{
  "data": {
    "asOf": "2026-10-30T22:27:23.932Z",
    "dedupMethod": "exact cross-registry identifier matching; probabilistic = review only",
    "byRegistry": {
      "clinicaltrials_gov": 1
    },
    "canonicalTrial": {
      "canonicalId": "NCT03516279",
      "title": "Pembrolizumab and Dasatinib, Imatinib Mesylate, or Nilotinib in Treating Patients With Chronic Myeloid Leukemia and Persistently Detectable Minimal Residual Disease",
      "scientificTitle": "Phase II Study of Adding the Anti-PD-1 Pembrolizumab to Tyrosine Kinase Inhibitors in Patients With Chronic Myeloid Leukemia and Persistently Detectable Minimal Residual Disease",
      "status": "active",
      "studyType": "interventional",
      "phase": [
        "PHASE2"
      ],
      "conditions": [
        "Chronic Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive",
        "Minimal Residual Disease"
      ],
      "interventions": [
        {
          "name": "Dasatinib",
          "type": "DRUG",
          "description": "Given PO"
        },
        {
          "name": "Imatinib Mesylate",
          "type": "DRUG",
          "description": "Given PO"
        },
        {
          "name": "Laboratory Biomarker Analysis",
          "type": "OTHER",
          "description": "Correlative studies"
        },
        {
          "name": "Nilotinib",
          "type": "DRUG",
          "description": "Given PO"
        },
        {
          "name": "Pembrolizumab",
          "type": "BIOLOGICAL",
          "description": "Given IV"
        }
      ],
      "sponsor": {
        "name": "ECOG-ACRIN Cancer Research Group",
        "type": "NETWORK"
      },
      "locations": [
        {
          "city": "Fairbanks",
          "country": "United States",
          "facility": "Fairbanks Memorial Hospital"
        },
        {
          "city": "Goodyear",
          "country": "United States",
          "facility": "CTCA at Western Regional Medical Center"
        },
        {
          "city": "Phoenix",
          "country": "United States",
          "facility": "Cancer Center at Saint Joseph's"
        },
        {
          "city": "Fort Smith",
          "country": "United States",
          "facility": "Mercy Hospital Fort Smith"
        },
        {
          "city": "Hot Springs",
          "country": "United States",
          "facility": "CHI Saint Vincent Cancer Center Hot Springs"
        },
        {
          "city": "Little Rock",
          "country": "United States",
          "facility": "CARTI Cancer Center"
        },
        {
          "city": "Arroyo Grande",
          "country": "United States",
          "facility": "Mission Hope Medical Oncology - Arroyo Grande"
        },
        {
          "city": "Carmichael",
          "country": "United States",
          "facility": "Mercy Cancer Center - Carmichael"
        },
        {
          "city": "Carmichael",
          "country": "United States",
          "facility": "Mercy San Juan Medical Center"
        },
        {
          "city": "Elk Grove",
          "country": "United States",
          "facility": "Mercy Cancer Center - Elk Grove"
        },
        {
          "city": "Martinez",
          "country": "United States",
          "facility": "Contra Costa Regional Medical Center"
        },
        {
          "city": "Merced",
          "country": "United States",
          "facility": "Mercy Cancer Center"
        },
        {
          "city": "Rocklin",
          "country": "United States",
          "facility": "Mercy Cancer Center - Rocklin"
        },
        {
          "city": "Sacramento",
          "country": "United States",
          "facility": "Mercy Cancer Center - Sacramento"
        },
        {
          "city": "San Luis Obispo",
          "country": "United States",
          "facility": "Pacific Central Coast Health Center-San Luis Obispo"
        },
        {
          "city": "Santa Maria",
          "country": "United States",
          "facility": "Mission Hope Medical Oncology - Santa Maria"
        },
        {
          "city": "Walnut Creek",
          "country": "United States",
          "facility": "BASS Medical Group - Lennon"
        },
        {
          "city": "Woodland",
          "country": "United States",
          "facility": "Woodland Memorial Hospital"
        },
        {
          "city": "Aurora",
          "country": "United States",
          "facility": "Rocky Mountain Cancer Centers-Aurora"
        },
        {
          "city": "Boulder",
          "country": "United States",
          "facility": "Boulder Community Foothills Hospital"
        },
        {
          "city": "Boulder",
          "country": "United States",
          "facility": "Rocky Mountain Cancer Centers-Boulder"
        },
        {
          "city": "Centennial",
          "country": "United States",
          "facility": "Rocky Mountain Cancer Centers - Centennial"
        },
        {
          "city": "Colorado Springs",
          "country": "United States",
          "facility": "Penrose-Saint Francis Healthcare"
        },
        {
          "city": "Colorado Springs",
          "country": "United States",
          "facility": "Rocky Mountain Cancer Centers-Penrose"
        },
        {
          "city": "Colorado Springs",
          "country": "United States",
          "facility": "Saint Francis Cancer Center"
        },
        {
          "city": "Denver",
          "country": "United States",
          "facility": "The Women's Imaging Center"
        },
        {
          "city": "Denver",
          "country": "United States",
          "facility": "Porter Adventist Hospital"
        },
        {
          "city": "Denver",
          "country": "United States",
          "facility": "Colorado Blood Cancer Institute"
        },
        {
          "city": "Denver",
          "country": "United States",
          "facility": "Presbyterian - Saint Lukes Medical Center - Health One"
        },
        {
          "city": "Denver",
          "country": "United States",
          "facility": "Rocky Mountain Cancer Centers-Midtown"
        },
        {
          "city": "Denver",
          "country": "United States",
          "facility": "Rocky Mountain Cancer Centers-Rose"
        },
        {
          "city": "Denver",
          "country": "United States",
          "facility": "Rose Medical Center"
        },
        {
          "city": "Durango",
          "country": "United States",
          "facility": "Mercy Medical Center"
        },
        {
          "city": "Durango",
          "country": "United States",
          "facility": "Southwest Oncology PC"
        },
        {
          "city": "Englewood",
          "country": "United States",
          "facility": "Mountain Blue Cancer Care Center - Swedish"
        },
        {
          "city": "Englewood",
          "country": "United States",
          "facility": "Rocky Mountain Cancer Centers - Swedish"
        },
        {
