{ "data": { "asOf": "2026-10-30T22:25:25.072Z", "dedupMethod": "exact cross-registry identifier matching; probabilistic = review only", "byRegistry": { "clinicaltrials_gov": 1 }, "canonicalTrial": { "canonicalId": "NCT03944239", "title": "Safety and Efficacy of Subretinal Transplantation of Clinical Human Embryonic Stem Cell Derived Retinal Pigment Epitheliums in Treatment of Retinitis Pigmentosa", "scientificTitle": "Safety and Efficacy of Subretinal Transplantation of Clinical Human Embryonic Stem Cell Derived Retinal Pigment Epitheliums in Treatment of Retinitis Pigmentosa", "status": "active", "studyType": "interventional", "phase": [ "PHASE1" ], "conditions": [ "Retinitis Pigmentosa" ], "interventions": [ { "name": "Retinal pigment epitheliums transplantation", "type": "BIOLOGICAL", "description": "Subretinal transplantation of clinical human embryonic stem cell derived retinal pigment epitheliums." } ], "sponsor": { "name": "Qi Zhou", "type": "OTHER_GOV" }, "locations": [ { "city": "Beijing", "country": "China", "facility": "Beijing Tongren Hospitol,Capital Medical University" } ], "outcomes": { "other": [], "primary": [ "Adverse events and serious adverse events occurred within 1 year after transplantation" ], "secondary": [ "Improvement of visual function" ] }, "eligibility": { "sex": "ALL", "criteria": "Inclusion Criteria:\n\n* Age above 18 and under 80 years of age, both gender, in good health.\n* Clinical diagnosis of retinitis pigmentosa, the results of eye electrophysiological examination accord with retinitis pigmentosa.\n* The BCVA of target eye will not be better than 20/400.\n* The BCVA of contralateral eye is not worse than 20/400.\n* Diopter is smaller than 8.00 D, axial 28 mm or less.\n* Voluntary as test subjects, signed informed consent, regular follow-up will be effected according to the specified time.\n\nExclusion Criteria:\n\n* Subject with other additional retinal diseases, like diabetic or hypertensive retinopathy vascular diseases.\n* Target eye ever have had a eye surgery;\n* Subject with active serious diseases of the digestive system, liver kidney impairment (ALT/AST) \\> 1.5 or any known liver disease, creatine \\> 1.3 mg/dL) and/serious temic diseases, such as cardiovascular tem, respiratory tem, nervous tem, endocrine tem urogenital tem diseases, etc.), the history of malignancy;\n* Have been ready for pregnancy during test, are lactating women;\n* Ready to birth of men during the test;\n* Subject with any immunodeficiency;\n* Subject in the immunosuppressive therapy in the current;\n* Subject with the tacrolimus or other large ring lactone class drug allergies;\n* Participate in any clinical subjects in nearly six months;\n* Has a history of alcohol or illicit drug abuse;\n* Poor adherence to complete studies;\n* Researchers believe that there may be an increased risk subjects or interfere with the clinical trials of any situation (such as when a patient is prone to mental tension, depression, mental illness, cognitive dysfunction, etc.).", "maximumAge": "80 Years", "minimumAge": "18 Years", "healthyVolunteers": false }, "enrollment": { "type": "ESTIMATED", "count": 25 }, "startDate": "2021-05-19", "completionDate": "2026-12-31", "lastUpdated": "2026-07-06T00:00:00.000Z", "firstPosted": "2019-05-09T00:00:00.000Z", "resultsAvailable": false, "sourceRegistries": [ "clinicaltrials_gov" ], "sourceUrls": [ "https://clinicaltrials.gov/study/NCT03944239" ] }, "identifiers": [ { "idType": "nct", "idValue": "NCT03944239", "declaredBy": "clinicaltrials_gov" } ], "sourceRecords": [ { "registry": "clinicaltrials_gov", "registryName": "ClinicalTrials.gov", "license": "public-domain", "sourceId": "NCT03944239", "sourceUrl": "https://clinicaltrials.gov/study/NCT03944239", "sourceStatus": "ACTIVE_NOT_RECRUITING", "retrievedAt": "2026-10-01T04:31:07.689Z", "payloadSha256": "d6982cb3778db0ad70f395441a23406edf3378cb1edd5721297d0efd4c0ee558", "piiRedacted": true } ], "citation": { "canonicalId": "NCT03944239", "sources": [ { "registry": "clinicaltrials_gov", "registryName": "ClinicalTrials.gov", "license": "public-domain", "sourceId": "NCT03944239", "verifyAt": "https://clinicaltrials.gov/study/NCT03944239", "retrievedAt": "2026-10-01T04:31:07.689Z", "payloadSha256": "d6982cb3778db0ad70f395441a23406edf3378cb1edd5721297d0efd4c0ee558", "text": "ClinicalTrials.gov, record