenos Aires",
          "country": "Argentina",
          "facility": "Fundacion Respirar"
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          "city": "Villa Nueva",
          "country": "Argentina",
          "facility": "Consultorio Alto Dorrego"
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        {
          "city": "Rosario",
          "country": "Argentina",
          "facility": "Instituto CAICI"
        },
        {
          "city": "San Miguel de Tucumán",
          "country": "Argentina",
          "facility": "Clinica Mayo de Urgencias Medicas Cruz Blanca SRL"
        },
        {
          "city": "San Miguel de Tucumán",
          "country": "Argentina",
          "facility": "Centro de Investigaciones Medicas Tucuman"
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        {
          "city": "San Miguel de Tucumán",
          "country": "Argentina",
          "facility": "Investigaciones Clinicas Tucuman"
        },
        {
          "city": "Buenos Aires",
          "country": "Argentina",
          "facility": "Hospital Italiano de La Plata"
        },
        {
          "city": "Ciudad Autonoma Buenos Aires",
          "country": "Argentina",
          "facility": "Hospital Italiano de Buenos Aires"
        },
        {
          "city": "Ciudad Autonoma Buenos Aires",
          "country": "Argentina",
          "facility": "Centro Privado de Medicina Familiar - Mind Out Research"
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        {
          "city": "Ciudad Autonoma Buenos Aires",
          "country": "Argentina",
          "facility": "Clinica Adventista Belgrano"
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          "city": "Mendoza",
          "country": "Argentina",
          "facility": "Instituto de Reumatologia"
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        {
          "city": "San Juan",
          "country": "Argentina",
          "facility": "CER San Juan Centro Polivalente de Asistencia e Inv. Clinica"
        },
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          "city": "Leuven",
          "country": "Belgium",
          "facility": "UZ Leuven"
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        {
          "city": "Brussels",
          "country": "Belgium",
          "facility": "Cliniques Universitaires Saint-Luc"
        },
        {
          "city": "Ghent",
          "country": "Belgium",
          "facility": "Universitair Ziekenhuis Gent"
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        {
          "city": "Liège",
          "country": "Belgium",
          "facility": "Centre Hospitalier Universitaire de Liege"
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        {
          "city": "Fortaleza",
          "country": "Brazil",
          "facility": "Integrare Terapêutica"
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        {
          "city": "Fortaleza",
          "country": "Brazil",
          "facility": "HUWC - UFC - Hospital Universitário Walter Cantídio - Universidade Federal do Ceará"
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          "city": "Vitória",
          "country": "Brazil",
          "facility": "CEDOES - Diagnóstico e Pesquisa"
        },
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          "city": "Salvador",
          "country": "Brazil",
          "facility": "Clínica SER da Bahia"
        },
        {
          "city": "Brasília",
          "country": "Brazil",
          "facility": "L2IP - Instituto de Pesquisas Clínicas Ltda."
        },
        {
          "city": "Santo Ângelo",
          "country": "Brazil",
          "facility": "IPC MT Instituto de Pesquisas Clinicas do Mato Grosso"
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        {
          "city": "Belo Horizonte",
          "country": "Brazil",
          "facility": "Santa Casa de Misericordia de Belo Horizonte"
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          "city": "Belo Horizonte",
          "country": "Brazil",
          "facility": "Freire Pesquisa Clinica"
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        {
          "city": "Belo Horizonte",
          "country": "Brazil",
          "facility": "Clinica Pulsus"
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        {
          "city": "Juiz de Fora",
          "country": "Brazil",
          "facility": "CMiP - Centro Mineiro de Pesquisa"
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        {
          "city": "Rio de Janeiro",
          "country": "Brazil",
          "facility": "Instituto Brasil de Pesquisa Clínica-IBPCLIN S/A"
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        {
          "city": "Rio de Janeiro",
          "country": "Brazil",
          "facility": "IDERJ - Instituto de Dermatologia e Estética do Brasil Ltda"
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        {
          "city": "Lajeado",
          "country": "Brazil",
          "facility": "Hospital Bruno Born"
        },
        {
          "city": "Porto Alegre",
          "country": "Brazil",
          "facility": "Hospital de Clínicas de Porto Alegre"
        },
        {
          "city": "Porto Alegre",
          "country": "Brazil",
          "facility": "Nucleo de Pesquisa Clinica do Rio Grande do Sul"
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        {
          "city": "Porto Alegre",
          "country": "Brazil",
          "facility": "LMK Serviços Médicos S/S Ltda"
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        {
          "city": "Porto Alegre",
          "country": "Brazil",
          "facility": "Hospital Moinhos de Vento"
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        {
          "city": "Porto Velho",
          "country": "Brazil",
          "facility": "IPES - Instituto de Pesquisa e Educação em Saúde"
        },
        {
          "city": "São Bernardo do Campo",
          "country": "Brazil",
          "facility": "CEMEC - Centro Multidisciplinar de Estudos Clínicos"
        },
        {
          "city": "São Paulo",
          "country": "Brazil",
          "facility": "CEPIC - Centro Paulista de Investigação Clínica e Serviços Médicos"
        },
        {
          "city": "Valinhos",
          "country": "Brazil",
          "facility": "A2Z Clinical Centro Avancado de Pesquisa Clinica"
        },
        {
          "city": "São Paulo",
          "country": "Brazil",
          "facility": "RDSS Ricardo Diaz Scientific Solution"
        },
        {
          "city": "Sevlievo",
          "country": "Bulgaria",
          "facility": "DCC-1-Sevlievo EOOD"
        },
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          "city": "Haskovo",
          "country": "Bulgaria",
          "facility": "DCC 'Sveti Georgi' EOOD"
        },
        {
          "city": "Pleven",
          "country": "Bulgaria",
          "facility": "Medical center Medconsult Pleven OOD"
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          "city": "Pleven",
          "country": "Bulgaria",
          "facility": "UMHAT 'Dr. Georgi Stranski', EAD"
        },
        {
          "city": "Rousse",
          "country": "Bulgaria",
          "facility": "DCC 1 - Ruse, EOOD"
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        {
          "city": "Sofia",
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          "facility": "Ambulatory for Specialized Medical Help - skin and venereal diseases"
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        {
          "city": "Sofia",
          "country": "Bulgaria",
          "facility": "DCC 'Alexandrovska', EOOD"
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        {
          "city": "Sofia",
          "country": "Bulgaria",
          "facility": "DCC Focus 5 - MEOH OOD"
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          "city": "Sofia",
          "country": "Bulgaria",
          "facility": "Military Medical Academy - MHAT - Sofia"
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        {
          "city": "Calgary",
          "country": "Canada",
          "facility": "Laser Rejuvenation Clinics, Inc."