          "city": "Englewood",
          "country": "United States",
          "facility": "Swedish Medical Center"
        },
        {
          "city": "Englewood",
          "country": "United States",
          "facility": "The Melanoma and Skin Cancer Institute"
        },
        {
          "city": "Golden",
          "country": "United States",
          "facility": "Mountain Blue Cancer Care Center"
        },
        {
          "city": "Lakewood",
          "country": "United States",
          "facility": "Rocky Mountain Cancer Centers-Lakewood"
        },
        {
          "city": "Lakewood",
          "country": "United States",
          "facility": "Saint Anthony Hospital"
        },
        {
          "city": "Littleton",
          "country": "United States",
          "facility": "Rocky Mountain Cancer Centers-Littleton"
        },
        {
          "city": "Littleton",
          "country": "United States",
          "facility": "Littleton Adventist Hospital"
        },
        {
          "city": "Lone Tree",
          "country": "United States",
          "facility": "Rocky Mountain Cancer Centers-Sky Ridge"
        },
        {
          "city": "Longmont",
          "country": "United States",
          "facility": "Longmont United Hospital"
        },
        {
          "city": "Longmont",
          "country": "United States",
          "facility": "Rocky Mountain Cancer Centers-Longmont"
        },
        {
          "city": "Parker",
          "country": "United States",
          "facility": "Parker Adventist Hospital"
        },
        {
          "city": "Parker",
          "country": "United States",
          "facility": "Rocky Mountain Cancer Centers-Parker"
        },
        {
          "city": "Pueblo",
          "country": "United States",
          "facility": "Saint Mary Corwin Medical Center"
        },
        {
          "city": "Pueblo",
          "country": "United States",
          "facility": "Rocky Mountain Cancer Centers - Pueblo"
        },
        {
          "city": "Thornton",
          "country": "United States",
          "facility": "Rocky Mountain Cancer Centers-Thornton"
        },
        {
          "city": "Derby",
          "country": "United States",
          "facility": "Smilow Cancer Hospital-Derby Care Center"
        },
        {
          "city": "Fairfield",
          "country": "United States",
          "facility": "Smilow Cancer Hospital Care Center-Fairfield"
        },
        {
          "city": "Glastonbury",
          "country": "United States",
          "facility": "Smilow Cancer Hospital Care Center at Glastonbury"
        },
        {
          "city": "Guilford",
          "country": "United States",
          "facility": "Smilow Cancer Hospital Care Center - Guilford"
        },
        {
          "city": "Hartford",
          "country": "United States",
          "facility": "Smilow Cancer Hospital Care Center at Saint Francis"
        },
        {
          "city": "New Haven",
          "country": "United States",
          "facility": "Smilow Cancer Center/Yale-New Haven Hospital"
        },
        {
          "city": "New Haven",
          "country": "United States",
          "facility": "Yale University"
        },
        {
          "city": "North Haven",
          "country": "United States",
          "facility": "Yale-New Haven Hospital North Haven Medical Center"
        },
        {
          "city": "Torrington",
          "country": "United States",
          "facility": "Smilow Cancer Hospital-Torrington Care Center"
        },
        {
          "city": "Trumbull",
          "country": "United States",
          "facility": "Smilow Cancer Hospital Care Center-Trumbull"
        },
        {
          "city": "Waterbury",
          "country": "United States",
          "facility": "Smilow Cancer Hospital-Waterbury Care Center"
        },
        {
          "city": "Waterford",
          "country": "United States",
          "facility": "Smilow Cancer Hospital Care Center - Waterford"
        },
        {
          "city": "Frankford",
          "country": "United States",
          "facility": "Beebe South Coastal Health Campus"
        },
        {
          "city": "Lewes",
          "country": "United States",
          "facility": "Beebe Medical Center"
        },
        {
          "city": "Newark",
          "country": "United States",
          "facility": "Delaware Clinical and Laboratory Physicians PA"
        },
        {
          "city": "Newark",
          "country": "United States",
          "facility": "Helen F Graham Cancer Center"
        },
        {
          "city": "Newark",
          "country": "United States",
          "facility": "Medical Oncology Hematology Consultants PA"
        },
        {
          "city": "Newark",
          "country": "United States",
          "facility": "Christiana Care Health System-Christiana Hospital"
        },
        {
          "city": "Rehoboth Beach",
          "country": "United States",
          "facility": "Beebe Health Campus"
        },
        {
          "city": "Seaford",
          "country": "United States",
          "facility": "TidalHealth Nanticoke / Allen Cancer Center"
        },
        {
          "city": "Wilmington",
          "country": "United States",
          "facility": "Christiana Care Health System-Wilmington Hospital"
        },
        {
          "city": "Boise",
          "country": "United States",
          "facility": "Saint Alphonsus Cancer Care Center-Boise"
        },
        {
          "city": "Caldwell",
          "country": "United States",
          "facility": "Saint Alphonsus Cancer Care Center-Caldwell"
        },
        {
          "city": "Coeur d'Alene",
          "country": "United States",
          "facility": "Kootenai Health - Coeur d'Alene"
        },
        {
          "city": "Emmett",
          "country": "United States",
          "facility": "Walter Knox Memorial Hospital"
        },
        {
          "city": "Meridian",
          "country": "United States",
          "facility": "Idaho Urologic Institute-Meridian"
        },
        {
          "city": "Nampa",
          "country": "United States",
          "facility": "Saint Alphonsus Cancer Care Center-Nampa"
        },
        {
          "city": "Post Falls",
          "country": "United States",
          "facility": "Kootenai Clinic Cancer Services - Post Falls"
        },
        {
          "city": "Sandpoint",
          "country": "United States",
          "facility": "Kootenai Clinic Cancer Services - Sandpoint"
        },
        {
          "city": "Alton",
          "country": "United States",
          "facility": "Saint Anthony's Health"
        },
        {
          "city": "Aurora",
          "country": "United States",
          "facility": "Rush - Copley Medical Center"
        },
        {
          "city": "Bloomington",
          "country": "United States",
