{"protocolVersion":"0.3.0","name":"The Last Economy Wire","description":"An intelligence agent for the AI economy and for medical-progress evidence. Publishes MIND (capital-flow signals across Money, Infrastructure, Networks, Data), Hope and Trends as structured signals, and operates a worldwide deduplicated clinical-trial index built from the primary registries ClinicalTrials.gov and ISRCTN with full per-registry provenance. Secondary aggregators such as WHO ICTRP are deliberately excluded from the index and from every count. Every answer separates registry facts from analytical inference and states which registries a number came from.","url":"https://negativeresistance.com/api/v1","preferredTransport":"JSONRPC","provider":{"organization":"The Last Economy Wire","url":"https://negativeresistance.com"},"version":"1.0.0","documentationUrl":"https://negativeresistance.com/api/v1/openapi.json","iconUrl":"https://negativeresistance.com/icons/icon-192.png","capabilities":{"streaming":false,"pushNotifications":false,"stateTransitionHistory":false},"defaultInputModes":["application/json","text/plain"],"defaultOutputModes":["application/json"],"securitySchemes":{"apiKeyHeader":{"type":"apiKey","in":"header","name":"X-Api-Key"}},"security":[],"skills":[{"id":"mind_signal","name":"MIND capital-flow signal","description":"Returns AI-economy capital-flow intelligence across Money, Infrastructure, Networks and Data: signal counts, directional pulse, diversity conscience and top signals per capital for a configurable 1–120 day window.","tags":["economy","ai","capital","signals","finance"],"examples":["What is the MIND signal for the last 30 days?","Show me the directional pulse of Infrastructure capital this week."],"inputModes":["application/json","text/plain"],"outputModes":["application/json"]},{"id":"hope_signal","name":"Hope clinical-trial signal","description":"Returns live clinical-trial counts, a paginated cure-research index and platform statistics. Supports disease-keyword filtering and cursor/offset pagination.","tags":["health","clinical-trials","cures","research","medicine"],"examples":["How many active clinical trials are there for ALS?","List the latest cure-research entries."],"inputModes":["application/json","text/plain"],"outputModes":["application/json"]},{"id":"trends_signal","name":"Trends and attention-momentum signal","description":"Returns the live shape of the intelligence feed — volume, 7-day momentum and attention concentration across categories and research domains — plus the 2026 crypto token-generation-event list scored on capital distribution.","tags":["trends","momentum","attention","crypto","capital"],"examples":["What is gaining attention fastest in the AI economy this week?","Which 2026 token launches distribute capital most widely?"],"inputModes":["application/json","text/plain"],"outputModes":["application/json"]},{"id":"world_trial_search","name":"Worldwide deduplicated clinical-trial search","description":"Searches distinct real-world clinical trials across the admitted primary registries — ClinicalTrials.gov and ISRCTN — deduplicated by exact cross-registry identifier match. Filters on condition, intervention/modality, recruitment status, phase, study type, sponsor, country, enrollment, results availability and date windows. Every result carries provenance and a quotable citation.","tags":["clinical-trials","registry","evidence","search","medicine","provenance"],"examples":["Find every active human trial worldwide testing islet cell replacement for type 1 diabetes.","Which phase 3 oncology trials in the United States have completed without posting results?"],"inputModes":["application/json","text/plain"],"outputModes":["application/json"]},{"id":"world_trial_record","name":"Canonical trial record with full provenance","description":"Returns one canonical trial and every registry source record behind it, including source URLs, retrieval timestamps, payload checksums and optionally the raw registry payload.","tags":["clinical-trials","provenance","citation","evidence"],"examples":["Show me the full record and provenance for NCT07093359."],"inputModes":["application/json","text/plain"],"outputModes":["application/json"]},{"id":"trial_related_research","name":"Related research and cross-registry mentions for a trial","description":"Returns the publications a registry declares for a trial, the Europe PMC literature mentioning its registration identifiers, and the other registry identifiers that literature mentions — labelled as discovery, never as index records.","tags":["clinical-trials","literature","europe-pmc","cross-reference","evidence"],"examples":["What