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        {
          "city": "Edmonton",
          "country": "Canada",
          "facility": "Laster Rejuvenation Clinics Edmonton D.T. Inc."
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        {
          "city": "Greater Sudbury",
          "country": "Canada",
          "facility": "Medicor Research Inc"
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        {
          "city": "Ottawa",
          "country": "Canada",
          "facility": "Dermatology Ottawa Research Centre"
        },
        {
          "city": "Sherbrooke",
          "country": "Canada",
          "facility": "DIEX Recherche Sherbrooke Inc."
        },
        {
          "city": "Las Condes",
          "country": "Chile",
          "facility": "Centro Medico SkinMed"
        },
        {
          "city": "Santiago",
          "country": "Chile",
          "facility": "Dermacross"
        },
        {
          "city": "Santiago",
          "country": "Chile",
          "facility": "BioMedica Research Group"
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        {
          "city": "Santiago",
          "country": "Chile",
          "facility": "CeCim Biocinetic"
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        {
          "city": "Santiago",
          "country": "Chile",
          "facility": "CIEC - Centro Internacional de Estudios Clínicos"
        },
        {
          "city": "Valdivia",
          "country": "Chile",
          "facility": "Clinical Research Chile SpA."
        },
        {
          "city": "Viña del Mar",
          "country": "Chile",
          "facility": "Centro de Investigacion de Enfermedades Respiratorias e Inmunologicas"
        },
        {
          "city": "Beijing",
          "country": "China",
          "facility": "Beijing Tongren Hospital, Capital Medical University"
        },
        {
          "city": "Beijing",
          "country": "China",
          "facility": "Peking Union Medical College Hospital"
        },
        {
          "city": "Chongqing",
          "country": "China",
          "facility": "The First Affiliated Hospital of Chongqing Medical University"
        },
        {
          "city": "Fuzhou",
          "country": "China",
          "facility": "The First Affiliated Hospital of Fujian Medical University"
        },
        {
          "city": "Dongguan",
          "country": "China",
          "facility": "Dongguan People's Hospital"
        },
        {
          "city": "Guangzhou",
          "country": "China",
          "facility": "Nanfang Hospital of Southern Medical University"
        },
        {
          "city": "Shenzhen",
          "country": "China",
          "facility": "Shenzhen Second People's Hospital"
        },
        {
          "city": "Zhongshan",
          "country": "China",
          "facility": "Zhongshan TCM Hospital"
        },
        {
          "city": "Guangzhou",
          "country": "China",
          "facility": "Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University"
        },
        {
          "city": "Nanyang",
          "country": "China",
          "facility": "Nanyang First People's Hospital"
        },
        {
          "city": "Zhengzhou",
          "country": "China",
          "facility": "Henan Provincial People's Hospital"
        },
        {
          "city": "Changsha",
          "country": "China",
          "facility": "Xiangya Hospital of Central South University"
        },
        {
          "city": "Changsha",
          "country": "China",
          "facility": "The second Xiangya Hospital of Central South University"
        },
        {
          "city": "Baotou",
          "country": "China",
          "facility": "The First Affiliated Hospital of Baotou Medical College"
        },
        {
          "city": "Nanjing",
          "country": "China",
          "facility": "Hospital for Skin Diseases, Chinese Academy of Medical Sciences"
        },
        {
          "city": "Zhenjiang",
          "country": "China",
          "facility": "Affiliated Hospital of Jiangsu University"
        },
        {
          "city": "Changchun",
          "country": "China",
          "facility": "The First Hospital of Jilin University"
        },
        {
          "city": "Jinan",
          "country": "China",
          "facility": "Qilu Hospital of Shandong University"
        },
        {
          "city": "Shanghai",
          "country": "China",
          "facility": "Ruijin Hospital of Shanghai Jiaotong University School of Medicine"
        },
        {
          "city": "Shanghai",
          "country": "China",
          "facility": "Zhongshan Hospital Fudan University"
        },
        {
          "city": "Shanghai",
          "country": "China",
          "facility": "Shanghai Skin Disease Hospital"
        },
        {
          "city": "Kunming",
          "country": "China",
          "facility": "The Second Affiliated Hospital of Kunming Medical University"
        },
        {
          "city": "Hangzhou",
          "country": "China",
          "facility": "The First Affiliated Hospital of Zhejiang University school of medicine"
        },
        {
          "city": "Hangzhou",
          "country": "China",
          "facility": "Hangzhou First People's Hospital"
        },
        {
          "city": "Hangzhou",
          "country": "China",
          "facility": "Zhejiang Provincial People's Hospital"
        },
        {
          "city": "Wenzhou",
          "country": "China",
          "facility": "The First Affiliated Hospital of Wenzhou Medical University"
        },
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          "city": "Barranquilla",
          "country": "Colombia",
          "facility": "Centro de Investigacion Medico Asistencial S.A.S"
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          "city": "Zipaquirá",
          "country": "Colombia",
          "facility": "Healthy Medical Center"
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        {
          "city": "Bucaramanga",
          "country": "Colombia",
          "facility": "Servimed S.A.S."
