{ "data": { "asOf": "2026-10-30T22:24:26.120Z", "dedupMethod": "exact cross-registry identifier matching; probabilistic = review only", "byRegistry": { "clinicaltrials_gov": 1 }, "canonicalTrial": { "canonicalId": "NCT02417740", "title": "Natural History of Noncirrhotic Portal Hypertension", "scientificTitle": "Natural History of Noncirrhotic Portal Hypertension", "status": "recruiting", "studyType": "observational", "phase": [], "conditions": [ "Cystic Fibrosis", "Immunologic Deficiency Syndrome", "Turner Syndrome", "Congenital Hepatic Fibrosis", "Idiopathic Non-Cirrhotic Portal Hypertension" ], "interventions": [], "sponsor": { "name": "National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)", "type": "NIH" }, "locations": [ { "city": "Bethesda", "country": "United States", "facility": "National Institutes of Health Clinical Center" } ], "outcomes": { "other": [], "primary": [ "To study the natural history of non cirrhotic portal hypertension. It is an ongoing study." ], "secondary": [] }, "eligibility": { "sex": "ALL", "criteria": "* INCLUSION CRITERIA:\n\nIn order to be eligible to participate in this study, an individual must meet all of the following criteria:\n\n* Male or female, aged \\>= 18 years of age, and minors 12-17 years of age.\n* Women of childbearing potential must agree to use birth control unless they are menopausal or had hysterectomy.\n* Known diagnosis of NCPH, or to be at the risk for NCPH by virtue of underlying disease processes such as but not limited to; CGD, SCD, Mastocytosis, CVID, CF, and CHF.\n\nEXCLUSION CRITERIA:\n\nAn individual who meets any of the following criteria will be excluded from participation in this study:\n\n* Pregnancy.\n* Evidence of other forms of liver disease that typically result in cirrhosis.\n* Evidence of active Chronic Hepatitis B infection as defined by the presence of hepatitis B surface antigen (HBsAg) in serum and elevated HBV DNA (\\>10,000 IU/mL).\n* Hepatitis C as defined by the presence of hepatitis C RNA in serum.\n* Evidence of other liver disease such as primary sclerosing cholangitis, primary biliary cirrhosis, Wilson s disease, autoimmune hepatitis as defined by either liver histology or laboratory abnormalities.\n* Hemochromatosis as defined by presence of 3+ or 4+ stainable iron on liver biopsy or homozygosity for C282Y. Patients with iron saturation indices of \\>45% and serum ferritin levels of \\>300 ng/ml for men and \\>250 ng/ml for women will undergo genetic testing for hemochromatosis.\n* Bile duct obstruction as suggested by imaging studies done within the previous six months.\n* The presence of cirrhosis confirmed by liver biopsy.\n* Active substance abuse, such as alcohol, inhaled or injection drugs within the previous one year (assessed during subject interviews by subject self-report).\n* Evidence of hepatocellular carcinoma; either alpha-fetoprotein (AFP) levels greater than 50 ng/ml (normal \\<6.6ng/ml) and/or ultrasound (or other imaging study) demonstrating a mass suggestive of liver cancer.\n* Evidence of cholangiocarcinoma as suggested by liver histology.\n* Any other severe condition, which in the opinion of the investigators would impede the patient s participation or compliance in the study.\n* Inability to comply or give written informed consent.", "maximumAge": "100 Years", "minimumAge": "12 Years", "healthyVolunteers": false }, "enrollment": { "type": "ESTIMATED", "count": 400 }, "startDate": "2015-07-27", "completionDate": "2029-09-04", "lastUpdated": "2026-10-26T00:00:00.000Z", "firstPosted": "2015-04-16T00:00:00.000Z", "resultsAvailable": false, "sourceRegistries": [ "clinicaltrials_gov" ], "sourceUrls": [ "https://clinicaltrials.gov/study/NCT02417740" ] }, "identifiers": [ { "idType": "nct", "idValue": "NCT02417740", "declaredBy": "clinicaltrials_gov" } ], "sourceRecords": [ { "registry": "clinicaltrials_gov", "registryName": "ClinicalTrials.gov", "license": "public-domain", "sourceId": "NCT02417740", "sourceUrl": "https://clinicaltrials.gov/study/NCT02417740", "sourceStatus": "RECRUITING", "retrievedAt": "2026-10-28T04:32:44.628Z", "payloadSha256": "d2e2192cb0cff1d87105b9f30e2b873bc248edd6fbb695c919cc7e6b0c8181fd", "piiRedacted": true } ], "citation": { "canonicalId": "NCT02417740", "sources": [ { "registry": "clinicaltrials_gov", "registryName": "ClinicalTrials.gov", "license": "public-domain", "sourceId": "NCT02417740", "verifyAt": "https://clinicaltrials.gov/study/NCT02417740", "retrievedAt": "2026-10-28T04:32:44.628Z", "payloadSha256": "d2e2192cb0cff1d87105b9f30e2b873bc248edd6fbb695c919cc7e6b0c8181fd", "text": "ClinicalTrials.gov, record NCT02417740 (https://clinicaltrials.gov/study/NCT02417740), retrieved 2026-10-28, licence: public-domain." } ], "crossRegistry": false, "dedupMethod": "exact cross-registry identifier matching; probabilistic = review only", "text": "Trial NCT02417740, registered in ClinicalTrials.gov, retrieved 2026-10-28. Verify at the source URLs listed; each retrieval is checksummed.", "note": "Only one registry is known to hold this trial. Absence from the others is not evidence it was not registered there." }, "provenanceNote": "Personal contact fields (names, emails, phone numbers, addresses) are stripped from every stored payload. No participant-level data is collected or served." }, "_meta": { "api": "The Last Economy Wire: World Trials API", "version": "1.0", "schemaVersion": "1", "correlationId": "req_RUNHuWJ4iQuH", "generatedAt": "2026-10-30T22:24:26.120Z", "documentation": "https://negativeresistance.com/embed", "license": "Free for any use. Attribution appreciated.", "degraded": false, "provenance": { "sources": [ "clinicaltrials_gov" ], "attribution": { "clinicaltrials_gov": "ClinicalTrials.gov: licence: public-domain, https://clinicaltrials.gov/data-api/api-docs" }, "dedupMethod": "exact cross-registry identifier matching; probabilistic = review only", "limitations": [], "provenanceEndpoint": "/api/v1/sources" }, "freshness": { "newestEvidenceAt": null, "lastSyncedAt": { "clinicaltrials_gov": "2026-10-28T04:33:30.663Z" }, "degradedSources": [], "worldwide": false, "maxAgeHours": 65.8, "fromCache": false }, "links": { "discovery": "https://negativeresistance.com/api/v1", "openapi": "https://negativeresistance.com/api/v1/openapi.json", "mcp": "https://negativeresistance.com/api/v1/mcp", "agentCard": "https://negativeresistance.com/.well-known/agent.json", "aiPlugin": "https://negativeresistance.com/.well-known/ai-plugin.json", "sdk": "https://negativeresistance.com/api/v1/sdk", "status": "https://negativeresistance.com/api/v1/status", "provenance": "https://negativeresistance.com/api/v1/sources", "contract": "https://negativeresistance.com/api/v1/contract", "curriculum": "https://negativeresistance.com/api/v1/curriculum", "graph": "https://negativeresistance.com/api/v1/graph", "openQuestions": "https://negativeresistance.com/api/v1/open-questions", "scoreboard": "https://negativeresistance.com/api/v1/scoreboard", "findings": "https://negativeresistance.com/api/v1/findings", "claims": "https://negativeresistance.com/api/v1/claims", "threads": "https://negativeresistance.com/api/v1/threads", "assignment": "https://negativeresistance.com/api/v1/assignment", "changes": "https://negativeresistance.com/api/v1/changes", "hello": "https://negativeresistance.com/api/v1/hello", "errors": "https://negativeresistance.com/api/v1/errors", "webhooks": "https://negativeresistance.com/api/v1/webhooks", "a2a": "https://negativeresistance.com/api/v1/a2a", "deadEnds": "https://negativeresistance.com/api/v1/dead-ends", "decompositions": "https://negativeresistance.com/api/v1/decompositions", "rungs": "https://negativeresistance.com/api/v1/rungs", "methods": "https://negativeresistance.com/api/v1/methods", "reality": "https://negativeresistance.com/api/v1/reality", "council": "https://negativeresistance.com/api/v1/council", "calibration": "https://negativeresistance.com/api/v1/calibration", "freshness": "https://negativeresistance.com/api/v1/freshness", "mission": "https://negativeresistance.com/api/v1/mission", "twin": "https://negativeresistance.com/api/v1/twin", "twinExperiment": "https://negativeresistance.com/api/v1/twin/experiment", "betaCell": "https://negativeresistance.com/api/v1/twin/beta-cell", "patientModel": "https://negativeresistance.com/api/v1/twin/patient-model", "agentCardCanonical": "https://negativeresistance.com/.well-known/agent-card.json", "collaborate": "https://negativeresistance.com/collaborate", "manifesto": "https://negativeresistance.com/about", "documentation": "https://negativeresistance.com/embed", "connect": "https://negativeresistance.com/connect", "llmsTxt": "https://negativeresistance.com/llms.txt", "llmsFullTxt": "https://negativeresistance.com/llms-full.txt" }, "disclaimer": "Research data from public registries and literature; not medical advice." } }