{ "data": { "asOf": "2026-10-30T22:26:13.531Z", "dedupMethod": "exact cross-registry identifier matching; probabilistic = review only", "byRegistry": { "clinicaltrials_gov": 1 }, "canonicalTrial": { "canonicalId": "NCT04715750", "title": "Evaluation of Imaging Characteristics of [18F]PI-2620 PET in AD and PSP Patients Using High and Low Specific Activity", "scientificTitle": "An Open Label, Single Center Study to Evaluate the Safety and Imaging Characteristics of [18F]PI-2620 as PET Radioligand for Imaging Tau Deposition in the Brains of Patients With Mild to Moderate Alzheimer's Disease (AD) and Patients With Progressive Supranuclear Palsy (PSP) After i.v. Application of [18F]PI-2620 With High and Low Specific Activity", "status": "completed", "studyType": "interventional", "phase": [ "PHASE1" ], "conditions": [ "Alzheimer Disease", "Progressive Supranuclear Palsy" ], "interventions": [ { "name": "[18F]-PI2620", "type": "DRUG", "description": "\\[18F\\]PI-2620 is a radioactive diagnostic agent being developed for the indication of PET imaging of the brain to detect tau pathology in adult patients who are being evaluated for neurodegenerative decline. All patients will receive two administrations of \\[18F\\]PI-2620 at a radioactive dose of 185 MBq, one with high specific activity (≤ 5 µg tracer mass dose), another one with low specific activity (40-50 µg tracer mass dose)." } ], "sponsor": { "name": "Life Molecular Imaging GmbH", "type": "INDUSTRY" }, "locations": [ { "city": "Leipzig", "country": "Germany", "facility": "Department of Nuclear Medicine, University Hospital Leipzig" } ], "outcomes": { "other": [], "primary": [ "Comparability of visual assessment of PI-2620 tau PET images obtained after injection of high specific activity and low specific activity in AD and PSP patients." ], "secondary": [ "Comparability of quantitative assessment of PI-2620 tau PET images obtained after injection of high specific activity and low specific activity in AD and PSP patients.", "Number of adverse events" ] }, "eligibility": { "sex": "ALL", "criteria": "Inclusion Criteria:\n\n* Males and females aged 50-80 years\n* Able to understand, sign and date written informed consent, which is confirmed by the judgment of the referring physician\n* Written informed consent must be obtained before any assessment is performed\n* Prior evaluable MRI\n* Female patients must be documented by medical records or physician's note to be either surgically sterile (by means of hysterectomy, bilateral salpingectomy or bilateral oophorectomy) or post-menopausal for at least 1 year (no menses for 12 months without an alternative medical cause). If they are of child-bearing potential, must commit to use of a highly effective contraceptive measure for the duration of the study\n* Male patients and their partners of childbearing potential must commit to the use of a highly effective method of contraception for a minimum of one week following each PET scan\n* Male patients must commit to not donate sperm for a minimum of one week after each PET scan.\n\nInclusion Criteria for mild-moderate AD patients\n\n* Patients with mild or moderate AD in accordance with NIA-AA guidelines 2011\n* Have a CDR score of ≥ 0.5 at screening\n* Have an MMSE score of ≤ 24 at screening\n* Prior evaluable amyloid PET imaging confirming presence of beta-amyloid brain pathology\n* Medications taken for symptomatic treatment of AD must be maintained on a stable dosage regimen for at least 30 days before the \\[18F\\]PI-2620 PET imaging visits\n\nInclusion Criteria for patients with probable PSP\n\n* Patients with a clinical diagnosis of probable PSP based on the Movement Disorder Society criteria (Höglinger et al., 2017).\n* Have a PSP rating score between 20 - 60\n* Medications taken for symptomatic treatment of PSP must be maintained on a stable dosage regimen for at least 30 days before the \\[18F\\]PI-2620 PET imaging visits\n\nExclusion Criteria (for all patients)\n\n* Laboratory tests with clinically significant abnormalities and/or clinically significant unstable medical illness equivalent to CTC v5.0 (common toxicity criteria) toxicities greater than grade 2\n* Evidence of clinically significant disease that is expected to interfere with cognitive assessments or the ability to complete the study procedures\n* Patient has received an investigational drug including treatments targeting amyloid-beta plaques or tau within 3 months of screening\n* Pregnant (or intention of getting pregnant), lactating or breastfeeding\n* MRI exclusion criteria include: Findings of cerebrovascular disease (more than two lacunar infarcts, any territorial infarct \\>1 cm3, or deep white matter abnormality corresponding to an overall Fazekas scale of 3 with at least one confluent hyperintense lesion on the Fluid-Attenuated Inversion Recovery (FLAIR) sequence that is \\>=20 mm in any dimension), infectious disease, space-occupying lesions, normal pressure hydrocephalus or any other abnormalities associated with Central Nervous System (CNS) disease\n* Implants such as implanted cardiac pacemakers or defibrillators, insulin pumps, cochlear implants, metallic ocular foreign body, implanted neural stimulators, CNS aneurysm clips and other medical implants that have not been certified for MRI, or history of claustrophobia in MRI\n* Unwilling and/or unable to cooperate with study procedures", "maximumAge": "80 Years", "minimumAge": "50 Years", "healthyVolunteers": false }, "enrollment": { "type": "ACTUAL", "count": 10 }, "startDate": "2020-11-12", "completionDate": "2022-10-26", "lastUpdated": "2026-10-26T00:00:00.000Z", "firstPosted": "2021-01-20T00:00:00.000Z", "resultsAvailable": false, "sourceRegistries": [ "clinicaltrials_gov" ], "sourceUrls": [ "https://clinicaltrials.gov/study/NCT04715750" ] }, "identifiers": [ { "idType": "nct", "idValue": "NCT04715750", "declaredBy": "clinicaltrials_gov" } ], "sourceRecords": [ { "registry": "clinicaltrials_gov", "registryName": "ClinicalTrials.gov", "license": "public-domain", "sourceId": "NCT04715750", "sourceUrl": "https://clinicaltrials.gov/study/NCT04715750", "sourceStatus": "COMPLETED", "retrievedAt": "2026-10-28T04:32:50.762Z", "payloadSha256": "4466130269107ddb6186d7099a7d04c4dd3d7840853ab632af0927f0dd17e094", "piiRedacted": true } ], "citation": { "canonicalId": "NCT04715750", "sources": [ { "registry": "clinicaltrials_gov", "registryName": "ClinicalTrials.gov", "license": "public-domain", "sourceId": "NCT04715750", "verifyAt": "https://clinicaltrials.gov/study/NCT04715750", "retrievedAt": "2026-10-28T04:32:50.762Z", "payloadSha256": "4466130269107ddb6186d7099a7d04c4dd3d7840853ab632af0927f0dd17e094", "text": "ClinicalTrials.gov, record NCT04715750 (https://clinicaltrials.gov/study/NCT04715750), retrieved 2026-10-28, licence: public-domain." } ], "crossRegistry": false, "dedupMethod": "exact cross-registry identifier matching; probabilistic = review only", "text": "Trial NCT04715750, registered in ClinicalTrials.gov, retrieved 2026-10-28. Verify at the source URLs listed; each retrieval is checksummed.", "note": "Only one registry is known to hold this trial. Absence from the others is not evidence it was not registered there." }, "provenanceNote": "Personal contact fields (names, emails, phone numbers, addresses) are stripped from every stored payload. No participant-level data is collected or served." }, "_meta": { "api": "The Last Economy Wire: World Trials API", "version": "1.0", "schemaVersion": "1", "correlationId": "req_1cdI7tcike8i", "generatedAt": "2026-10-30T22:26:13.531Z", "documentation": "https://negativeresistance.com/embed", "license": "Free for any use. Attribution appreciated.", "degraded": false, "provenance": { "sources": [ "clinicaltrials_gov" ], "attribution": { "clinicaltrials_gov": "ClinicalTrials.gov: licence: public-domain, https://clinicaltrials.gov/data-api/api-docs" }, "dedupMethod": "exact cross-registry identifier matching; probabilistic = review only", "limitations": [], "provenanceEndpoint": "/api/v1/sources" }, "freshness": { "newestEvidenceAt": null, "lastSyncedAt": { "clinicaltrials_gov": "2026-10-28T04:33:30.663Z" }, "degradedSources": [], "worldwide": false, "maxAgeHours": 65.9, "fromCache": false }, "links": { "discovery": "https://negativeresistance.com/api/v1", "openapi": "https://negativeresistance.com/api/v1/openapi.json", "mcp": "https://negativeresistance.com/api/v1/mcp", "agentCard": "https://negativeresistance.com/.well-known/agent.json", "aiPlugin": "https://negativeresistance.com/.well-known/ai-plugin.json", "sdk": "https://negativeresistance.com/api/v1/sdk", "status": "https://negativeresistance.com/api/v1/status", "provenance": "https://negativeresistance.com/api/v1/sources", "contract": "https://negativeresistance.com/api/v1/contract", "curriculum": "https://negativeresistance.com/api/v1/curriculum", "graph": "https://negativeresistance.com/api/v1/graph", "openQuestions": "https://negativeresistance.com/api/v1/open-questions", "scoreboard": "https://negativeresistance.com/api/v1/scoreboard", "findings": "https://negativeresistance.com/api/v1/findings", "claims": "https://negativeresistance.com/api/v1/claims", "threads": "https://negativeresistance.com/api/v1/threads", "assignment": "https://negativeresistance.com/api/v1/assignment", "changes": "https://negativeresistance.com/api/v1/changes", "hello": "https://negativeresistance.com/api/v1/hello", "errors": "https://negativeresistance.com/api/v1/errors", "webhooks": "https://negativeresistance.com/api/v1/webhooks", "a2a": "https://negativeresistance.com/api/v1/a2a", "deadEnds": "https://negativeresistance.com/api/v1/dead-ends", "decompositions": "https://negativeresistance.com/api/v1/decompositions", "rungs": "https://negativeresistance.com/api/v1/rungs", "methods": "https://negativeresistance.com/api/v1/methods", "reality": "https://negativeresistance.com/api/v1/reality", "council": "https://negativeresistance.com/api/v1/council", "calibration": "https://negativeresistance.com/api/v1/calibration", "freshness": "https://negativeresistance.com/api/v1/freshness", "mission": "https://negativeresistance.com/api/v1/mission", "twin": "https://negativeresistance.com/api/v1/twin", "twinExperiment": "https://negativeresistance.com/api/v1/twin/experiment", "betaCell": "https://negativeresistance.com/api/v1/twin/beta-cell", "patientModel": "https://negativeresistance.com/api/v1/twin/patient-model", "agentCardCanonical": "https://negativeresistance.com/.well-known/agent-card.json", "collaborate": "https://negativeresistance.com/collaborate", "manifesto": "https://negativeresistance.com/about", "documentation": "https://negativeresistance.com/embed", "connect": "https://negativeresistance.com/connect", "llmsTxt": "https://negativeresistance.com/llms.txt", "llmsFullTxt": "https://negativeresistance.com/llms-full.txt" }, "disclaimer": "Research data from public registries and literature; not medical advice." } }