        },
        {
          "city": "Bogotá",
          "country": "Colombia",
          "facility": "Centro de Investigacion en Reumatologia y Especialidades Medicas SAS. CIREEM"
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        {
          "city": "Nice",
          "country": "France",
          "facility": "CHU Nice - Hopital de l Archet"
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        {
          "city": "Marseille",
          "country": "France",
          "facility": "Hôpital de la Timone"
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        {
          "city": "Caen",
          "country": "France",
          "facility": "CHU de Caen - Hopital de la Cote de Nacre"
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        {
          "city": "Besançon",
          "country": "France",
          "facility": "CHU Besançon - Hôpital Jean Minjoz"
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          "city": "Toulouse",
          "country": "France",
          "facility": "Hopital Larrey"
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        {
          "city": "Antony",
          "country": "France",
          "facility": "Hôpital Privé d'Antony"
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        {
          "city": "Montpellier",
          "country": "France",
          "facility": "Hopital Saint Eloi"
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        {
          "city": "Lille",
          "country": "France",
          "facility": "Hopital Claude Huriez - CHU Lille"
        },
        {
          "city": "Cedex 10",
          "country": "France",
          "facility": "Hôpital Saint-Louis"
        },
        {
          "city": "Lyon",
          "country": "France",
          "facility": "Hopital Edouard Herriot - CHU Lyon"
        },
        {
          "city": "Paris",
          "country": "France",
          "facility": "Hopital Tenon"
        },
        {
          "city": "Heidelberg",
          "country": "Germany",
          "facility": "Universitaetsklinikum Heidelberg"
        },
        {
          "city": "Tübingen",
          "country": "Germany",
          "facility": "Universitaetsklinikum Tuebingen"
        },
        {
          "city": "Erlangen",
          "country": "Germany",
          "facility": "Universitaetsklinikum Erlangen"
        },
        {
          "city": "Munich",
          "country": "Germany",
          "facility": "LMU-Campus Innenstadt"
        },
        {
          "city": "Munich",
          "country": "Germany",
          "facility": "Klinikum rechts der Isar der TU Muenchen"
        },
        {
          "city": "Regensburg",
          "country": "Germany",
          "facility": "Universitaetsklinikum Regensburg"
        },
        {
          "city": "Würzburg",
          "country": "Germany",
          "facility": "Universitaetsklinikum Wuerzburg"
        },
        {
          "city": "Bad Bentheim",
          "country": "Germany",
          "facility": "Fachklinik Bad Bentheim Dermatologie"
        },
        {
          "city": "Buxtehude",
          "country": "Germany",
          "facility": "Elbekliniken Buxtehude GmbH"
        },
        {
          "city": "Oldenburg",
          "country": "Germany",
          "facility": "Klinikum Oldenburg AoeR"
        },
        {
          "city": "Aachen",
          "country": "Germany",
          "facility": "Universitaetsklinikum Aachen AoeR"
        },
        {
          "city": "Bonn",
          "country": "Germany",
          "facility": "Universitaetsklinikum Bonn AoeR"
        },
        {
          "city": "Düsseldorf",
          "country": "Germany",
          "facility": "Universitaetsklinikum Duesseldorf AoeR"
        },
        {
          "city": "Münster",
          "country": "Germany",
          "facility": "Universitaetsklinikum Muenster"
        },
        {
          "city": "Dresden",
          "country": "Germany",
          "facility": "Universitaetsklinikum Carl Gustav Carus TU Dresden"
        },
        {
          "city": "Halle",
          "country": "Germany",
          "facility": "Universitaetsklinikum Halle (Saale)"
        },
        {
          "city": "Kiel",
          "country": "Germany",
          "facility": "Universitaetsklinikum Schleswig-Holstein - Campus Kiel"
        },
        {
          "city": "Berlin",
          "country": "Germany",
          "facility": "Charité - Campus Charité Mitte"
        },
        {
          "city": "Budapest",
          "country": "Hungary",
          "facility": "Semmelweis Egyetem"
        },
        {
          "city": "Pécs",
          "country": "Hungary",
          "facility": "Pecsi Tudomanyegyetem"
        },
        {
          "city": "Szeged",
          "country": "Hungary",
          "facility": "Szegedi Tudomanyegyetem Szent-Gyorgyi Albert Klinikai Kozpont"
        },
        {
          "city": "Bologna",
          "country": "Italy",
          "facility": "Azienda Ospedaliera Universitaria Policlinico Sant'Orsola Malpighi IRCCS"
        },
        {
          "city": "Brescia",
          "country": "Italy",
          "facility": "Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia (Presidio Spedali Civili)"
        },
        {
          "city": "Florence",
          "country": "Italy",
          "facility": "Università degli studi di Firenze"
        },
        {
          "city": "Genova",
          "country": "Italy",
          "facility": "IRCCS Ospedale Policlinico San Martino"
        },
        {
          "city": "Milan",
          "country": "Italy",
          "facility": "Fondazione IRCCS CA' Granda Ospedale Maggiore Policlinico"
