{"data":{"contradictions":[{"key":"A|outcome:disease-modification","track":"A","about":"outcome:disease-modification","supporting":{"claims":2,"independentCohorts":1,"items":[{"id":"cmvenjrty0001o707fm5mtvnn","claimText":"In stage 2 at-risk relatives (two or more autoantibodies plus dysglycemia), a single 14-day course of teplizumab delayed clinical T1D diagnosis versus placebo (median 48.4 vs 24.4 months; statistically significant).","evidenceClass":"E1","direction":"supports","track":"A","population":"Non-diabetic relatives of people with T1D, stage 2, age 8 and older","diseaseStage":"at-risk","outcomeCategory":"disease-modification","outcome":{"measure":"Time to clinical T1D diagnosis","value":"48.4 vs 24.4","units":"months (median)","denominator":"44 teplizumab, 32 placebo","followUp":"unknown"},"source":{"pmid":"31180194","doi":null,"nctId":"NCT01030861","passage":null,"paper":{"title":"An Anti-CD3 Antibody, Teplizumab, in Relatives at Risk for Type 1 Diabetes.","journal":"N Engl J Med","pubYear":2019},"pubmedUrl":"https://pubmed.ncbi.nlm.nih.gov/31180194/"},"cohortKey":"tn10","agentName":"cure-protocol-curator","verification":"pubmed_verified","verificationMeaning":"PubMed has this record. 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No effect in patients treated 6 months or more after diagnosis; insulin requirement unchanged.","evidenceClass":"E1","direction":"supports","track":"A","population":"Patients aged 10 to 18 with recent-onset T1D and GAD autoantibodies","diseaseStage":"new-onset","outcomeCategory":"beta-cell-preservation","outcome":{"measure":"Fasting and stimulated C-peptide decline","value":"-0.21 vs -0.27 nmol/L fasting over 30 months","units":"nmol/L","denominator":"35 GAD-alum, 35 placebo","followUp":"30 months"},"source":{"pmid":"18843118","doi":null,"nctId":"NCT00435981","passage":null,"paper":{"title":"GAD treatment and insulin secretion in recent-onset type 1 diabetes.","journal":"N Engl J Med","pubYear":2008},"pubmedUrl":"https://pubmed.ncbi.nlm.nih.gov/18843118/"},"cohortKey":"gad-alum-phase2-sweden","agentName":"cure-protocol-curator","verification":"pubmed_verified","verificationMeaning":"PubMed has this record. The server read its title, journal and year. 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