          "facility": "Illinois CancerCare-Bloomington"
        },
        {
          "city": "Canton",
          "country": "United States",
          "facility": "Illinois CancerCare-Canton"
        },
        {
          "city": "Carbondale",
          "country": "United States",
          "facility": "Memorial Hospital of Carbondale"
        },
        {
          "city": "Carterville",
          "country": "United States",
          "facility": "SIH Cancer Institute"
        },
        {
          "city": "Carthage",
          "country": "United States",
          "facility": "Illinois CancerCare-Carthage"
        },
        {
          "city": "Centralia",
          "country": "United States",
          "facility": "Centralia Oncology Clinic"
        },
        {
          "city": "Centralia",
          "country": "United States",
          "facility": "Saint Mary's Hospital"
        },
        {
          "city": "Chicago",
          "country": "United States",
          "facility": "Northwestern University"
        },
        {
          "city": "Chicago",
          "country": "United States",
          "facility": "University of Illinois"
        },
        {
          "city": "Danville",
          "country": "United States",
          "facility": "Carle at The Riverfront"
        },
        {
          "city": "Decatur",
          "country": "United States",
          "facility": "Cancer Care Specialists of Illinois - Decatur"
        },
        {
          "city": "Decatur",
          "country": "United States",
          "facility": "Decatur Memorial Hospital"
        },
        {
          "city": "Dixon",
          "country": "United States",
          "facility": "Illinois CancerCare-Dixon"
        },
        {
          "city": "Effingham",
          "country": "United States",
          "facility": "Carle Physician Group-Effingham"
        },
        {
          "city": "Effingham",
          "country": "United States",
          "facility": "Crossroads Cancer Center"
        },
        {
          "city": "Eureka",
          "country": "United States",
          "facility": "Illinois CancerCare-Eureka"
        },
        {
          "city": "Galesburg",
          "country": "United States",
          "facility": "Illinois CancerCare-Galesburg"
        },
        {
          "city": "Galesburg",
          "country": "United States",
          "facility": "Western Illinois Cancer Treatment Center"
        },
        {
          "city": "Kewanee",
          "country": "United States",
          "facility": "Illinois CancerCare-Kewanee Clinic"
        },
        {
          "city": "Lake Forest",
          "country": "United States",
          "facility": "Northwestern Medicine Lake Forest Hospital"
        },
        {
          "city": "Macomb",
          "country": "United States",
          "facility": "Illinois CancerCare-Macomb"
        },
        {
          "city": "Mattoon",
          "country": "United States",
          "facility": "Carle Physician Group-Mattoon/Charleston"
        },
        {
          "city": "Mount Vernon",
          "country": "United States",
          "facility": "Good Samaritan Regional Health Center"
        },
        {
          "city": "O'Fallon",
          "country": "United States",
          "facility": "Cancer Care Center of O'Fallon"
        },
        {
          "city": "Ottawa",
          "country": "United States",
          "facility": "Illinois CancerCare-Ottawa Clinic"
        },
        {
          "city": "Pekin",
          "country": "United States",
          "facility": "Illinois CancerCare-Pekin"
        },
        {
          "city": "Peoria",
          "country": "United States",
          "facility": "Illinois CancerCare-Peoria"
        },
        {
          "city": "Peoria",
          "country": "United States",
          "facility": "Methodist Medical Center of Illinois"
        },
        {
          "city": "Peru",
          "country": "United States",
          "facility": "Illinois CancerCare-Peru"
        },
        {
          "city": "Peru",
          "country": "United States",
          "facility": "Valley Radiation Oncology"
        },
        {
          "city": "Princeton",
          "country": "United States",
          "facility": "Illinois CancerCare-Princeton"
        },
        {
          "city": "Springfield",
          "country": "United States",
          "facility": "Southern Illinois University School of Medicine"
        },
        {
          "city": "Springfield",
          "country": "United States",
          "facility": "Springfield Clinic"
        },
        {
          "city": "Springfield",
          "country": "United States",
          "facility": "Memorial Medical Center"
        },
        {
          "city": "Swansea",
          "country": "United States",
          "facility": "Southwest Illinois Health Services LLP"
        },
        {
          "city": "Urbana",
          "country": "United States",
          "facility": "Carle Cancer Center"
        },
        {
          "city": "Urbana",
          "country": "United States",
          "facility": "The Carle Foundation Hospital"
        },
        {
          "city": "Washington",
          "country": "United States",
          "facility": "Illinois CancerCare - Washington"
        },
        {
          "city": "Yorkville",
          "country": "United States",
          "facility": "Rush-Copley Healthcare Center"
        },
        {
          "city": "Ames",
          "country": "United States",
          "facility": "Mary Greeley Medical Center"
        },
        {
          "city": "Ames",
          "country": "United States",
          "facility": "McFarland Clinic - Ames"
        },
        {
          "city": "Ankeny",
          "country": "United States",
          "facility": "Mission Cancer and Blood - Ankeny"
        },
        {
          "city": "Boone",
          "country": "United States",
          "facility": "McFarland Clinic - Boone"
        },
        {
          "city": "Carroll",
          "country": "United States",
          "facility": "Saint Anthony Regional Hospital"
        },
        {
          "city": "Clive",
          "country": "United States",
          "facility": "Mercy Cancer Center-West Lakes"
        },
        {
          "city": "Clive",
          "country": "United States",
          "facility": "Mission Cancer and Blood - West Des Moines"
        },
        {
          "city": "Council Bluffs",
          "country": "United States",
          "facility": "Alegent Health Mercy Hospital"
        },
        {
          "city": "Creston",
          "country": "United States",
          "facility": "Greater Regional Medical Center"
        },
        {
          "city": "Des Moines",
          "country": "United States",
          "facility": "Iowa Methodist Medical Center"
        },
        {
          "city": "Des Moines",
          "country": "United States",