        },
        {
          "city": "Milan",
          "country": "Italy",
          "facility": "Ospedale San Raffaele"
        },
        {
          "city": "Naples",
          "country": "Italy",
          "facility": "Azienda Ospedaliera Universitaria Policlinico 'Federico II'"
        },
        {
          "city": "Roma",
          "country": "Italy",
          "facility": "Fondazione Policlinico Universitario Agostino Gemelli IRCCS"
        },
        {
          "city": "Nagoya",
          "country": "Japan",
          "facility": "JCHO Chukyo Hospital"
        },
        {
          "city": "Nagoya",
          "country": "Japan",
          "facility": "NHO Nagoya Medical Center"
        },
        {
          "city": "Toyoake-shi",
          "country": "Japan",
          "facility": "Fujita Health University Hospital"
        },
        {
          "city": "Aomori",
          "country": "Japan",
          "facility": "Aomori Prefectural Central Hospital"
        },
        {
          "city": "Urayasu-shi",
          "country": "Japan",
          "facility": "Juntendo University Urayasu Hospital"
        },
        {
          "city": "Yoshida-gun",
          "country": "Japan",
          "facility": "University of Fukui Hospital"
        },
        {
          "city": "Kitakyushu-shi",
          "country": "Japan",
          "facility": "Hospital of the University of Occupational and Environmental Health"
        },
        {
          "city": "Sapporo",
          "country": "Japan",
          "facility": "Hokkaido University Hospital"
        },
        {
          "city": "Kakogawa-shi",
          "country": "Japan",
          "facility": "Kakogawa Central City Hospital"
        },
        {
          "city": "Ono-shi",
          "country": "Japan",
          "facility": "Kita Harima Medical Center"
        },
        {
          "city": "Kanazawa",
          "country": "Japan",
          "facility": "Kanazawa University Hospital"
        },
        {
          "city": "Kawasaki-shi",
          "country": "Japan",
          "facility": "St. Marianna University Hospital"
        },
        {
          "city": "Yokohama",
          "country": "Japan",
          "facility": "Yokohama City University Medical Center"
        },
        {
          "city": "Yokohama",
          "country": "Japan",
          "facility": "Yokohama City University Hospital"
        },
        {
          "city": "Yokohama",
          "country": "Japan",
          "facility": "NHO Yokohama Medical Center"
        },
        {
          "city": "Kumamoto",
          "country": "Japan",
          "facility": "Kumamoto University Hospital"
        },
        {
          "city": "Sendai",
          "country": "Japan",
          "facility": "Tohoku University Hospital"
        },
        {
          "city": "Nagasaki",
          "country": "Japan",
          "facility": "Nagasaki University Hospital"
        },
        {
          "city": "Niigata",
          "country": "Japan",
          "facility": "Niigata University Medical & Dental Hospital"
        },
        {
          "city": "Okayama",
          "country": "Japan",
          "facility": "Japanese Red Cross Okayama Hospital"
        },
        {
          "city": "Kawachinagano-shi",
          "country": "Japan",
          "facility": "NHO Osaka Minami Medical Center"
        },
        {
          "city": "Osaka",
          "country": "Japan",
          "facility": "Osaka Keisatsu Hospital"
        },
        {
          "city": "Osakasayama-shi",
          "country": "Japan",
          "facility": "Kindai University Hospital"
        },
        {
          "city": "Suita-shi",
          "country": "Japan",
          "facility": "Osaka University Hospital"
        },
        {
          "city": "Takatsuki-shi",
          "country": "Japan",
          "facility": "Takatsuki Red Cross Hospital"
        },
        {
          "city": "Ōtsu",
          "country": "Japan",
          "facility": "Shiga University of Medical Science Hospital"
        },
        {
          "city": "Izumo-shi",
          "country": "Japan",
          "facility": "Shimane University Hospital"
        },
        {
          "city": "Itabashi-ku",
          "country": "Japan",
          "facility": "Teikyo University Hospital"
        },
        {
          "city": "Shinagawa-ku",
          "country": "Japan",
          "facility": "Showa University East Hospital"
        },
        {
          "city": "Wakayama",
          "country": "Japan",
          "facility": "Wakayama Medical University Hospital"
        },
        {
          "city": "Guadalajara",
          "country": "Mexico",
          "facility": "Centro de investigacion medica y reumatologia"
        },
        {
          "city": "Mexico City",
          "country": "Mexico",
          "facility": "Centro de Investigacion Clínica GRAMEL S.C"
        },
        {
          "city": "Mexico City",
          "country": "Mexico",
          "facility": "Clinstile, S.A. de C.V."
        },
        {
          "city": "Cuernavaca",
          "country": "Mexico",
          "facility": "Consultorio Privado Dr. Miguel Cortes Hernandez"
        },
        {
          "city": "Mérida",
          "country": "Mexico",
          "facility": "Medical Care & Research SA de CV"
        },
        {
          "city": "Aguascalientes",
          "country": "Mexico",
          "facility": "Derma Norte del Bajio S.C."
        },
        {
          "city": "Chihuahua City",
          "country": "Mexico",
          "facility": "Investigacion y Biomedicina de Chihuahua, S.C."