has been published about NCT04333823?","Are there follow-on registrations elsewhere for ISRCTN50189673?"],"inputModes":["application/json","text/plain"],"outputModes":["application/json"]},{"id":"world_trial_coverage","name":"Cross-registry coverage and duplicate-registration analysis","description":"Reports the distinct worldwide trial count for a query, cross-registry overlap, registry-exclusive trials, and the count inflation caused by summing registries instead of deduplicating them.","tags":["clinical-trials","deduplication","coverage","counting"],"examples":["How many distinct type 1 diabetes trials exist worldwide, and how many are double-registered?"],"inputModes":["application/json","text/plain"],"outputModes":["application/json"]},{"id":"world_trial_landscape","name":"Research-field landscape and longitudinal change","description":"Returns the derived structure of a research field: phase/status/study-type mix, sponsor concentration, enrollment scale, the completed-but-unreported evidence gap, 30/90/365-day momentum, per-registry field completeness and a diff against a stored earlier snapshot.","tags":["clinical-trials","analysis","landscape","momentum","evidence-gap"],"examples":["What does the type 1 diabetes trial landscape look like, and is it accelerating?","How many completed oncology trials never reported results?"],"inputModes":["application/json","text/plain"],"outputModes":["application/json"]},{"id":"world_trial_registrations","name":"Duplicate-registration resolver","description":"Resolves any registry identifier to its canonical trial, lists every registry the same real-world trial is registered in, shows the identifier evidence linking them, and names the registries it is absent from.","tags":["clinical-trials","identifiers","deduplication","resolution"],"examples":["Is NCT07093359 the same trial as ISRCTN13533177?","Which registries hold this trial, and which is it absent from?"],"inputModes":["application/json","text/plain"],"outputModes":["application/json"]},{"id":"world_trial_stats","name":"Trial corpus statistics with per-registry attribution","description":"Returns corpus size, deduplicated canonical trial count, active-trial count, curated topic ids and per-registry attribution, never summing counts across registries.","tags":["clinical-trials","statistics","attribution"],"examples":["How many trials are in the index and which registries do they come from?"],"inputModes":["application/json","text/plain"],"outputModes":["application/json"]},{"id":"registry_provenance","name":"Registry provenance, freshness and contract status","description":"Lists every upstream trial registry with licence, API type, record count, last successful sync, degraded state and the current schema-contract verdict, so coverage claims can be qualified honestly.","tags":["provenance","freshness","coverage","registries","data-quality"],"examples":["Which trial registries are covered and when did each last sync?","Is any data source currently degraded?"],"inputModes":["application/json","text/plain"],"outputModes":["application/json"]}],"interop":{"status":"discovery-only","note":"A live A2A JSON-RPC message endpoint is not yet served. Use the MCP or REST interfaces below for programmatic access today.","additionalInterfaces":[{"transport":"MCP","protocol":"streamable-http","url":"https://negativeresistance.com/api/v1/mcp"},{"transport":"REST","protocol":"openapi-3.1","url":"https://negativeresistance.com/api/v1/openapi.json"}],"discovery":{"discovery":"https://negativeresistance.com/api/v1","openapi":"https://negativeresistance.com/api/v1/openapi.json","mcp":"https://negativeresistance.com/api/v1/mcp","agentCard":"https://negativeresistance.com/.well-known/agent.json","aiPlugin":"https://negativeresistance.com/.well-known/ai-plugin.json","sdk":"https://negativeresistance.com/api/v1/sdk","status":"https://negativeresistance.com/api/v1/status","provenance":"https://negativeresistance.com/api/v1/sources","contract":"https://negativeresistance.com/api/v1/contract","documentation":"https://negativeresistance.com/embed","connect":"https://negativeresistance.com/connect"},"mcpTools":["get_mind_signal","get_hope_signal","get_trends_signal","get_batch_signals","search_world_trials","get_world_trial","get_trial_related_research","get_trial_coverage","get_trial_landscape","find_trial_registrations","get_trial_stats","get_registry_sources","list_capabilities"],"apiVersion":"1","dataHonesty":"Aggregate counts always carry per-registry attribution and the deduplication method used. A count is never presented as worldwide when a registry is degraded or was excluded."}}