          "facility": "Mission Cancer and Blood - Des Moines"
        },
        {
          "city": "Des Moines",
          "country": "United States",
          "facility": "Broadlawns Medical Center"
        },
        {
          "city": "Des Moines",
          "country": "United States",
          "facility": "Mercy Medical Center - Des Moines"
        },
        {
          "city": "Des Moines",
          "country": "United States",
          "facility": "Mission Cancer and Blood - Laurel"
        },
        {
          "city": "Des Moines",
          "country": "United States",
          "facility": "Iowa Lutheran Hospital"
        },
        {
          "city": "Fort Dodge",
          "country": "United States",
          "facility": "McFarland Clinic - Trinity Cancer Center"
        },
        {
          "city": "Fort Dodge",
          "country": "United States",
          "facility": "Trinity Regional Medical Center"
        },
        {
          "city": "Jefferson",
          "country": "United States",
          "facility": "McFarland Clinic - Jefferson"
        },
        {
          "city": "Marshalltown",
          "country": "United States",
          "facility": "McFarland Clinic - Marshalltown"
        },
        {
          "city": "West Des Moines",
          "country": "United States",
          "facility": "Methodist West Hospital"
        },
        {
          "city": "West Des Moines",
          "country": "United States",
          "facility": "Mercy Medical Center-West Lakes"
        },
        {
          "city": "Garden City",
          "country": "United States",
          "facility": "Central Care Cancer Center - Garden City"
        },
        {
          "city": "Great Bend",
          "country": "United States",
          "facility": "Central Care Cancer Center - Great Bend"
        },
        {
          "city": "Lawrence",
          "country": "United States",
          "facility": "Lawrence Memorial Hospital"
        },
        {
          "city": "Wichita",
          "country": "United States",
          "facility": "Cancer Center of Kansas-Wichita Medical Arts Tower"
        },
        {
          "city": "Wichita",
          "country": "United States",
          "facility": "Ascension Via Christi Hospitals Wichita"
        },
        {
          "city": "Wichita",
          "country": "United States",
          "facility": "Cancer Center of Kansas - Wichita"
        },
        {
          "city": "Wichita",
          "country": "United States",
          "facility": "Wesley Medical Center"
        },
        {
          "city": "Bardstown",
          "country": "United States",
          "facility": "Flaget Memorial Hospital"
        },
        {
          "city": "Corbin",
          "country": "United States",
          "facility": "Commonwealth Cancer Center-Corbin"
        },
        {
          "city": "Lexington",
          "country": "United States",
          "facility": "Saint Joseph Hospital"
        },
        {
          "city": "Lexington",
          "country": "United States",
          "facility": "Saint Joseph Radiation Oncology Resource Center"
        },
        {
          "city": "Lexington",
          "country": "United States",
          "facility": "Saint Joseph Hospital East"
        },
        {
          "city": "London",
          "country": "United States",
          "facility": "Saint Joseph London"
        },
        {
          "city": "Louisville",
          "country": "United States",
          "facility": "Jewish Hospital"
        },
        {
          "city": "Louisville",
          "country": "United States",
          "facility": "Saints Mary and Elizabeth Hospital"
        },
        {
          "city": "Louisville",
          "country": "United States",
          "facility": "UofL Health Medical Center Northeast"
        },
        {
          "city": "Mount Sterling",
          "country": "United States",
          "facility": "Saint Joseph Mount Sterling"
        },
        {
          "city": "Paducah",
          "country": "United States",
          "facility": "Mercy Health - Paducah Medical Oncology and Hematology"
        },
        {
          "city": "Shepherdsville",
          "country": "United States",
          "facility": "Jewish Hospital Medical Center South"
        },
        {
          "city": "Baltimore",
          "country": "United States",
          "facility": "Saint Agnes Hospital"
        },
        {
          "city": "Adrian",
          "country": "United States",
          "facility": "Hickman Cancer Center"
        },
        {
          "city": "Monroe",
          "country": "United States",
          "facility": "Toledo Clinic Cancer Centers-Monroe"
        },
        {
          "city": "Rochester",
          "country": "United States",
          "facility": "Mayo Clinic in Rochester"
        },
        {
          "city": "Saint Cloud",
          "country": "United States",
          "facility": "Coborn Cancer Center at Saint Cloud Hospital"
        },
        {
          "city": "Ballwin",
          "country": "United States",
          "facility": "Saint Louis Cancer and Breast Institute-Ballwin"
        },
        {
          "city": "Bolivar",
          "country": "United States",
          "facility": "Central Care Cancer Center - Bolivar"
        },
        {
          "city": "Bonne Terre",
          "country": "United States",
          "facility": "Parkland Health Center-Bonne Terre"
        },
        {
          "city": "Branson",
          "country": "United States",
          "facility": "Cox Cancer Center Branson"
        },
        {
          "city": "Cape Girardeau",
          "country": "United States",
          "facility": "Saint Francis Medical Center"
        },
        {
          "city": "Cape Girardeau",
          "country": "United States",
          "facility": "Southeast Cancer Center"
        },
        {
          "city": "Chesterfield",
          "country": "United States",
          "facility": "Saint Luke's Hospital"
        },
        {
          "city": "Farmington",
          "country": "United States",
          "facility": "Parkland Health Center - Farmington"
        },
        {
          "city": "Jefferson City",
          "country": "United States",
          "facility": "MU Health Care Goldschmidt Cancer Center"
        },
        {
          "city": "Joplin",
          "country": "United States",
          "facility": "Freeman Health System"
        },
        {
          "city": "Joplin",
          "country": "United States",
          "facility": "Mercy Hospital Joplin"
        },
        {
          "city": "Osage Beach",
          "country": "United States",
          "facility": "Lake Regional Hospital"
        },
        {
          "city": "Rolla",
          "country": "United States",
          "facility": "Delbert Day Cancer Institute at PCRMC"
        },
        {
          "city": "Rolla",
          "country": "United States",