        },
        {
          "city": "Lima",
          "country": "Peru",
          "facility": "ACQ MEDIC SAC - Centro de Investigacion Clinica Inmunoreumatologia"
        },
        {
          "city": "Lima",
          "country": "Peru",
          "facility": "Invest Clinicas Sac Inst de Ginecologia y Reproduccion"
        },
        {
          "city": "Mabalacat",
          "country": "Philippines",
          "facility": "The Medical City Clark"
        },
        {
          "city": "Cebu City",
          "country": "Philippines",
          "facility": "Cebu Doctors University Hospital"
        },
        {
          "city": "City of Taguig",
          "country": "Philippines",
          "facility": "Ospital Ng Makati"
        },
        {
          "city": "Lipa City",
          "country": "Philippines",
          "facility": "Mary Mediatrix Medical Center"
        },
        {
          "city": "Manila",
          "country": "Philippines",
          "facility": "Medical Center Manila"
        },
        {
          "city": "Manila",
          "country": "Philippines",
          "facility": "Philippine General Hospital"
        },
        {
          "city": "Manila",
          "country": "Philippines",
          "facility": "Jose R. Reyes Memorial Medical Center"
        },
        {
          "city": "Pasig",
          "country": "Philippines",
          "facility": "The Medical City"
        },
        {
          "city": "Quezon City",
          "country": "Philippines",
          "facility": "St. Luke's Medical Center"
        },
        {
          "city": "Quezon City, Metro Manila",
          "country": "Philippines",
          "facility": "Far Eastern University - Dr. Nicanor Reyes Medical Foundation"
        },
        {
          "city": "San Fenando, La Union",
          "country": "Philippines",
          "facility": "Ilocos Training and Regional Medical Center"
        },
        {
          "city": "San Fernando City, La Union",
          "country": "Philippines",
          "facility": "Lorma Medical Center"
        },
        {
          "city": "Kielce",
          "country": "Poland",
          "facility": "DERMEDIC Jacek Zdybski"
        },
        {
          "city": "Krakow",
          "country": "Poland",
          "facility": "SPZOZ Szpital Uniwersytecki w Krakowie"
        },
        {
          "city": "Krakow",
          "country": "Poland",
          "facility": "Promed P.Lach R.Glowacki spolka jawna, Centrum Medyczne PROMED"
        },
        {
          "city": "Krakow",
          "country": "Poland",
          "facility": "Specjalistyczny Gabinet Dermatologiczny Aplikacyjno-Badawczy Marek Brzewski"
        },
        {
          "city": "Krosno",
          "country": "Poland",
          "facility": "MT Medic Specjalistyczna Praktyka Lekarska Tomasz Stapinski"
        },
        {
          "city": "Lodz",
          "country": "Poland",
          "facility": "Dermoklinika Centrum Medyczne SC M Kierstan J Narbutt A Lesiak"
        },
        {
          "city": "Rzeszów",
          "country": "Poland",
          "facility": "Kliniczny Szpital Wojewodzki nr 1 im.F.Chopina"
        },
        {
          "city": "Warsaw",
          "country": "Poland",
          "facility": "MICS Centrum Medyczne Warszawa"
        },
        {
          "city": "Warsaw",
          "country": "Poland",
          "facility": "Szpital Kliniczny Dzieciatka Jezus"
        },
        {
          "city": "Warsaw",
          "country": "Poland",
          "facility": "Royalderm, Agnieszka Nawrocka"
        },
        {
          "city": "Wroclaw",
          "country": "Poland",
          "facility": "Cityclinic Przychodnia Lekarsko-Psychologiczna Matusiak Spółka Partnerska"
        },
        {
          "city": "Coimbra",
          "country": "Portugal",
          "facility": "Centro Hospitalar e Universitário de Coimbra, E.P.E (HUC)"
        },
        {
          "city": "Lisbon",
          "country": "Portugal",
          "facility": "Hospital de Egas Moniz"
        },
        {
          "city": "Lisbon",
          "country": "Portugal",
          "facility": "Hospital CUF Descobertas"
        },
        {
          "city": "Porto",
          "country": "Portugal",
          "facility": "Centro Hospitalar Universitártio do Porto, E.P.E."
        },
        {
          "city": "Viana do Castelo",
          "country": "Portugal",
          "facility": "Unidade Local de Saúde do Alto Minho, E.P.E."
        },
        {
          "city": "Caguas",
          "country": "Puerto Rico",
          "facility": "Dr. Samuel Sanchez PSC"
        },
        {
          "city": "San Juan",
          "country": "Puerto Rico",
          "facility": "GCM Medical Group PSC - Hato Rey"
        },
        {
          "city": "Riyadh",
          "country": "Saudi Arabia",
          "facility": "King Faisal Specialist Hospital & Research Center"
        },
        {
          "city": "Riyadh",
          "country": "Saudi Arabia",
          "facility": "King Saud University"
        },
        {
          "city": "Belgrade",
          "country": "Serbia",
          "facility": "Institute of Rheumatology"
        },
        {
          "city": "Belgrade",
          "country": "Serbia",
          "facility": "University Clinical Center of Serbia"
        },
        {
          "city": "Kragujevac",
          "country": "Serbia",
          "facility": "University Clinical Center Kragujevac"
        },
        {
          "city": "Novi Sad",
          "country": "Serbia",
          "facility": "Clinical Center of Vojvodina"
        },
        {
          "city": "Košice",
          "country": "Slovakia",
          "facility": "Artromac n.o."