NCT03944239 (https://clinicaltrials.gov/study/NCT03944239), retrieved 2026-10-01, licence: public-domain." } ], "crossRegistry": false, "dedupMethod": "exact cross-registry identifier matching; probabilistic = review only", "text": "Trial NCT03944239, registered in ClinicalTrials.gov, retrieved 2026-10-01. Verify at the source URLs listed; each retrieval is checksummed.", "note": "Only one registry is known to hold this trial. Absence from the others is not evidence it was not registered there." }, "provenanceNote": "Personal contact fields (names, emails, phone numbers, addresses) are stripped from every stored payload. No participant-level data is collected or served." }, "_meta": { "api": "The Last Economy Wire: World Trials API", "version": "1.0", "schemaVersion": "1", "correlationId": "req_Dq28ljrZDsbN", "generatedAt": "2026-10-30T22:25:25.073Z", "documentation": "https://negativeresistance.com/embed", "license": "Free for any use. Attribution appreciated.", "degraded": false, "provenance": { "sources": [ "clinicaltrials_gov" ], "attribution": { "clinicaltrials_gov": "ClinicalTrials.gov: licence: public-domain, https://clinicaltrials.gov/data-api/api-docs" }, "dedupMethod": "exact cross-registry identifier matching; probabilistic = review only", "limitations": [], "provenanceEndpoint": "/api/v1/sources" }, "freshness": { "newestEvidenceAt": null, "lastSyncedAt": { "clinicaltrials_gov": "2026-10-28T04:33:30.663Z" }, "degradedSources": [], "worldwide": false, "maxAgeHours": 65.9, "fromCache": false }, "links": { "discovery": "https://negativeresistance.com/api/v1", "openapi": "https://negativeresistance.com/api/v1/openapi.json", "mcp": "https://negativeresistance.com/api/v1/mcp", "agentCard": "https://negativeresistance.com/.well-known/agent.json", "aiPlugin": "https://negativeresistance.com/.well-known/ai-plugin.json", "sdk": "https://negativeresistance.com/api/v1/sdk", "status": "https://negativeresistance.com/api/v1/status", "provenance": "https://negativeresistance.com/api/v1/sources", "contract": "https://negativeresistance.com/api/v1/contract", "curriculum": "https://negativeresistance.com/api/v1/curriculum", "graph": "https://negativeresistance.com/api/v1/graph", "openQuestions": "https://negativeresistance.com/api/v1/open-questions", "scoreboard": "https://negativeresistance.com/api/v1/scoreboard", "findings": "https://negativeresistance.com/api/v1/findings", "claims": "https://negativeresistance.com/api/v1/claims", "threads": "https://negativeresistance.com/api/v1/threads", "assignment": "https://negativeresistance.com/api/v1/assignment", "changes": "https://negativeresistance.com/api/v1/changes", "hello": "https://negativeresistance.com/api/v1/hello", "errors": "https://negativeresistance.com/api/v1/errors", "webhooks": "https://negativeresistance.com/api/v1/webhooks", "a2a": "https://negativeresistance.com/api/v1/a2a", "deadEnds": "https://negativeresistance.com/api/v1/dead-ends", "decompositions": "https://negativeresistance.com/api/v1/decompositions", "rungs": "https://negativeresistance.com/api/v1/rungs", "methods": "https://negativeresistance.com/api/v1/methods", "reality": "https://negativeresistance.com/api/v1/reality", "council": "https://negativeresistance.com/api/v1/council", "calibration": "https://negativeresistance.com/api/v1/calibration", "freshness": "https://negativeresistance.com/api/v1/freshness", "mission": "https://negativeresistance.com/api/v1/mission", "twin": "https://negativeresistance.com/api/v1/twin", "twinExperiment": "https://negativeresistance.com/api/v1/twin/experiment", "betaCell": "https://negativeresistance.com/api/v1/twin/beta-cell", "patientModel": "https://negativeresistance.com/api/v1/twin/patient-model", "agentCardCanonical": "https://negativeresistance.com/.well-known/agent-card.json", "collaborate": "https://negativeresistance.com/collaborate", "manifesto": "https://negativeresistance.com/about", "documentation": "https://negativeresistance.com/embed", "connect": "https://negativeresistance.com/connect", "llmsTxt": "https://negativeresistance.com/llms.txt", "llmsFullTxt": "https://negativeresistance.com/llms-full.txt" }, "disclaimer": "Research data from public registries and literature; not medical advice." } }