          "facility": "Mercy Clinic-Rolla-Cancer and Hematology"
        },
        {
          "city": "Saint Joseph",
          "country": "United States",
          "facility": "Heartland Regional Medical Center"
        },
        {
          "city": "Sainte Genevieve",
          "country": "United States",
          "facility": "Sainte Genevieve County Memorial Hospital"
        },
        {
          "city": "Springfield",
          "country": "United States",
          "facility": "Mercy Hospital Springfield"
        },
        {
          "city": "Springfield",
          "country": "United States",
          "facility": "CoxHealth South Hospital"
        },
        {
          "city": "St Louis",
          "country": "United States",
          "facility": "Saint Louis Cancer and Breast Institute-South City"
        },
        {
          "city": "St Louis",
          "country": "United States",
          "facility": "Mercy Hospital South"
        },
        {
          "city": "St Louis",
          "country": "United States",
          "facility": "Missouri Baptist Medical Center"
        },
        {
          "city": "St Louis",
          "country": "United States",
          "facility": "Mercy Hospital Saint Louis"
        },
        {
          "city": "Sullivan",
          "country": "United States",
          "facility": "Missouri Baptist Sullivan Hospital"
        },
        {
          "city": "Sunset Hills",
          "country": "United States",
          "facility": "BJC Outpatient Center at Sunset Hills"
        },
        {
          "city": "Washington",
          "country": "United States",
          "facility": "Mercy Hospital Washington"
        },
        {
          "city": "Anaconda",
          "country": "United States",
          "facility": "Community Hospital of Anaconda"
        },
        {
          "city": "Billings",
          "country": "United States",
          "facility": "Billings Clinic Cancer Center"
        },
        {
          "city": "Bozeman",
          "country": "United States",
          "facility": "Bozeman Health Deaconess Hospital"
        },
        {
          "city": "Great Falls",
          "country": "United States",
          "facility": "Benefis Sletten Cancer Institute"
        },
        {
          "city": "Great Falls",
          "country": "United States",
          "facility": "Great Falls Clinic"
        },
        {
          "city": "Helena",
          "country": "United States",
          "facility": "Saint Peter's Community Hospital"
        },
        {
          "city": "Kalispell",
          "country": "United States",
          "facility": "Kalispell Regional Medical Center"
        },
        {
          "city": "Missoula",
          "country": "United States",
          "facility": "Community Medical Center"
        },
        {
          "city": "Bellevue",
          "country": "United States",
          "facility": "Nebraska Medicine-Bellevue"
        },
        {
          "city": "Grand Island",
          "country": "United States",
          "facility": "Nebraska Cancer Specialists/Oncology Hematology West PC"
        },
        {
          "city": "Kearney",
          "country": "United States",
          "facility": "Heartland Hematology and Oncology"
        },
        {
          "city": "Kearney",
          "country": "United States",
          "facility": "CHI Health Good Samaritan"
        },
        {
          "city": "Lincoln",
          "country": "United States",
          "facility": "Saint Elizabeth Regional Medical Center"
        },
        {
          "city": "Omaha",
          "country": "United States",
          "facility": "Nebraska Medicine-Village Pointe"
        },
        {
          "city": "Omaha",
          "country": "United States",
          "facility": "Alegent Health Immanuel Medical Center"
        },
        {
          "city": "Omaha",
          "country": "United States",
          "facility": "Hematology and Oncology Consultants PC"
        },
        {
          "city": "Omaha",
          "country": "United States",
          "facility": "Alegent Health Bergan Mercy Medical Center"
        },
        {
          "city": "Omaha",
          "country": "United States",
          "facility": "Alegent Health Lakeside Hospital"
        },
        {
          "city": "Omaha",
          "country": "United States",
          "facility": "Creighton University Medical Center"
        },
        {
          "city": "Omaha",
          "country": "United States",
          "facility": "University of Nebraska Medical Center"
        },
        {
          "city": "Papillion",
          "country": "United States",
          "facility": "Midlands Community Hospital"
        },
        {
          "city": "Morristown",
          "country": "United States",
          "facility": "Morristown Medical Center"
        },
        {
          "city": "Summit",
          "country": "United States",
          "facility": "Overlook Hospital"
        },
        {
          "city": "Middletown",
          "country": "United States",
          "facility": "Garnet Health Medical Center"
        },
        {
          "city": "Clinton",
          "country": "United States",
          "facility": "Southeastern Medical Oncology Center-Clinton"
        },
        {
          "city": "Goldsboro",
          "country": "United States",
          "facility": "Southeastern Medical Oncology Center-Goldsboro"
        },
        {
          "city": "Goldsboro",
          "country": "United States",
          "facility": "Wayne Memorial Hospital"
        },
        {
          "city": "Jacksonville",
          "country": "United States",
          "facility": "Onslow Memorial Hospital"
        },
        {
          "city": "Jacksonville",
          "country": "United States",
          "facility": "Southeastern Medical Oncology Center-Jacksonville"
        },
        {
          "city": "Cincinnati",
          "country": "United States",
          "facility": "Good Samaritan Hospital - Cincinnati"
        },
        {
          "city": "Cincinnati",
          "country": "United States",
          "facility": "Bethesda North Hospital"
        },
        {
          "city": "Cincinnati",
          "country": "United States",
          "facility": "TriHealth Cancer Institute-Westside"
        },
        {
          "city": "Cincinnati",
          "country": "United States",
          "facility": "TriHealth Cancer Institute-Anderson"
        },
        {
          "city": "Cleveland",
          "country": "United States",
          "facility": "MetroHealth Medical Center"
        },
        {
          "city": "Maumee",
          "country": "United States",
          "facility": "Toledo Clinic Cancer Centers-Maumee"
        },
        {
          "city": "Perrysburg",
          "country": "United States",
          "facility": "Mercy Health Perrysburg Cancer Center"
        },
        {
          "city": "Toledo",