        },
        {
          "city": "Piešťany",
          "country": "Slovakia",
          "facility": "Narodny ustav reumatickych chorob"
        },
        {
          "city": "Ansan-si",
          "country": "South Korea",
          "facility": "Korea University Ansan Hospital"
        },
        {
          "city": "Suwon",
          "country": "South Korea",
          "facility": "Ajou University Hospital"
        },
        {
          "city": "Daejeon",
          "country": "South Korea",
          "facility": "Chungnam National University Hospital"
        },
        {
          "city": "Gwangju",
          "country": "South Korea",
          "facility": "Chonnam National University Hospital"
        },
        {
          "city": "Seoul",
          "country": "South Korea",
          "facility": "Severance Hospital, Yonsei University Health System"
        },
        {
          "city": "Seoul",
          "country": "South Korea",
          "facility": "Hanyang University Seoul Hospital"
        },
        {
          "city": "Seoul",
          "country": "South Korea",
          "facility": "The Catholic University of Korea, Seoul St. Mary's Hospital"
        },
        {
          "city": "Badalona",
          "country": "Spain",
          "facility": "Hospital Universitari Germans Trias i Pujol"
        },
        {
          "city": "Valladolid",
          "country": "Spain",
          "facility": "Hospital Universitario Rio Hortega"
        },
        {
          "city": "Castellon",
          "country": "Spain",
          "facility": "Hospital General de Castellon"
        },
        {
          "city": "Alcorcón",
          "country": "Spain",
          "facility": "Hospital Universitario Fundacion Alcorcon"
        },
        {
          "city": "Majadahonda",
          "country": "Spain",
          "facility": "Hospital Universitario Puerta de Hierro Majadahonda"
        },
        {
          "city": "A Coruña",
          "country": "Spain",
          "facility": "Complejo Hospitalario Universitario A Coruña"
        },
        {
          "city": "Barcelona",
          "country": "Spain",
          "facility": "Hospital Universitari Vall d'Hebron - VHIR"
        },
        {
          "city": "Barcelona",
          "country": "Spain",
          "facility": "Hospital del Mar"
        },
        {
          "city": "Barcelona",
          "country": "Spain",
          "facility": "Hospital de la Santa Creu i Sant Pau"
        },
        {
          "city": "Córdoba",
          "country": "Spain",
          "facility": "Hospital Universitario Reina Sofia"
        },
        {
          "city": "Seville",
          "country": "Spain",
          "facility": "Hospital Universitario Virgen del Rocio"
        },
        {
          "city": "Stockholm",
          "country": "Sweden",
          "facility": "Karolinska Universitetssjukhuset - Solna"
        },
        {
          "city": "Zurich-Flughafen",
          "country": "Switzerland",
          "facility": "Universitaetsspital Zuerich"
        },
        {
          "city": "Lausanne",
          "country": "Switzerland",
          "facility": "Centre Hospitalier Universitaire Vaudois (CHUV)"
        },
        {
          "city": "Sankt Gallen",
          "country": "Switzerland",
          "facility": "Kantonsspital St. Gallen"
        },
        {
          "city": "Changhua",
          "country": "Taiwan",
          "facility": "Changhua Christian Medical Foundation Changhua Christian Hospital"
        },
        {
          "city": "Kaohsiung City",
          "country": "Taiwan",
          "facility": "Kaohsiung Chang Gung Memorial Hospital"
        },
        {
          "city": "Taichung",
          "country": "Taiwan",
          "facility": "Chung Shan Medical University Hospital"
        },
        {
          "city": "Taichung",
          "country": "Taiwan",
          "facility": "Taichung Veterans General Hospital"
        },
        {
          "city": "Taipei",
          "country": "Taiwan",
          "facility": "Taipei Veterans General Hospital"
        },
        {
          "city": "Cherkasy",
          "country": "Ukraine",
          "facility": "CNE Cherkasy Regional Hospital of Cherkasy Regional Council"
        },
        {
          "city": "Ivano-Frankivsk",
          "country": "Ukraine",
          "facility": "CNCE Regional Clinical Hospital of Ivano-Frankivsk Regional Council, Dept of Rheumatology"
        },
        {
          "city": "Kyiv",
          "country": "Ukraine",
          "facility": "Medical Center Artes Medicum LLC"
        },
        {
          "city": "Kyiv",
          "country": "Ukraine",
          "facility": "Med Center 'Ok!Clinic+' LLC \"International Institute of Clinical Research\""
        },
        {
          "city": "Lutsk",
          "country": "Ukraine",
          "facility": "Communal Enterprise Volyn Regional Clinical Hospital of Volyn Regional Council"
        },
        {
          "city": "Lviv",
          "country": "Ukraine",
          "facility": "Lviv Regional Clinical Hospital"
        },
        {
          "city": "Poltava",
          "country": "Ukraine",
          "facility": "Communal Enterprise M.V.Sklifosovskyi Poltava Regional Clinical Hospital of Poltava Regional Council"
        },
        {
          "city": "Ternopil",
          "country": "Ukraine",
          "facility": "CNE Ternopil Reg Clinical Hospital TRC, Dept of Rheumatology, SHEI I.Ya.HorbachevskyiTernopil SMU"
        },
        {
          "city": "Uzhhorod",
          "country": "Ukraine",
          "facility": "ZAKARPATTIA ENDOCLINIC LLC, Medical Center Endoclinic"
        },
        {
          "city": "Vinnytsia",
          "country": "Ukraine",
          "facility": "Private Small Enterprise Medical Center Pulse"
        },
        {
          "city": "Vinnytsia",
          "country": "Ukraine",
          "facility": "СNE M.I. Pyrogov RCH of Vinnytsia RC HSC Reum Osteo Bio Th"
        },
        {
          "city": "London",
          "country": "United Kingdom",
          "facility": "Whipps Cross University Hospital"
        },
        {
          "city": "Manchester",
          "country": "United Kingdom",
          "facility": "Manchester Royal Infirmary"
        },
        {
          "city": "Birmingham",
          "country": "United Kingdom",
          "facility": "Queen Elizabeth Hospital"
        },
        {
          "city": "Leeds",
          "country": "United Kingdom",
          "facility": "Chapel Allerton Hospital"
        }
      ],
      "outcomes": {
        "other": [],
        "primary": [
          "Parts A: Percentage of Participants who Achieve a Cutaneous Lupus Activity of Physician's Global Assessment-Revised (CLA-IGA-R) Erythema Score of 0 or 1",
          "Part B: Percentage of Participants who Achieve Cutaneous Lupus Erythematosus Disease Area and Severity Index Activity Score (CLASI-70) Response, Defined as ≥ 70% Decrease in CLASI-A Score From Baseline"
        ],
        "secondary": [
          "Part A: Percentage of Participants With a CLASI-70 Response at Week 52 Among CLASI-70 Responders at Week 16 and Week 24, Respectively, who Were Randomly Assigned to Receive Litifilimab During the DBPC Treatment Period (TP)",
          "Part A: Percentage of Participants With CLA-IGA-R Erythema Score of 0 or 1 at Week 52 Among CLA-IGA-R Erythema Responders at Week 16 and Week 24, Respectively, who Were Randomly Assigned to Receive Litifilimab During the DBPC TP",
          "Part A: Percentage of Participants With CLA-IGA-R OMC Score of 0 or 1 and at Least 1 Level of Improvement From Baseline at Week 52 Among CLA-IGA-R OMC Responders at Weeks 16 &24, Respectively, who Were Assigned to Receive Litifilimab in DBPC TP",
          "Part A: Percentage of Participants With CLA-IGA-R OMC Score of 0 at Week 52 Among CLA-IGA-R OMC Responders With CLA-IGA-R OMC Score of 0 at Week 16 and Week 24, Respectively, who Were Randomly Assigned to Litifilimab During DBPC TP",
          "Part A: Percentage of Participants With CLA-IGA-R Follicular Activity Score of 0 at Week 52 Among CLA-IGA-R Follicular Activity Responders at Week 16 and Week 24, Respectively, who Were Randomly Assigned to Receive Litifilimab in DBPC TP",
          "Part A: Percentage of Participants With a CLASI-70 Response at Week 52 Among CLASI-70 Nonresponders at Week 16 and Week 24, Respectively, who Were Randomly Assigned to Receive Placebo During the DBPC TP",
          "Part A: Percentage of Participants With a CLA-IGA-R Erythema Score of 0 or 1 at Week 52 Among CLA-IGA-R Erythema Nonresponders at Week 16 and Week 24, Respectively, who Were Randomly Assigned to Receive Placebo During the DBPC TP",
          "Part A: Percentage of Participants With CLA-IGA-R OMC Score of 0 or 1 and at Least 1 Level of Improvement From Baseline at Week 52 Among CLA-IGA-R OMC Nonresponders at Weeks 16 and 24, Respectively, who Were Assigned to Receive Placebo in DBPC TP",
          "Part A: Percentage of Participants With a CLA-IGA-R OMC Score of 0 at Week 52 Among CLA-IGA-R OMC Nonresponders at Week 16 and Week 24, Respectively, who Were Randomly Assigned to Receive Placebo During the DBPC TP",
          "Part A: Percentage of Participants who Have CLA-IGA-R Follicular Activity Score of 0 at Week 52 Among CLA-IGA-R Follicular Activity Nonresponders at Weeks 16 and 24, Respectively, who Were Randomly Assigned to Receive Placebo in DBPC TP",
          "Part A: Annualized Mild and Moderate SFI Rate and Annualized Severe SFI Rate Through Week 16",
          "Part A: Absolute Change in Cutaneous Lupus Erythematosus Disease Area and Severity Index Damage (CLASI-D) Score at Week 52",
          "Part A: Percent Change in CLASI-D Score",
          "Part B: Percentage of Participants who Achieve a CLASI A score of 0 to 3",
          "Part B: Percentage of Participants who Achieve a CLA-IGA-R OMC Score of 0 or 1 and at Least 2-Point Improvement From Baseline at Week 24, for Participants who had CLA-IGA-R OMC Score ≥ 2 at Baseline",
          "Part B: Percentage of Participants who Achieve a CLA-IGA-R Erythema Score of 0 or 1, at Week 16 and Week 24, Respectively, for Participants in Full Analysis Set (FAS), who had CLA-IGA-R Erythema Score ≥3 and Other OMC Score ≥3 at Baseline",
          "Part B: Percentage of Participants who Achieve a CLA-IGA-R OMC Score of 0 or 1, at Week 16 and Week 24, Respectively, for Participants in FAS, who had CLA-IGA-R Erythema Score ≥3 and OMC Score ≥3 at Baseline",
          "Part B: Percentage of Participants who Achieve CLA IGA R Erythema Score of 0 or 1",
          "Part B: Percentage of Participants who Achieve at Least 1 Level of Improvement From Baseline in the CLA-IGA-R Erythema Score",
          "Part B: Percentage of Participants who Achieve a CLASI-A Score of 0 to 5",
          "Part B: Percentage of Participants who Achieve a CLASI-50a Response, Defined as a ≥ 50% Decrease in Baseline CLASI-A Score in Addition to Achieving Mild Disease Severity With a CLASI-A Score <10 at Week 16 and Week 24, Respectively",
          "Part B: Percentage of Participants With a CLASI 70 Response at Week 52 Among CLASI-70 Responders at Week 24, who Were Randomly Assigned to Receive Litifilimab During the DBPC TP",
          "Part B: Percentage of Participants With a CLASI 50 Response at Week 52 Among CLASI-50 Responders at Week 24, who Were Randomly Assigned to Receive Litifilimab During the DBPC TP",
          "Part B: Percentage of Participants With a CLASI A 0 to 3 Response at Week 52 Among CLASI-A 0 to 3 Responders at Week 24, who Were Randomly Assigned to Receive Litifilimab During the DBPC TP",
          "Part B: Percentage of Participants With a CLA IGA R Erythema Score of 0 or 1 at Week 52 Among CLA-IGA-R Erythema Responders at Week 24, who Were Randomly Assigned to Receive Litifilimab During the DBPC TP",
          "Part B: Percentage of Participants With a CLA IGA R OMC score of 0 at Week 52 Among CLA IGA R OMC Responders With a CLA-IGA-R OMC Score of 0 at Week 24, who Were Randomly Assigned to Receive Litifilimab During the DBPC TP",
          "Part B: Percentage of Participants With a CLA IGA-R Follicular Activity Score of 0 at Week 52 Among CLA-IGA-R Follicular Activity Responders at Week 24, who Were Randomly Assigned to Receive Litifilimab During the DBPC TP",