          "country": "United States",
          "facility": "Mercy Health - Saint Anne Hospital"
        },
        {
          "city": "Toledo",
          "country": "United States",
          "facility": "Toledo Clinic Cancer Centers-Toledo"
        },
        {
          "city": "Lawton",
          "country": "United States",
          "facility": "Cancer Centers of Southwest Oklahoma Research"
        },
        {
          "city": "Oklahoma City",
          "country": "United States",
          "facility": "University of Oklahoma Health Sciences Center"
        },
        {
          "city": "Oklahoma City",
          "country": "United States",
          "facility": "Mercy Hospital Oklahoma City"
        },
        {
          "city": "Tulsa",
          "country": "United States",
          "facility": "Oklahoma Cancer Specialists and Research Institute-Tulsa"
        },
        {
          "city": "Baker City",
          "country": "United States",
          "facility": "Saint Alphonsus Cancer Care Center-Baker City"
        },
        {
          "city": "Ontario",
          "country": "United States",
          "facility": "Saint Alphonsus Cancer Care Center-Ontario"
        },
        {
          "city": "Chadds Ford",
          "country": "United States",
          "facility": "Christiana Care Health System-Concord Health Center"
        },
        {
          "city": "Danville",
          "country": "United States",
          "facility": "Geisinger Medical Center"
        },
        {
          "city": "Hazleton",
          "country": "United States",
          "facility": "Geisinger Medical Center-Cancer Center Hazleton"
        },
        {
          "city": "Lewisburg",
          "country": "United States",
          "facility": "Geisinger Medical Oncology-Lewisburg"
        },
        {
          "city": "Lewistown",
          "country": "United States",
          "facility": "Lewistown Hospital"
        },
        {
          "city": "Pottsville",
          "country": "United States",
          "facility": "Geisinger Cancer Services-Pottsville"
        },
        {
          "city": "Scranton",
          "country": "United States",
          "facility": "Community Medical Center"
        },
        {
          "city": "Selinsgrove",
          "country": "United States",
          "facility": "Geisinger Medical Oncology-Selinsgrove"
        },
        {
          "city": "State College",
          "country": "United States",
          "facility": "Geisinger Medical Group"
        },
        {
          "city": "Wilkes-Barre",
          "country": "United States",
          "facility": "Geisinger Wyoming Valley/Henry Cancer Center"
        },
        {
          "city": "Boiling Springs",
          "country": "United States",
          "facility": "Prisma Health Cancer Institute - Spartanburg"
        },
        {
          "city": "Clinton",
          "country": "United States",
          "facility": "Prisma Health Cancer Institute - Laurens"
        },
        {
          "city": "Easley",
          "country": "United States",
          "facility": "Prisma Health Cancer Institute - Easley"
        },
        {
          "city": "Greenville",
          "country": "United States",
          "facility": "BI-LO Charities Children's Cancer Center"
        },
        {
          "city": "Greenville",
          "country": "United States",
          "facility": "Prisma Health Cancer Institute - Butternut"
        },
        {
          "city": "Greenville",
          "country": "United States",
          "facility": "Prisma Health Cancer Institute - Faris"
        },
        {
          "city": "Greenville",
          "country": "United States",
          "facility": "Prisma Health Greenville Memorial Hospital"
        },
        {
          "city": "Greenville",
          "country": "United States",
          "facility": "Prisma Health Cancer Institute - Eastside"
        },
        {
          "city": "Greer",
          "country": "United States",
          "facility": "Prisma Health Cancer Institute - Greer"
        },
        {
          "city": "Seneca",
          "country": "United States",
          "facility": "Prisma Health Cancer Institute - Seneca"
        },
        {
          "city": "Chattanooga",
          "country": "United States",
          "facility": "Memorial Hospital"
        },
        {
          "city": "Franklin",
          "country": "United States",
          "facility": "Vanderbilt-Ingram Cancer Center Cool Springs"
        },
        {
          "city": "Hixson",
          "country": "United States",
          "facility": "Pulmonary Medicine Center of Chattanooga-Hixson"
        },
        {
          "city": "Nashville",
          "country": "United States",
          "facility": "Vanderbilt Breast Center at One Hundred Oaks"
        },
        {
          "city": "Nashville",
          "country": "United States",
          "facility": "Vanderbilt University/Ingram Cancer Center"
        },
        {
          "city": "Ooltewah",
          "country": "United States",
          "facility": "Memorial GYN Plus"
        },
        {
          "city": "Bryan",
          "country": "United States",
          "facility": "Saint Joseph Regional Cancer Center"
        },
        {
          "city": "Martinsville",
          "country": "United States",
          "facility": "Sovah Health Martinsville"
        },
        {
          "city": "Bremerton",
          "country": "United States",
          "facility": "Harrison HealthPartners Hematology and Oncology-Bremerton"
        },
        {
          "city": "Burien",
          "country": "United States",
          "facility": "Highline Medical Center-Main Campus"
        },
        {
          "city": "Enumclaw",
          "country": "United States",
          "facility": "Saint Elizabeth Hospital"
        },
        {
          "city": "Federal Way",
          "country": "United States",
          "facility": "Saint Francis Hospital"
        },
        {
          "city": "Lakewood",
          "country": "United States",
          "facility": "Saint Clare Hospital"
        },
        {
          "city": "Port Townsend",
          "country": "United States",
          "facility": "Jefferson Healthcare"
        },
        {
          "city": "Poulsbo",
          "country": "United States",
          "facility": "Harrison HealthPartners Hematology and Oncology-Poulsbo"
        },
        {
          "city": "Silverdale",
          "country": "United States",
          "facility": "Saint Michael Cancer Center"
        },
        {
          "city": "Tacoma",
          "country": "United States",
          "facility": "Franciscan Research Center-Northwest Medical Plaza"
        },
        {
          "city": "Tacoma",
          "country": "United States",
          "facility": "Northwest Medical Specialties PLLC"
        },
        {
          "city": "Morgantown",
          "country": "United States",
          "facility": "West Virginia University Healthcare"
        },
        {
          "city": "Appleton",
          "country": "United States",
          "facility": "ThedaCare Regional Cancer Center"
        },
        {
          "city": "Eau Claire",
          "country": "United States",
          "facility": "Marshfield Medical Center-EC Cancer Center"
        },
        {
          "city": "Eau Claire",
          "country": "United States",
          "facility": "Mayo Clinic Health System-Eau Claire Clinic"
        },
        {
          "city": "Eau Claire",
          "country": "United States",
          "facility": "Mayo Clinic Health System Eau Claire Hospital-Luther Campus"
        },
        {
          "city": "Ladysmith",
          "country": "United States",
          "facility": "Marshfield Medical Center - Ladysmith"
        },
        {
          "city": "Marshfield",
          "country": "United States",
          "facility": "Marshfield Medical Center-Marshfield"
        },
        {
          "city": "Milwaukee",
          "country": "United States",
          "facility": "Medical College of Wisconsin"
        },
        {
          "city": "Minocqua",
          "country": "United States",
          "facility": "Marshfield Clinic-Minocqua Center"
        },
        {
          "city": "New Berlin",
          "country": "United States",
          "facility": "Froedtert and MCW Moorland Reserve Health Center"
        },
        {
          "city": "Rice Lake",
          "country": "United States",
          "facility": "Marshfield Medical Center-Rice Lake"
        },
        {
          "city": "Stevens Point",
          "country": "United States",
          "facility": "Marshfield Medical Center-River Region at Stevens Point"
        },
        {
          "city": "Wausau",
          "country": "United States",
          "facility": "Marshfield Clinic-Wausau Center"
        },
        {
          "city": "Weston",
          "country": "United States",
          "facility": "Marshfield Medical Center - Weston"
        },
        {
          "city": "Wisconsin Rapids",
          "country": "United States",
          "facility": "Marshfield Clinic - Wisconsin Rapids Center"
        },
        {
          "city": "Cheyenne",
          "country": "United States",
          "facility": "Cheyenne Regional Medical Center-West"
        },
        {
          "city": "Cody",
          "country": "United States",
          "facility": "Billings Clinic-Cody"
        },
        {
          "city": "Sheridan",
          "country": "United States",
          "facility": "Welch Cancer Center"
        }
      ],
      "outcomes": {
        "other": [],
        "primary": [
          "Proportion of patients on tyrosine kinase inhibitor (TKI) who convert to undetectable minimal residual disease (UMRD)"
        ],
        "secondary": [
          "Proportion of patients who maintain UMRD for 6 months",
          "Proportion of patients who maintain UMRD for 6 and 12 months",
          "Proportion of patients who meet the criteria for discontinuing TKI",
          "Proportion of patients who maintain UMRD for 2 years after first achieving UMRD",
          "Proportion of patients who develop grade 3 or 4 immune related adverse events (not including grade 3 events that respond to corticosteroids and improve to grade 1 or less within 4 weeks)"
        ]
      },
      "eligibility": {
        "sex": "ALL",
        "criteria": "Inclusion Criteria:\n\n* PREREGISTRATION (STEP 0): Patient has pathologically-confirmed chronic phase-CML on a first line TKI and must meet the following criteria:\n\n  * The patient has to be on first-line TKI therapy (the same TKI) for at least 2 years prior to pre-registration\n  * Has been in MMR (i.e. MR\\^3) but still have detectable BCR-ABL transcript by a standard real-time quantitative polymerase chain reaction (RQ-PCR) assay with a limit of detection (sensitivity) of 4.5 for at least 12 months from the first documentation of the MMR\n  * Patient has not achieved MR\\^4.5 (complete molecular remission \\[CMR\\]) within the time of initiation of TKI therapy and pre-registration\n* PREREGISTRATION (STEP 0): Patient must be scheduled to undergo a standard of care bone marrow biopsy within 7 days of step 0 registration\n* PREREGISTRATION (STEP 0): Peripheral blood must be collected for submission to Fred Hutchinson Cancer Research Center for central assessment of the establishment of BCR/ABL status to confirm patient?s eligibility for registration to Step 1; Fred Hutchinson will forward results within 1-2 business days of receipt of the peripheral blood to the submitting institution\n* REGISTRATION TO TREATMENT (STEP 1): Institution has received central BCR-ABL test results confirming MRD positive status\n* REGISTRATION TO TREATMENT (STEP 1): Patients have an Eastern Cooperative Oncology Group (ECOG) performance status of 0-1\n* REGISTRATION TO TREATMENT (STEP 1): No active hemolytic anemia requiring immunosuppressive therapy or other pharmacologic treatment; patients who have a positive Coombs test but no evidence of hemolysis are NOT excluded from participation\n* REGISTRATION TO TREATMENT (STEP 1): No current use of corticosteroids; EXCEPTION: Low doses of steroids (\\< 10 mg of prednisone or equivalent dose of other steroid) used for treatment of non-hematologic medical condition (e.g. chronic adrenal insufficiency) is permitted\n* REGISTRATION TO TREATMENT (STEP 1): No other active primary malignancy (other than non-melanomatous skin cancer or carcinoma in situ of the cervix) requiring treatment or limiting expected survival to =\\< 2 years\n\n  * NOTE: If there is a history of prior malignancy, they must not be receiving other specific treatment (other than hormonal therapy for their cancer)\n* REGISTRATION TO TREATMENT (STEP 1): Women must not be pregnant or breastfeeding; patients must also not expect to conceive or father children from the time of registration, while on study treatment, and continue for 120 days after the last dose of study treatment; all females of childbearing potential must have a negative urine or serum pregnancy within 72 hours prior to receiving the first dose of pembrolizumab; if the urine test is positive or cannot be confirmed as negative, a serum pregnancy test will be required; a female of childbearing potential is any woman, regardless of sexual orientation or whether they have undergone tubal ligation, who meets the following criteria: 1) has not undergone a hysterectomy or bilateral oophorectomy; or 2) has not been naturally postmenopausal for at least 24 consecutive months (i.e., has had menses at any time in the preceding 24 consecutive months)\n* REGISTRATION TO TREATMENT (STEP 1): Women of childbearing potential and sexually active males must use an accepted and effective method of contraception or to abstain from sexual from time of registration, while on study treatment, and continue for 120 days after