          "Part B: Percentage of Participants With a CLASI 70 Response at Week 52 Among CLASI-70 Nonresponders at Week 24, who Were Randomly Assigned to Receive Litifilimab During the DBPC TP",
          "Part B: Percentage of Participants With a CLASI 50 Response at Week 52 Among CLASI-50 Nonresponders at Week 24, who Were Randomly Assigned to Receive Litifilimab During the DBPC TP",
          "Part B: Percentage of Participants With a CLASI A 0 to 3 Response at Week 52 Among CLASI-A 0 to 3 Nonresponders at Week 24, who Were Randomly Assigned to Receive Litifilimab During the DBPC TP",
          "Part B: Percentage of Participants With a CLA IGA R Erythema Score of 0 or 1 at Week 52 Among CLA-IGA-R Erythema Nonresponders at Week 24, who Were Randomly Assigned to Receive Litifilimab During the DBPC TP",
          "Part B: Percentage of Participants With a CLA IGA R OMC score of 0 at Week 52 Among CLA IGA R OMC Nonresponders With a CLA-IGA-R OMC Score of 0 at Week 24, who Were Randomly Assigned to Receive Litifilimab During the DBPC TP",
          "Part B: Percentage of Participants With a CLA IGA-R Follicular Activity Score of 0 at Week 52 Among CLA-IGA-R Follicular Activity Nonresponders at Week 24, who Were Randomly Assigned to Receive Litifilimab During the DBPC TP",
          "Part B: Absolute Change in CLASI-D Score",
          "Part B: Percent Change in CLASI-D Score",
          "Part B: Change From Baseline in Cutaneous Lupus Erythematosus-Quality of Life (CLE-QoL) Score",
          "Part B: Change From Baseline in Dermatology Life Quality Index (DLQI) Score",
          "Part B: Change From Baseline in Numerical Rating Scale (NRS) for Pain in Skin Rash",
          "Part B: Change From Baseline in NRS for Itch in Skin Rash",
          "Parts A and B: Percentage of Participants who Achieve a CLA-IGA-R Erythema Score of 0 or 1",
          "Parts A and B: Percentage of Participants who Achieve a CLA-IGA-R Other Morphologic Characteristics (OMC) Score of 0 or 1 and at Least 1 Level of Improvement From Baseline",
          "Parts A and B: Percentage of Participants who Achieve a CLA-IGA-R OMC Score of 0",
          "Parts A and B: Percentage of Participants With at Least 1 Level of Improvement From Baseline in CLA-IGA-R OMC Score",
          "Parts A and B: Percentage of Participants who Have a CLA-IGA-R Follicular Activity Score of 0",
          "Parts A and B: Percentage of Participants who Achieve a CLASI-70 Response, Defined as a ≥ 70% Decrease in CLASI-A Score From Baseline",
          "Parts A and B: Percentage of Participants who Achieve a CLASI-50 Response, Defined as a ≥ 50% Decrease in CLASI-A Score From Baseline",
          "Parts A and B: Percentage of Participants who Achieve a CLASI-A Score of 0 or 1",
          "Parts A and B: Percentage of Participants who Achieve a CLASI-A Score of 0 to 3",
          "Parts A and B: Percentage of Participants who Achieve a CLASI 70 Response",
          "Parts A and B: Percentage of Participants who Achieve a CLASI 50 Response",
          "Parts A and B: Percentage of Participants who Achieve a 7-Point Reduction From Baseline in CLASI-A Score",
          "Parts A and B: Annualized Mild and Moderate Safety of Estrogens in Lupus Erythematosus National Assessment-SLE Disease Activity Index Flare Index Rate and Annualized Severe SFI Rate Through Week 24",
          "Parts A and B: Annualized Mild and Moderate SFI Rate and Annualized Severe SFI Rate Through Week 52",
          "Parts A and B: Number of Participants Experiencing Treatment Emergent Adverse Events (TEAEs) and Serious Adverse Events (SAEs)",
          "Parts A and B: Number of Participants With Anti-Litifilimab Antibodies in Serum During the Study"
        ]
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      "eligibility": {
        "sex": "ALL",
        "criteria": "Key Inclusion Criteria:\n\n1. Histologically confirmed (in the past or during the Screening period) diagnosis of CLE with or without systemic manifestations.\n2. Must have active cutaneous manifestations that meet study criteria.\n3. Must have a CLASI-A score ≥10.\n4. Must have an active CLE lesion despite an adequate trial of antimalarial treatment.\n\nKey Exclusion Criteria:\n\n1. Any active skin conditions other than CLE that may interfere with the study assessments of CLE.\n2. Diagnosis of mixed connective tissue disease \\[(within 1 year of signing the informed consent form (ICF)\\] or any history of overlap syndromes of SLE including concomitant presence with rheumatoid arthritis, dermatomyositis and/or polymyositis, systemic sclerosis, psoriatic arthritis, or any other autoimmune disease that may confound the evaluation of the disease activity or the effect of the investigational product. Exceptions for overlap syndrome of SLE include participants with overlap syndrome of SLE with myositis and secondary Sjögren's syndrome at screening is permitted provided the participant also meets the criteria for classification as SLE. A past history of mixed connective tissue disease that over time has developed into a diagnosis of SLE is permitted, provided diagnosis of SLE has been present for at least 1 year.\n3. Active severe lupus nephritis.\n4. Active neuropsychiatric SLE.\n5. Use of intralesional corticosteroids within 1 week prior to Screening and during the study.\n6. Use of immunosuppressive or disease-modifying treatments for SLE or CLE \\[via an oral, intravenous (IV), or SC route\\] that were initiated less than 12 weeks prior to screening, have not been at a stable and allowable dose.\n\nNOTE: Other protocol-defined Inclusion/Exclusion criteria may apply",
        "minimumAge": "18 Years",
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      "enrollment": {
        "type": "ESTIMATED",
        "count": 450
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      "startDate": "2022-09-13",
      "completionDate": "2027-12-14",
      "lastUpdated": "2026-10-23T00:00:00.000Z",
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