the last dose of study treatment\n* REGISTRATION TO TREATMENT (STEP 1): Patients must have been on a stable dose of the TKI for the last 3 months prior to pre-registration\n* REGISTRATION TO TREATMENT (STEP 1): Patient may not be currently participating and receiving study therapy or have participated in a study of an investigational agent and received study therapy or used an investigational device within 4 weeks of the first dose of treatment\n* REGISTRATION TO TREATMENT (STEP 1): Patient must not have a diagnosis of immunodeficiency or be receiving systemic steroid therapy or any other form of immunosuppressive therapy within 7 days prior to the first dose of treatment\n* REGISTRATION TO TREATMENT (STEP 1): Patient must not have a known history of active TB (Bacillus Tuberculosis)\n* REGISTRATION TO TREATMENT (STEP 1): Patient must not have a history of hypersensitivity to pembrolizumab or any of its excipients\n* REGISTRATION TO TREATMENT (STEP 1): Patient must not have received a prior anti-cancer monoclonal antibody (mAb) within 4 weeks prior to study registration or have not recovered (i.e., =\\< grade 1 or at baseline) from adverse events due to agents administered more than 4 weeks earlier\n* REGISTRATION TO TREATMENT (STEP 1): Patient must not have had prior chemotherapy, targeted small molecule therapy (aside from imatinib, dasatinib, or nilotinib), or radiation therapy within 2 weeks prior to study registration; patients also must have recovered from all adverse events due to a previously administered agent\n\n  * Note: Patients with =\\< grade 2 neuropathy are an exception to this criterion and may qualify for the study\n* REGISTRATION TO TREATMENT (STEP 1): Patients who have received major surgery must have recovered adequately from the toxicity and/or complications from the intervention prior to starting therapy\n* REGISTRATION TO TREATMENT (STEP 1): Patient must not have a known additional malignancy that is progressing or requires active treatment; exceptions include basal cell carcinoma of the skin or squamous cell carcinoma of the skin that has undergone potentially curative therapy or in situ cervical cancer\n* REGISTRATION TO TREATMENT (STEP 1): Patient must not have known active central nervous system (CNS) metastases and/or carcinomatous meningitis; subjects with previously treated brain metastases may participate provided they are stable (without evidence of progression by imaging for at least four weeks prior to the first dose of protocol treatment and any neurologic symptoms have returned to baseline), have no evidence of new or enlarging brain metastases, and are not using steroids for at least 7 days prior to protocol treatment; this exception does not include carcinomatous meningitis which is excluded regardless of clinical stability\n* REGISTRATION TO TREATMENT (STEP 1): Patient must not have active autoimmune disease that has required systemic treatment in the past 2 years (i.e. with use of disease modifying agents, corticosteroids or immunosuppressive drugs); replacement therapy (e.g., thyroxine, insulin, or physiologic corticosteroid replacement therapy for adrenal or pituitary insufficiency, etc.) is not considered a form of systemic treatment\n* REGISTRATION TO TREATMENT (STEP 1): Patient must not have known history of, or any evidence of active, non-infectious pneumonitis\n* REGISTRATION TO TREATMENT (STEP 1): Patient must not have an active infection requiring systemic therapy\n* REGISTRATION TO TREATMENT (STEP 1): Patient must not have a history or current evidence of any condition, therapy, or laboratory abnormality that might confound the results of the trial, interfere with the subject's participation for the full duration of the trial, or is not in the best interest of the subject to participate, in the opinion of the treating investigator\n* REGISTRATION TO TREATMENT (STEP 1): Patient must not have known psychiatric or substance abuse disorders that would interfere with cooperation with the requirements of the trial\n* REGISTRATION TO TREATMENT (STEP 1): Patient must not have received prior therapy with an anti-PD-1, anti-PD-L1, or anti-PD-L2 agent\n* REGISTRATION TO TREATMENT (STEP 1): Patients who are Human Immunodeficiency Virus (HIV) positive are eligible if they have undetectable HIV viral load and CD4+ T-cell count ≥ 250/mm3.\n* REGISTRATION TO TREATMENT (STEP 1): Patients with a known positive test for Hepatitis C virus ribonucleic acid (HCV antibody) indicating acute or chronic infection might be enrolled if the viral load by PCR is undetectable with/without active treatment.\n* REGISTRATION TO TREATMENT (STEP 1): Patients must not have known history of hepatitis B (defined as Hepatitis B surface antigen \\[HBsAg\\] reactive).\n* REGISTRATION TO TREATMENT (STEP 1): Patient must not have received a live vaccine within 30 days of planned start of study therapy\n\n  * NOTE: Seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines, and are not allowed\n* REGISTRATION TO TREATMENT (STEP 1): Absolute neutrophil count (ANC) \\>= 1,500 /mcL, within 14 days prior to first dose of pembrolizumab\n* REGISTRATION TO TREATMENT (STEP 1): Platelet count \\>= 100,000 /mcL, within 14 days prior to first dose of pembrolizumab\n* REGISTRATION TO TREATMENT (STEP 1): Hemoglobin (Hgb) \\>= 9 g/dL OR \\>= 5.6 mmol/L without transfusion of erythropoietin (EPO) dependency, within 14 days prior to first dose of pembrolizumab\n* REGISTRATION TO TREATMENT (STEP 1): Serum creatinine =\\< 1.5 X upper limit of normal (ULN) OR creatinine clearance (per institutional standards) \\>= 60 mL/min for patient with creatinine levels \\> 1.5 X ULN, within 14 days prior to first dose of pembrolizumab\n* REGISTRATION TO TREATMENT (STEP 1): Serum total bilirubin =\\< 1.5 X ULN OR direct bilirubin\n\n  =\\< ULN for subjects with total bilirubin levels \\> 1.5 X ULN, within 14 days prior to first dose of pembrolizumab\n* REGISTRATION TO TREATMENT (STEP 1): Aspartate aminotransferase (AST) (serum glutamic oxaloacetic transaminase \\[SGOT\\]) and alanine aminotransferase (ALT) (serum glutamic pyruvic transaminase \\[SGPT\\]) =\\< 2.5 X ULN OR =\\< 5 X ULN for subjects with liver metastases, within 14 days prior to first dose of pembrolizumab\n* REGISTRATION TO TREATMENT (STEP 1): Patients should not be receiving concomitant strong CYP3A4 inducers or inhibitors ≤ 7 days prior to registration due to their potential to effect the activity or pharmacokinetics of study agents and/or QT interval prolongation toxicity. Should treatment with any of these agents be required, consult with study chair.\n* REGISTRATION TO TREATMENT (STEP 1): Patients should not have received prior allogeneic transplant.",
        "minimumAge": "18 Years",
        "healthyVolunteers": false
      },
      "enrollment": {
        "type": "ESTIMATED",
        "count": 40
      },
      "startDate": "2019-06-26",
      "completionDate": "2031-08-31",
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